ANGIOSCAFF
Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering
| Coordinatore | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
| Nazionalità Coordinatore | Switzerland [CH] |
| Sito del progetto | http://www.angioscaff.eu |
| Totale costo | 15˙468˙430 € |
| EC contributo | 11˙631˙240 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2007-LARGE-1 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-12-01 - 2012-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | coordinator | 0.00 |
| 2 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 0.00 |
| 3 |
BAXTER INNOVATIONS GMBH
Organization address
address: INDUSTRIESTRASSE 67 contact info |
AT (WIEN) | participant | 0.00 |
| 4 |
BAYER INNOVATION GMBH
Organization address
address: MEROWINGER PLATZ 1 contact info |
DE (DUSSELDORF) | participant | 0.00 |
| 5 |
BIO-HYOS AB
Organization address
address: VIRDINGS ALLE 32 B contact info |
SE (UPPSALA) | participant | 0.00 |
| 6 |
BIORIGEN S.R.L.
Organization address
address: VIA DE MARINI 1 7TH FLOOR contact info |
IT (GENOVA) | participant | 0.00 |
| 7 |
DANDO WEISS & COLUCCI LIMITED
Organization address
address: LOWER BRISTOL ROAD MINERVA HOUSE contact info |
UK (BATH) | participant | 0.00 |
| 8 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | participant | 0.00 |
| 9 |
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Organization address
address: Via Olgettina 60 contact info |
IT (MILANO) | participant | 0.00 |
| 10 |
FONDAZIONE MULTIMEDICA ONLUS
Organization address
address: VIA FANTOLI 16/15 contact info |
IT (MILANO) | participant | 0.00 |
| 11 |
FONDAZIONE PARCO BIOMEDICO SAN RAFFAELE
Organization address
address: VIA CASTEL ROMANO 100 contact info |
IT (ROMA) | participant | 0.00 |
| 12 |
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 contact info |
ES (BARCELONA) | participant | 0.00 |
| 13 |
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Organization address
address: "Via Adamello, 16" contact info |
IT (MILAN) | participant | 0.00 |
| 14 |
INTERCYTEX LTD
Organization address
address: CREWE ROAD INNOVATION HOUSE contact info |
UK (MANCHESTER) | participant | 0.00 |
| 15 |
IRCCS AZIENDA OSPEDALIERA UNIVERSITARIA SAN MARTINO-IST-ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
Organization address
address: LARGO ROSANNA BENZI 10 contact info |
IT (GENOVA) | participant | 0.00 |
| 16 |
ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
Organization address
address: Largo Rosanna Benzi 10 contact info |
IT (GENOVA) | participant | 0.00 |
| 17 |
JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN
Organization address
address: GRUNEBURGPLATZ 1 contact info |
DE (FRANKFURT AM MAIN) | participant | 0.00 |
| 18 |
KUROS BIOSURGERY AG
Organization address
address: TECHNOPARKSTRASSE 1 contact info |
CH (ZURICH) | participant | 0.00 |
| 19 |
LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV
Organization address
address: HOHE STRASSE 6 contact info |
DE (DRESDEN) | participant | 0.00 |
| 20 |
LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Organization address
address: NUSSDORFER STRASSE 64/6 contact info |
AT (WIEN) | participant | 0.00 |
| 21 |
MILTENYI BIOTEC GMBH
Organization address
address: FRIEDRICH EBERT STRASSE 68 contact info |
DE (BERGISCH GLADBACH) | participant | 0.00 |
| 22 |
NEWRON SWEDEN AB
Organization address
address: FISKARTORPSVAGEN 15 A D contact info |
SE (STOCKHOLM) | participant | 0.00 |
| 23 |
SMITH & NEPHEW UK LIMITED
Organization address
address: ADAM STREET 15 contact info |
UK (LONDON) | participant | 0.00 |
| 24 |
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Organization address
address: TECHNION CITY - SENATE BUILDING contact info |
IL (HAIFA) | participant | 0.00 |
| 25 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 0.00 |
| 26 |
THE UNIVERSITY OF NOTTINGHAM
Organization address
address: University Park contact info |
UK (NOTTINGHAM) | participant | 0.00 |
| 27 |
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Organization address
address: Piazzale Aldo Moro 5 contact info |
IT (ROMA) | participant | 0.00 |
| 28 |
UNIVERSITAET ZU KOELN
Organization address
address: ALBERTUS MAGNUS PLATZ contact info |
DE (KOELN) | participant | 0.00 |
| 29 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 0.00 |
| 30 |
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Organization address
address: Martinistrasse 52 contact info |
DE (HAMBURG) | participant | 0.00 |
| 31 |
UNIVERSITAETSSPITAL BASEL
Organization address
address: HEBELSTRASSE 32 contact info |
CH (BASEL) | participant | 0.00 |
| 32 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | participant | 0.00 |
| 33 |
UPPSALA UNIVERSITET
Organization address
address: SANKT OLOFSGATAN 10 B contact info |
SE (UPPSALA) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and remodel the ECM to create pores into which angiogenic endothelial cells migrate. This observation, that physiological angiogenesis proceeds in response to solid-phase cues motivates our approach, namely creating bioactive resorbable materials as scaffolds that contain bound molecular signals to induce physiological angiogenesis in situations of tissue repair and regeneration. In some of our scaffold materials, porosity is inherent by virtue of fabrication, and in others porosity is created by cell-associated proteolysis as it is in physiological angiogenesis. All materials will be designed so as to be injectable or implantable into the human body. In some work, the final injectable/implantable material will comprise only materials and bioactive biomolecular signals, and in other cases it will also comprise cells. Thus, the concept of ANGIOSCAFF is to create materials that are bioresponsive (to environmental signals including pH and redox potential, and to cellular signals such as proteases), that are bioactive (by virtue of bound peptide or recombinant protein adhesion ligands and bound and releasable growth factors), and that are capable of carrying cellular therapeutics. To realize ANGIOSCAFF, we have assembled a team comprising both industrial and academic expert groups in biomaterials design and development, experts in the science and application of angiogenesis, in imaging in animal models, and in applications demanding biomaterials-based, angiogenesis-demanding tissue engineering therapies, including repair of bone, skin, cardiac muscle, skeletal muscle and nerve.'