SYBILLA

Systems Biology of T-cell Activation in Health and Disease

 Coordinatore ALBERT-LUDWIGS-UNIVERSITAET FREIBURG 

 Organization address address: FAHNENBERGPLATZ
city: FREIBURG
postcode: 79085

contact info
Titolo: Prof.
Nome: Wolfgang
Cognome: Schamel
Email: send email
Telefono: +49 761 203 67511
Fax: +49 761 5108 423

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.sybilla-t-cell.de/
 Totale costo 14˙636˙311 €
 EC contributo 11˙100˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2013-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

 Organization address address: FAHNENBERGPLATZ
city: FREIBURG
postcode: 79085

contact info
Titolo: Prof.
Nome: Wolfgang
Cognome: Schamel
Email: send email
Telefono: +49 761 203 67511
Fax: +49 761 5108 423

DE (FREIBURG) coordinator 0.00
2    ACIES Consulting Group SAS

 Organization address city: LYON
postcode: 69002

contact info
Titolo: Mr.
Nome: Patrick
Cognome: Duvarry
Email: send email
Telefono: +33 4 78 92 40 00
Fax: +33 4 78 92 40 01

FR (LYON) participant 0.00
3    ACIES SAS

 Organization address address: RUE DE LA REPUBLIQUE 69
city: LYON
postcode: 69002

contact info
Titolo: Mr.
Nome: Patrick
Cognome: Duvarry
Email: send email
Telefono: -78923971
Fax: -78923972

FR (LYON) participant 0.00
4    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Prof.
Nome: Balbino
Cognome: Alarcon
Email: send email
Telefono: +34 915855000
Fax: +34 914113077

ES (MADRID) participant 0.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Béatrice
Cognome: Saint-Cricq
Email: send email
Telefono: +33 4 91 16 40 08
Fax: +33 4 91 77 93 40

FR (PARIS) participant 0.00
6    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

 Organization address address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036

contact info
Titolo: Ms.
Nome: Pastora
Cognome: Martinez Samper
Email: send email
Telefono: +34 932275707
Fax: +34 932279205

ES (BARCELONA) participant 0.00
7    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Ina
Cognome: Krischek
Email: send email
Telefono: +49 6221 42 2700
Fax: +49 6221 42 2708

DE (HEIDELBERG) participant 0.00
8    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH

 Organization address address: Raemistrasse 101
city: ZUERICH
postcode: 8092

contact info
Titolo: Dr.
Nome: Ruedi
Cognome: Aebersold
Email: send email
Telefono: +41 44 6333170
Fax: +41 44 6331051

CH (ZUERICH) participant 0.00
9    EXBIO PRAHA AS

 Organization address address: Nad Safinou II 341
city: VESTEC
postcode: 25242

contact info
Titolo: Dr.
Nome: Jolana
Cognome: Vosáhlová
Email: send email
Telefono: 420261000000
Fax: 420261000000

CZ (VESTEC) participant 0.00
10    FONDAZIONE HUMANITAS PER LA RICERCA

 Organization address address: Via Manzoni 56
city: ROZZANO
postcode: 20089

contact info
Titolo: Dr.
Nome: Danilo
Cognome: Petroni
Email: send email
Telefono: +39 02 82242435
Fax: +39 02 82245191

IT (ROZZANO) participant 0.00
11    Immune Disease Institute

 Organization address address: HUNTINGTON AVENUE 800
city: BOSTON
postcode: MA 02115

contact info
Titolo: Mr.
Nome: Stephen
Cognome: Carriuolo
Email: send email
Telefono: +1 617 278 3426
Fax: +1 617 278 3492

US (BOSTON) participant 0.00
12    INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY

 Organization address address: PADRICIANO 99
city: TRIESTE
postcode: 34149

contact info
Titolo: Ms.
Nome: H.S.
Cognome: Narayanan
Email: send email
Telefono: +91 11 26742357
Fax: +91 1 26742316

IT (TRIESTE) participant 0.00
13    Joslin Diabetes Center

 Organization address address: One Joslin place
city: "BOSTON, MASSACHUSETTS"

contact info
Titolo: Ms.
Nome: Natalie
Cognome: Liang
Email: send email
Telefono: +1 617 732 2543
Fax: +1 617 732 2542

US ("BOSTON, MASSACHUSETTS") participant 0.00
14    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Miriam
Cognome: Vitt
Email: send email
Telefono: +49 761 5108 420
Fax: +49 761 5108 423

