NEUROPT

Non-invasive imaging of brain function and disease by pulsed near infrared light

 Coordinatore POLITECNICO DI MILANO 

 Organization address address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133

contact info
Titolo: Prof.
Nome: Rinaldo
Cognome: Cubeddu
Email: send email
Telefono: -23996073
Fax: -23996089

 Nazionalità Coordinatore Italy [IT]
 Totale costo 7˙529˙109 €
 EC contributo 5˙738˙653 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2012-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO

 Organization address address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133

contact info
Titolo: Prof.
Nome: Rinaldo
Cognome: Cubeddu
Email: send email
Telefono: -23996073
Fax: -23996089

IT (MILANO) coordinator 0.00
2    BECKER & HICKL GMBH

 Organization address address: NAHMITZER DAMM 30
city: BERLIN
postcode: 12277

contact info
Titolo: Mr.
Nome: Helmut
Cognome: Hickl
Email: send email
Telefono: +49 30 7875632
Fax: +49 30 7875734

DE (BERLIN) participant 0.00
3    CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL

 Organization address address: Via Giuseppe Mussi 1
city: MILANO
postcode: 20154

contact info
Titolo: Ms.
Nome: Carla
Cognome: Finocchiaro
Email: send email
Telefono: +39 02 31 08 33 10
Fax: +39 02 33 61 4064

IT (MILANO) participant 0.00
4    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Fräßdorf
Email: send email
Telefono: +49 3045 0576 024
Fax: +49 3045 0576 954

DE (BERLIN) participant 0.00
5    FIANIUM LTD*

 Organization address address: COMPASS POINT 20 ENSIGN WAY HAMBLE
city: SOUTHAMPTON
postcode: SO314RA

contact info
Titolo: Dr.
Nome: John
Cognome: Clowes
Email: send email
Telefono: +44 (02)380 458776
Fax: +44 (0)2380 458734

UK (SOUTHAMPTON) participant 0.00
6    FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA

 Organization address address: VIA CELORIA 11
city: MILANO
postcode: 20133

contact info
Titolo: Mr.
Nome: Alessandro
Cognome: Moneta
Email: send email
Telefono: +39 02-23942-310
Fax: +39 02 -23942-531

IT (MILANO) participant 0.00
7    INSTITUT FUR LASERTECHNOLOGIEN IN DER MEDIZIN UND MESSTECHNIK AN DER U NIVERSITAT ULM

 Organization address address: Helmholzstrasse 12
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Peter
Cognome: Spiertz
Email: send email
Telefono: +49 731 142919
Fax: +49 731 142942

DE (ULM) participant 0.00
8    INSTITUTE OF BIOCYBERNETICS AND BIOMEDICAL ENGINEERING - POLISH ACADEMY OF SCIENCES

 Organization address address: Ul. Ks Trojdena 4
city: WARSZAWA
postcode: 2109

contact info
Titolo: Ms.
Nome: Elzbieta
Cognome: Zachara
Email: send email
Telefono: +48 22 6599618
Fax: +48 22 6597030

PL (WARSZAWA) participant 0.00
9    MICRO PHOTON DEVICES S.R.L.

 Organization address address: Via Stradivari 4
city: BOLZANO
postcode: 39100

contact info
Titolo: Dr.
Nome: Roberto
Cognome: Biasi
Email: send email
Telefono: +39 0471 051 212
Fax: +39 0471 501 524

IT (BOLZANO) participant 0.00
10    PHYSIKALISCH-TECHNISCHE BUNDESANSTALT

 Organization address address: Bundesallee 100
city: BRAUNSCHWEIG
postcode: 38116

contact info
Titolo: Ms.
Nome: Maren
Cognome: Jachmann
Email: send email
Telefono: -34817285
Fax: -34817471

DE (BRAUNSCHWEIG) participant 0.00
11    UNIVERSITA DEGLI STUDI DI FIRENZE

 Organization address address: Piazza San Marco 4
city: Florence
postcode: 50121

contact info
Titolo: Prof.
Nome: Daniele
Cognome: Dominici
Email: send email
Telefono: -4572332
Fax: -4572137

IT (Florence) participant 0.00
12    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Mr.
Nome: Kent
Cognome: Lee
Email: send email
Telefono: +44 2076 7962 96
Fax: +44 2076 7965 02

UK (LONDON) participant 0.00
13    UNIVERSITY OF BATH

 Organization address address: CLAVERTON DOWN
city: BATH
postcode: BA2 7AY

contact info
Titolo: Mr.
Nome: Peter
Cognome: Hompstead
Email: send email
Telefono: +44 1225 384490
Fax: +44 1225 383276

