INEF

Inhibiting Nef: a novel drug target for HIV-host interactions

 Coordinatore UNIVERSITEIT GENT 

 Organization address address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000

contact info
Titolo: Prof.
Nome: Bruno
Cognome: Verhasselt
Email: send email
Telefono: -93322194
Fax: -93324953

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 3˙262˙293 €
 EC contributo 2˙470˙540 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-01-01   -   2011-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT

 Organization address address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000

contact info
Titolo: Prof.
Nome: Bruno
Cognome: Verhasselt
Email: send email
Telefono: -93322194
Fax: -93324953

BE (GENT) coordinator 0.00
2    ECOSYNTH

 Organization address address: STATIONSTRAAT 123
city: OOSTENDE
postcode: 8400

contact info
Titolo: Dr.
Nome: Koen
Cognome: Van Aken
Email: send email
Telefono: +32 59 550235
Fax: +32 59 562172

BE (OOSTENDE) participant 0.00
3    HELSINGIN YLIOPISTO

 Organization address address: YLIOPISTONKATU 4
city: HELSINGIN YLIOPISTO
postcode: 14

contact info
Titolo: Prof.
Nome: Kalle
Cognome: Saksela
Email: send email
Telefono: +358- 9 191 26770
Fax: +358 9 191 26491

FI (HELSINGIN YLIOPISTO) participant 0.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Nome: Mihaja
Cognome: Auguste
Email: send email
Telefono: 01 48 07 34 18
Fax: 01 48 07 34 32

FR (PARIS) participant 0.00
5    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) participant 0.00
6    INSTITUTES DE RECHERCHES CLINIQUES DE MONTREAL

 Organization address address: "110, avenue des Pins Ouest"
city: MONTREAL
postcode: H2W 1R7

contact info
Titolo: Dr.
Nome: Louis-Gilles
Cognome: Durand
Email: send email
Telefono: -7066
Fax: -7205

CA (MONTREAL) participant 0.00
7    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Nome: Barbara
Cognome: Dobruchowski
Email: send email
Telefono: -2822
Fax: -2910

DE (MUENCHEN) participant 0.00
8    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: -50067079
Fax: -50067074

DE (ULM) participant 0.00
9    UNIVERSITE DE STRASBOURG

 Organization address address: rue Blaise Pascal 4
city: Strasbourg
postcode: 67070

contact info
Nome: Laurence
Cognome: Petin-Monteil
Email: send email
Telefono: +33 3 88 41 43 48
Fax: +33 3 68 85 42 20

FR (Strasbourg) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

viral    infected    hiv    progression    cellular    molecule    interaction    nef    small    immune    resistance    libraries    therapy    interacting    antiretroviral    drug    host    inhibitors    critical   

 Obiettivo del progetto (Objective)

'Although HIV-1 Nef was originally named "negative factor," it has been shown to be critical for efficient persistance of HIV-1 infected humans thus playing a major role in the progression to AIDS. Remarkably; until now Nef has not been evaluated as an antiretroviral drug target. It is well established that Nef promotes HIV-1 replication and facilitates viral immune evasion by interacting with various host factors. Disrupting these essential interactions may delay or even prevent disease progression. Partners in this consortium have already identified small molecule inhibitors targeting Nef function. The first objective of this project is therefore to validate the molecular events elicited by these molecules in both virus-free as well as in HIV infection in vitro assays. In a complementing approach, small compound libraries already available to the consortium will be used and adapted to screen for inhibitors of Nef induced modulation of cellular receptors, NFAT activation and the Nef SH3 binding domain, that likely contribute to the importance of Nef in HIV-1 pathogenicity. In addition, functional screenings to discover drugable cellular Nef partners using RNA interference libraries will be performed. After validation of their importance in relation to the established host proteins co-interacting in the Nef cellular pathways, a selection will be additionally targeted by the developed small molecule inhibitors. Our ultimate goal is to deliver a complementary portfolio of candidate drugs that target the most important parameters in the Nef-host interaction pathway. Critical cellular interaction partners are much more conserved than viral enzymes that are usually targeted in highly-active-antiretroviral therapy (HAART). Therefore, it is believed by the partners that the novel approach presented in this project proposal will yield compounds less likely to be subject to the occurrence of drug resistance'

Introduzione (Teaser)

Despite the development of anti-retroviral therapy, which controls the progression of HIV infections, the number of infected individuals on a global scale continues to rise. The continued evolution of viral immune pathology and the emergence of drug resistance urge the development of alternative treatment strategies.

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