INTEGER

Integrated approaches to study gene regulation during cellular differentiation

 Coordinatore BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

 Organization address address: Al. Fleming Street 34
city: VARI-ATHENS
postcode: 16672

contact info
Titolo: Dr.
Nome: John
Cognome: Strouboulis
Email: send email
Telefono: -8970232
Fax: -8979888

 Nazionalità Coordinatore Greece [EL]
 Totale costo 2˙300˙000 €
 EC contributo 2˙300˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-1-1-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2012-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

 Organization address address: Al. Fleming Street 34
city: VARI-ATHENS
postcode: 16672

contact info
Titolo: Dr.
Nome: John
Cognome: Strouboulis
Email: send email
Telefono: -8970232
Fax: -8979888

EL (VARI-ATHENS) coordinator 712˙929.94
2    FONDAZIONE TELETHON

 Organization address address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
Titolo: Dr.
Nome: Valerio
Cognome: Orlando
Email: send email
Telefono: -501703229
Fax: -501703828

IT (ROMA) participant 381˙339.20
3    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Ana
Cognome: Pombo
Email: send email
Telefono: -83838208
Fax: -83838282

UK (SWINDON) participant 214˙480.19
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Ms.
Nome: Philippa
Cognome: Kraftl
Email: send email
Telefono: -289470
Fax: -289337

UK (OXFORD) participant 212˙830.19
5    Source Bioscience plc

 Organization address address: "ORCHARD PLACE, BUSINESS PARK 1"
city: NOTTINGHAM
postcode: NG8 6PX

contact info
Titolo: Mr.
Nome: Robert
Cognome: Bakewell
Email: send email
Telefono: 44-115-9739012
Fax: 44-115-9739011

UK (NOTTINGHAM) participant 207˙880.19
6    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Axel
Cognome: Imhof
Email: send email
Telefono: -218075460
Fax: +49-89-218075 440

DE (MUENCHEN) participant 205˙009.20
7    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Titolo: Mr.
Nome: Don
Cognome: Van Velzen
Email: send email
Telefono: -2121799
Fax: -212864

NL (AMSTERDAM) participant 204˙047.80
8    "BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"

 Organization address address: Soranou Efesiou 4
city: ATHENS
postcode: 11527

contact info
Titolo: Prof.
Nome: Dimitris
Cognome: Thanos
Email: send email
Telefono: -6597424
Fax: -6597779

EL (ATHENS) participant 161˙483.30

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

mature    employed    stem    domains    chromatin    nucleus    transcription    differentiation    context    global    training    mechanisms    cells    cell    interactions    networks    itn    gene    identity    cellular    memory    dna    nuclear    epigenetic   

 Obiettivo del progetto (Objective)

'Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, all of which contribute to gene regulation mechanisms. The main aim of this ITN is to get a comprehensive view on the mechanisms controling gene expression during cell differentiation by integrating studies on multiple regulatory levels from DNA binding transcription factors through to nuclear organization. We will take a multi-faceted approach addressing the functions of: (i) transcription factors and their co-factors (ii) chromatin domains and histone variants, (iii) epigenetic mechanisms of cellular memory and identity, (iv) global gene interactions in nuclear space and (iv) nuclear territories of gene activity. Genomics approaches will be employed to describe global changes in gene target networks and gene interactions in the nucleus during ES cell differentiation into the hepatic, neuronal and hematopoietic lineages. Proteomics will be employed for the characterization of transcription factor and epigenetic modifying complexes and of the in vivo protein composition of specialized chromatin domains. The research activities of this ITN are organized in the context of a multidisciplinary Training Program, which provides unique opportunities for the training of early stage researchers to address fundamental biological questions with far reaching implications in biotechnology and human health.'

Introduzione (Teaser)

Development of a stem cell to its mature counterpart with a specific identity is controlled by complex transcription networks. An EU project has uncovered new mechanisms that direct the cell differentiation journey.

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