UK (BATH) participant 0.00
14    WARSZAWSKI UNIWERSYTET MEDYCZNY

 Organization address address: UL. ZWIRKI I WIGURY 61
city: WARSZAWA
postcode: 2091

contact info
Titolo: Mr.
Nome: Michal
Cognome: Skrzek
Email: send email
Telefono: +48 22 57 20 308
Fax: +48 22 57 20 455

PL (WARSZAWA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

functional    perfusion    time    anatomical    bedside    pet    tissues    quantification    brain    technique    diseases    sensitivity    vivo    tissue    prognosis    near    data    neurological    ct    oxygenation    domain    surface    epilepsy    diffuse    monitoring    techniques    mri    positron    patients    light    resonance    infrared    diagnostic    tomography    neuropt    invasive    computed    clinical    skull    emission    continuous    blood    diagnosis    stroke    head    resolved    imaging    resolution    worked    tool    spatial    eeg    monitor    physiological    magnetic    pulsed    skin    optical   

 Obiettivo del progetto (Objective)

'The proposal aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography) provide 3D anatomical, functional or pathological information with spatial resolution in the millimetre range. However, these methods cannot be applied continuously or at the bedside. Diffuse optical imaging is expected to provide a valuable complementing tool to assess perfusion and blood oxygenation in brain tissue and their time evolution in a continuous or quasi-continuous manner. The devices will be portable and comparably inexpensive and can be applied in adults and in children. Time-domain techniques are acknowledged as offering superior information content and sensitivity compared to other optical methods, allowing for separation between contributions of surface tissues (skin and skull) and brain tissue. Time-domain imaging can also differentiate between the effects of scatter and those of absorption.The consortium plans major developments in technology and data analysis that will enhance time-domain diffuse optical imaging with respect to spatial resolution, sensitivity, robustness of quantification as well as performance of related instruments in clinical diagnosis and monitoring. The diagnostic value of time-domain diffuse optical imaging will be assessed by clinical pilot studies addressing specific neurological disorders, in comparison with established neurophysiological and neuroimaging techniques. Perspectives regarding clinical application of time-domain diffuse optical brain imaging will be estimated and a reliable basis for a potential commercialisation of this novel technique by European system manufacturers will be created.'

Introduzione (Teaser)

A European consortium worked towards the development of advanced non-invasive imaging methodologies for in vivo diagnosis, monitoring and prognosis of major neurological diseases. This integrated approach could revolutionise the diagnosis and monitoring of conditions including stroke and severe brain trauma.

Descrizione progetto (Article)

Computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) are imaging techniques that provide extensive anatomical and physiological data of outmost importance for guiding diagnosis and therapy in clinical practice. However, these methods cannot assess systemic parameters such as heart rate or blood pressure, and they cannot they be applied at the bedside. Electroencephalography (EEG) constitutes a long-standing technique that can continuously and non-invasively monitor the brain.

The EU-funded 'Non-invasive imaging of brain function and disease by pulsed near infrared light' (NEUROPT) consortium was motivated to generate a clinical tool for continuous monitoring of the haemodynamic parameters of cerebral oxygenation and perfusion. This tool should also complement MRI/CT/PET methods and at the same time be compatible with existing neuro-monitoring techniques (EEG, Doppler ultrasound).

To achieve this, partners had to improve spatial resolution of current imaging techniques, remove artefacts and enable the absolute quantification of physiological parameters. To this end, they employed time-resolved techniques that offer greater sensitivity than most optical methods and distinguish between surface tissues (e.g. skin and skull) and brain tissue.

Novel photonic devices were constructed as well as device prototypes for use in the clinical setting, including a specialised helmet for attaching the optical fibres to the head. Through software development, researchers could also analyse the time-resolved measurements on the head and calculate the oxy- and deoxyhaemoglobin concentrations. Additionally, NEUROPT researchers worked on realistic modelling and computation, especially with a view to improving light propagation in the human head.

The feasibility of this combinatorial approach was tested in separate visual and motor studies in healthy individuals. It was further successfully applied to perform measurements in patients with acute neurological conditions, photosensitive epilepsy or stroke.

Given the non-invasive nature of the NEUROPT approach and its potential to be continuously applied at the bedside, it should facilitate the diagnosis of functional brain impairment and monitor its progress. As a result, it should improve the prognosis of patients with serious neurological conditions and could also be applied for imaging the brains of infants.

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