DE (MUENCHEN) participant 0.00
15    MEDICEL OY

 Organization address address: HAARTMANINKATU 8
city: HELSINKI
postcode: 290

contact info
Titolo: Prof.
Nome: Risto
Cognome: Renkonen
Email: send email
Telefono: -19124762
Fax: -19124806

FI (HELSINKI) participant 0.00
16    MEDIZINISCHE UNIVERSITAET INNSBRUCK

 Organization address address: Christoph-Probst Platz 1
city: INNSBRUCK
postcode: 6020

contact info
Titolo: Prof.
Nome: Gottfried
Cognome: Baier
Email: send email
Telefono: +43 512 9003 70514
Fax: +43 512 9003 73510

AT (INNSBRUCK) participant 0.00
17    NOVAMEN SAS

 Organization address city: LYON
postcode: 69002

contact info
Titolo: Mr.
Nome: Patrick
Cognome: Duvarry
Email: send email
Telefono: +33 4 78 92 40 00
Fax: +33 4 78 92 40 01

FR (LYON) participant 0.00
18    OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG

 Organization address address: UNIVERSITAETSPLATZ 2
city: MAGDEBURG
postcode: 39106

contact info
Titolo: Ms.
Nome: Ingrid
Cognome: Anders
Email: send email
Telefono: +49 391 6718770
Fax: +49 391 6718069

DE (MAGDEBURG) participant 0.00
19    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Mr.
Nome: Martin
Cognome: Wilkins
Email: send email
Telefono: +44 1865 275530
Fax: +44 1865 275515

UK (OXFORD) participant 0.00
20    TTY-SAATIO

 Organization address address: Korkeakoulunkatu 10
city: TAMPERE
postcode: 33720

contact info
Titolo: Ms.
Nome: Merja
Cognome: Fagerström
Email: send email
Telefono: 358408000000
Fax: 358331000000

FI (TAMPERE) participant 0.00
21    TURUN YLIOPISTO

 Organization address address: YLIOPISTONMAKI
city: TURUN YLIOPISTO
postcode: 20014

contact info
Titolo: Dr.
Nome: Eliisa
Cognome: Särkilahti
Email: send email
Telefono: +358 2 3336155
Fax: +358 2 3336446

FI (TURUN YLIOPISTO) participant 0.00
22    UNIVERSITAETSSPITAL BASEL

 Organization address address: HEBELSTRASSE 32
city: BASEL
postcode: 4031

contact info
Titolo: Prof.
Nome: Ed
Cognome: Palmer
Email: send email
Telefono: +41 612653120
Fax: +41 612653420

CH (BASEL) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

signalling    autoimmune    quantitative    physiological    auto    cells    diseases    antigens    data    model    mouse    multiple    cell    sybilla    disorders    network    activation   

 Obiettivo del progetto (Objective)

'T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. To a large extent this is attributed to the lack of systems-level insights, which would provide concepts of how to modulate T-cell activation. The SYBILLA project groups 14 partners from 9 different EU countries, including 3 SMEs. Through a multidisciplinary effort it aims to understand at the systems’ level, how T-cells discriminate foreign from auto-antigens. Towards this goal, a transgenic mouse system will be used as a tractable physiological model. Data will be validated in human T-cells and a humanised mouse model for multiple sclerosis. SYBILLA will develop technological and mathematical tools to generate and integrate high-density quantitative data describing T-cell activation. Proteomics, transcriptomics, metabolomics, imaging and multiplexed biochemical techniques will be applied to obtain holistic maps of T-cell signalling networks and to achieve a quantitative understanding of the network and its regulation in response to different inputs. Building upon our existing network model, constant iterations will be used to develop more robust dynamic models to describe the network’s response to perturbations. This will culminate in the generation of a Virtual T-Cell, allowing computer simulation to refine the predictability of physiological and pathophysiological reactions. SYBILLA’s impact on EU biopharmaceutical competitiveness will be enormous through identification of new pharmacologic targets, optimised prediction of immunomodulatory drug efficacy, discovery of new concerted biomarkers and improvement of personalised medication for treating autoimmune diseases.'

Introduzione (Teaser)

Autoimmune disorders impose a heavy socioeconomic burden on industrialised societies. Outlining the mechanisms responsible for such abnormal immune responses may give rise to new drugs and improve clinical outcome.

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