ONCOMIRS
MicroRNAs and Cancer: From Bench to Bedside
| Coordinatore | VIB
Organization address
address: Rijvisschestraat 120 contact info |
| Nazionalità Coordinatore | Belgium [BE] |
| Sito del progetto | http://med.kuleuven.be/cme-mg/oncomirs/index.html |
| Totale costo | 4˙278˙007 € |
| EC contributo | 2˙992˙227 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-02-01 - 2013-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
VIB
Organization address
address: Rijvisschestraat 120 contact info |
BE (ZWIJNAARDE - GENT) | coordinator | 0.00 |
| 2 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 0.00 |
| 3 |
EXIQON A/S
Organization address
address: Bygstubben 9 contact info |
DK (VEDBAEK) | participant | 0.00 |
| 4 |
FUNDACIO CENTRE DE REGULACIO GENOMICA
Organization address
address: CARRER DOCTOR AIGUADER 88 contact info |
ES (BARCELONA) | participant | 0.00 |
| 5 | KOBENHAVNS UNIVERSITET | DK | participant | 0.00 |
| 6 |
UNIVERSITAET REGENSBURG
Organization address
address: UNIVERSITAETSSTRASSE 31 contact info |
DE (REGENSBURG) | participant | 0.00 |
| 7 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Although studies addressing their role in cancer pathogenesis are at an early stage, it is apparent that specific microRNAs (miRs) and molecules involved in their biogenesis contribute to tumorigenesis. The ONCOMIRS consortium proposes a natural succession of four experimental strategies. Fist, we will DISCOVER and unveil novel miRs and components of their biogenesis machinery and investigate links between these molecules and human cancers. Secondly, we will CONNECT the information obtained on deregulated miRs with known cellular pathways involved in cancer, such as the p53 tumour suppressor pathway. This will be conducted using both forward experimentations, in which targets mRNA are experimentally identified for a number of miR aetiologically related to cancer, and reverse experimentations in which mouse models and cell lines with abrogated tumour suppressor pathways or activated oncogenes are used. To establish a causal relationship between dysregualted miRs and cancer development we will MODEL the tumorigenic processes in mice lacking or overexpressing particular miRs. Finally, since the specificity and potency of some miRs suggest that they might be promising as THERAPEUTIC agents, these models will be used in conjunction with other cancer models to explore miR-based therapeutic strategies.'