MITIN

INTEGRATION OF THE SYSTEM MODELS OF INSULIN SIGNALLING AND OF MITOCHONDRIAL FUNCTION AND ITS APPLICATION IN THE STUDY OF COMPLEX DISEASES

 Coordinatore FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) 

 Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
city: BARCELONA
postcode: 8028

contact info
Titolo: Ms.
Nome: Adriana
Cognome: Grosu
Email: send email
Telefono: + 34 93 402 04 50
Fax: +34 93 403 71 14

 Nazionalità Coordinatore Spain [ES]
 Totale costo 3˙846˙079 €
 EC contributo 2˙956˙490 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-11-01   -   2011-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)

 Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
city: BARCELONA
postcode: 8028

contact info
Titolo: Ms.
Nome: Adriana
Cognome: Grosu
Email: send email
Telefono: + 34 93 402 04 50
Fax: +34 93 403 71 14

ES (BARCELONA) coordinator 0.00
2    BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION

 Organization address address: Calle Jordi Girona 31
city: BARCELONA
postcode: 8034

contact info
Titolo: Ms.
Nome: Mercè
Cognome: Calvet
Email: send email
Telefono: + 34 93 413 77 17
Fax: +34 93 413 77 21

ES (BARCELONA) participant 0.00
3    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Ms.
Nome: Bettina
Cognome: Crispin
Email: send email
Telefono: +49 6221 42 2700
Fax: +49 6221 42 2708

DE (HEIDELBERG) participant 0.00
4    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Katri
Cognome: Kokkila
Email: send email
Telefono: +358 20 722 33 03
Fax: + 358 20 722 33 65

FI (ESPOO) participant 0.00
5    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Dawn
Cognome: Edwards
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) participant 0.00
6    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Dr.
Nome: Jane
Cognome: Cloke
Email: send email
Telefono: +44 151 794 8726
Fax: +44 151 794 8728

UK (LIVERPOOL) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

mechanisms    insulin    functional    interactions    disorders    diabetes    framework    obesity    mitochondrial    signalling    integrate    tools    resistance    diseases    associations    computer    networks    computational    data    biology    mitochondria   

 Obiettivo del progetto (Objective)

'A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal is to identify novel mitochondrial-dependent mechanisms responsible for the development of insulin resistance. This will be done by the use of technologies of Systems Biology and the generation of computer-based tools that will permit the study of complex biological systems that integrate different regulatory networks. For the global visualization and interpretation of the “insulin signalling/mitochondria” complex system we plan to develop a computational framework that will store and integrate all possible data for each of the subsystems, both currently available data and data generated within the project by transcriptomics and lipidomics analysis. This will allow the prediction of functional associations and interactions between both processes, which will be tested under specific hypothesis-driven studies in mammalian cells, mice and Drosophila. By using a Systems Biology approach and investigating how different perturbations modulate cell transcriptomes, and lipidomes, we aim to identify integrated homeostatic responses involving the insulin signalling network and the mitochondria networks. Validation of some of the strongest associations detected by virtue of the integrated systems biology of insulin signalling/mitochondria will generate high value targets of use in therapy against Complex Diseases such as diabetes, obesity, or pathophysiological traits of the Metabolic Syndrome. Besides, computer-based tools generated in the project will be applicable to the analysis of the mechanisms that trigger other Complex Diseases.'

Introduzione (Teaser)

A European consortium developed a computational framework enabling them to predict functional associations and interactions between insulin signalling and mitochondrial processes. Results led to the identification of novel genes of potential clinical relevance.

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