EVINCI-STUDY

Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease

 Coordinatore CONSIGLIO NAZIONALE DELLE RICERCHE 

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Mr.
Nome: Marco
Cognome: Borbotti
Email: send email
Telefono: +39 050 3153720
Fax: +39 050 3153738

 Nazionalità Coordinatore Italy [IT]
 Sito del progetto http://www.escardio.org/communities/Working-Groups/nuclear-cardiology/Pages/EVINCIStudy.aspx
 Totale costo 3˙432˙418 €
 EC contributo 2˙695˙402 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2012-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Mr.
Nome: Marco
Cognome: Borbotti
Email: send email
Telefono: +39 050 3153720
Fax: +39 050 3153738

IT (ROMA) coordinator 632˙071.00
2    TURUN YLIOPISTO

 Organization address address: YLIOPISTONMAKI
city: TURUN YLIOPISTO
postcode: 20014

contact info
Titolo: Dr.
Nome: Eliisa
Cognome: Särkilahti
Email: send email
Telefono: 35823336155
Fax: 35823336446

FI (TURUN YLIOPISTO) participant 450˙023.10
3    Nome Ente NON disponibile

 Organization address address: via Trieste 41
city: Pisa
postcode: 56126

contact info
Titolo: Dr.
Nome: Luciano
Cognome: Ciucci
Email: send email
Telefono: +39 0503153727
Fax: +39 0503153701

IT (Pisa) participant 233˙031.84
4    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Ms.
Nome: Sietske
Cognome: Hoekstra-Byvank
Email: send email
Telefono: +31 71 5264965
Fax: +31 71 5266941

NL (LEIDEN) participant 199˙115.02
5    QUEEN MARY UNIVERSITY OF LONDON

 Organization address address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
Titolo: Ms.
Nome: Tanya
Cognome: Szendeffy
Email: send email
Telefono: +44 20 7882 7266
Fax: +44 20 7882 7266

UK (LONDON) participant 120˙247.88
6    UNIVERSITA DEGLI STUDI DI GENOVA

 Organization address address: VIA BALBI 5
city: GENOVA
postcode: 16126

contact info
Titolo: Ms.
Nome: Maria Angela
Cognome: Ferrera
Email: send email
Telefono: +39 010 3537928
Fax: +39 010 3537989

IT (GENOVA) participant 112˙821.36
7    SERVICIO MADRILENO DE SALUD

 Organization address address: PLAZA CARLOS TRIAS BERTRAN 7
city: MADRID
postcode: 28020

contact info
Titolo: Mr.
Nome: José Francisco
Cognome: Soto Bonel
Email: send email
Telefono: +34 91 3303793
Fax: +34 91 3303515

ES (MADRID) participant 107˙893.24
8    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

 Organization address address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675

contact info
Titolo: Ms.
Nome: Renate
Cognome: Rädlein
Email: send email
Telefono: +49 89 4140 2842
Fax: +49 89 4140 4926

DE (MUENCHEN) participant 98˙962.99
9    ROYAL BROMPTON AND HAREFIELD NATIONAL HEALTH SERVICE TRUST

 Organization address address: SYDNEY STREET
city: LONDON
postcode: SW3 6NP

contact info
Titolo: Mr.
Nome: George
Cognome: Karagiannis
Email: send email
Telefono: +44 0 207 351 8736
Fax: +44 0 207 351 8578

UK (LONDON) participant 95˙272.12
10    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Philipp
Cognome: Kaufmann
Email: send email
Telefono: +41 44 255 4196
Fax: +41 44 255 4414

CH (ZURICH) participant 92˙706.00
11    INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO

 Organization address address: ul. Alpejska 42
city: WARSZAWA
postcode: 4628

contact info
Titolo: Ms.
Nome: Liliana
Cognome: Chojnacka
Email: send email
Telefono: +48 22 343 4607
Fax: +48 22 343 4523

PL (WARSZAWA) participant 89˙980.81
12    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Mr.
Nome: Christophe
Cognome: Misse
Email: send email
Telefono: +331 44 84 17 70
Fax: +331 44 84 17 88

FR (PARIS) participant 84˙513.16
13    CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL

 Organization address address: Via Giuseppe Mussi 1
city: MILANO
postcode: 20154

contact info
Titolo: Ms.
Nome: Carla
Cognome: Finocchiaro
Email: send email
Telefono: +39 02 3108331
Fax: +39 02 3361 4064

IT (MILANO) participant 79˙661.10
14    INSTITUT CATALA DE LA SALUT

 Organization address address: GRAN VIA DE LES CORTS CATALANES 587
city: BARCELONA
postcode: 8007

contact info
Titolo: Dr.
Nome: Santiago
Cognome: Aguade
Email: send email
Telefono: +34 93 2746122
Fax: +34 93 2746225

ES (BARCELONA) participant 56˙265.54
15    INFORSENSE LIMITED

 Organization address address: HAMMERSMITH ROAD COLET COURT 100
city: London
postcode: W6 7JP

contact info
Titolo: Mr.
Nome: Martin
Cognome: Naughalty
Email: send email
Telefono: +44 (0) 20 8237 8518
Fax: +44 (0) 20 8237 8441

UK (London) participant 46˙740.90
16    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.

