EUROV1SION

Imaging function and dysfunction of neuronal circuits in the visual cortex

 Coordinatore KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Titolo: Mr.
Nome: Rikesh
Cognome: Balgobind
Email: send email
Telefono: +31 20 5666903
Fax: +31 20 5666121

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.eurov1sion.eu
 Totale costo 3˙479˙957 €
 EC contributo 2˙598˙906 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-12-01   -   2013-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Titolo: Mr.
Nome: Rikesh
Cognome: Balgobind
Email: send email
Telefono: +31 20 5666903
Fax: +31 20 5666121

NL (AMSTERDAM) coordinator 0.00
2    BITPLANE AG

 Organization address address: BADENERSTRASSE 682
city: ZUERICH
postcode: 8048

contact info
Titolo: Mr.
Nome: Bernard
Cognome: Quinn
Email: send email
Telefono: +41 44 430 11 00
Fax: +41 44 430 11 01

CH (ZUERICH) participant 0.00
3    CARDIFF UNIVERSITY

 Organization address address: Newport Road 30-36
city: CARDIFF
postcode: CF24 ODE

contact info
Titolo: Mr.
Nome: Nick
Cognome: Bodycombe
Email: send email
Telefono: +44 29 20870171
Fax: +44 29 20874189

UK (CARDIFF) participant 0.00
4    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Annette
Cognome: Starke
Email: send email
Telefono: +49 89 8578 3776
Fax: +49 89 8578 3635

DE (MUENCHEN) participant 0.00
5    MINDWEAVERS PLC

 Organization address address: MILL STREET
city: OXFORD
postcode: OX2 0JX

contact info
Titolo: Mr.
Nome: Bruce
Cognome: Robinson
Email: send email
Telefono: +44 1865 811123
Fax: +44 1865 793165

UK (OXFORD) participant 0.00
6    THE UNIVERSITY OF NOTTINGHAM

 Organization address address: University Park
city: NOTTINGHAM
postcode: NG7 2RD

contact info
Titolo: Mr.
Nome: Paul
Cognome: Cartledge
Email: send email
Telefono: +44 115 951 5679
Fax: +44 115 951 3633

UK (NOTTINGHAM) participant 0.00
7    UNIVERSITA DEGLI STUDI DI FIRENZE

 Organization address address: Piazza San Marco 4
city: Florence
postcode: 50121

contact info
Titolo: Prof.
Nome: Cristina
Cognome: Stefanile
Email: send email
Telefono: +39 055 6237828
Fax: +39 055 623607

IT (Florence) participant 0.00
8    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Mr.
Nome: Kent
Cognome: Lee
Email: send email
Telefono: +44 20 7679 6296
Fax: +44 20 7679 6502

UK (LONDON) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

plasticity    adult    neuronal    disorders    cns    ca    molecular    recovery    directly    brain    visual    amblyopia    cortex    treatment   

 Obiettivo del progetto (Objective)

'The research program aims to understand the dynamics of the structural and functional organization of the visual cortex and the implications for amblyopia ('lazy eye', the most prevalent visual disorder among young people). We will study these fundamental issues from the molecular level all the way to the network level. To achieve this, members of the consortium have - for the first time - established chronic in vivo two photon imaging of Ca2 responses in the visual cortex by making use of a novel genetically encoded Ca2 sensor. Using this powerful new methodology we will study how experience changes firing properties of individual neurons of known identity and how this correlates with changes in inhibitory and excitatory synaptic structures. Using the same approach we will study the neuronal substrate of amblyopia and how it alters coding of visual information. Next we will study how binocular experience leads to recovery from amblyopia and how perceptual learning can improve this in animal models and human subjects. This knowledge will be directly translated into new treatments of amblyopia by one of the participating SMEs. Last we will study the molecular and cellular mechanisms that restrict plasticity in the adult visual system with the aim to achieve increased experience dependent plasticity in the adult brain. This knowledge can be used for the treatment of disorders of the CNS from which recovery is limited due to restricted plasticity. Apart from amblyopia, these include brain tumors, stroke, degenerative diseases and trauma. Together this program will provide comprehensive insight into the neuronal interactions underpinning function and dysfunction of the visual cortex and will contribute directly to improved treatment of amblyopia and development of plasticity based approaches for curing a large array of disorders of the CNS.'

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