 Organization address address: Corso Umberto I 40
city: NAPOLI
postcode: 80138

contact info
Titolo: Ms.
Nome: Renata
Cognome: D'amico
Email: send email
Telefono: +39 081 7464374
Fax: +39 081 74623894

IT (NAPOLI) participant 45˙032.36
17    ALB FILS KLINIKEN GMBH

 Organization address address: EICHERTSTRASSE 3
city: GOPPINGEN
postcode: 73035

contact info
Titolo: Prof.
Nome: Jörg
Cognome: Martin
Email: send email
Telefono: +49 7161 642404
Fax: +49 7161 64 1829

DE (GOPPINGEN) participant 40˙000.00
18    AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI

 Organization address address: via delle Oblate 1
city: FIRENZE
postcode: 50139

contact info
Titolo: Ms.
Nome: Mariagrazia
Cognome: Catania
Email: send email
Telefono: +39 055 4598 944
Fax: +39 055 4598 944

IT (FIRENZE) participant 40˙000.00
19    Azienda U.S.L. N. 12 di Viareggio

 Organization address address: Via Aurelia 335
city: Lucca
postcode: 55041

contact info
Titolo: Dr.
Nome: Claudio
Cognome: Rapalini
Email: send email
Telefono: +39 0584 605 9669
Fax: +39 0584 67646

IT (Lucca) participant 30˙000.00
20    SOCIETE EUROPEENNE DE CARDIOLOGIE

 Organization address address: ROUTE DES COLLES 2035
city: BIOT SOPHIA ANTIPOLIS
postcode: 6903

contact info
Titolo: Ms.
Nome: Francoise
Cognome: Heraud
Email: send email
Telefono: +33 492 94 76 06
Fax: +33 492 94 86 20

FR (BIOT SOPHIA ANTIPOLIS) participant 28˙180.00
21    FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU

 Organization address address: CALLE SANT ANTONI M CLARET 167
city: BARCELONA
postcode: 8025

contact info
Titolo: Ms.
Nome: Hilda
Cognome: Herrero
Email: send email
Telefono: +34 932919046
Fax: +34 934552331

ES (BARCELONA) participant 12˙883.59
22    TECHNISCHE UNIVERSITAET MUENCHEN

 Organization address address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333

contact info
Titolo: Ms.
Nome: Inge
Cognome: Linder
Email: send email
Telefono: +49 89 4140 4529
Fax: +49 89 4140 4926

DE (MUENCHEN) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cooperation    physicians    outcome    detection    intracoronary    tested    imaging    heart    individual    had    resonance    clinical    computed    tomography    esc    mortality    cardiovascular    risk    diagnostic    stress    prevention    single    invasive    diagnosis    patients    ihd    cohort    emission    accuracy    disease    techniques    probability    magnetic    coronary    suspected    angiography    characterization    evinci    addition    biohumoral    ultrasound    cardiac    patient    ctca    wall    tests    functional    combined    anatomo    technique    performed   

 Obiettivo del progetto (Objective)

'The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.'

Introduzione (Teaser)

A recent study evaluated an integrated non-invasive cardiac imaging technique for the detection of ischaemic heart disease (IHD).

Descrizione progetto (Article)

Cardiovascular disease is a major cause of death across Europe. Although cardiovascular mortality rates, adjusted for age, are generally declining, the prevalence of IHD is increasing due to the emergence of new risk factors.

In order to further reduce cardiovascular mortality and morbidity, better prevention and management of IHD is needed. A common technique for the diagnosis of IHD is invasive coronary angiography, but its current diagnostic yeld is suboptimal mainly due to underutilization of non-invasive tests prior to the invasive study.

The EU-funded EVINCI-STUDY project investigated the diagnostic accuracy of combining non-invasive anatomical information from computed tomography coronary angiography (CTCA) with functional information from stress imaging. The aim is to achieve earlier non-invasive detection and characterisation and thus better management of IHD. Project partners performed the investigations in a cohort of 697 patients with suspected IHD, and low-intemediate probability of disease, selected from 14 clinical centres across Europe.

Comparison of several imaging techniques for their diagnostic accuracy to detect obstructive coronary disease and predict revascularization revealed that CTCA had better diagnostic performance than stress imaging. Perfusion based imaging techniques (Single-photon emission computed tomography (SPECT) and positron emission tomography (PET)) had greater sensitivity, while wall motion based techniques (echocardiogram (ECHO) and cardiac magnetic resonance (CMR)) had greater specificity. In addition, integration of CTCA with functional imaging increased diagnostic accuracy of functional imaging alone.

Project members implemented a multimodal electronic tool to enable the organisation and visualization of all available information (clinical, biological and cardiac imaging) for a single patient. This ensured easy presentation of the integrated information at multiple levels of complexity to specialists and referring physicians, including medical practitioners.

In years to come, there will hopefully be a reduction in the use of invasive procedures, inappropriate revascularisation and health costs due to poor management. In addition, early detection could promote prevention and early treatment programmes.

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