EUROV1SION

Imaging function and dysfunction of neuronal circuits in the visual cortex

Coordinatore	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW    more  Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV contact info Titolo: Mr. Nome: Rikesh Cognome: Balgobind Email: send email Telefono: +31 20 5666903 Fax: +31 20 5666121
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.eurov1sion.eu
Totale costo	3˙479˙957 €
EC contributo	2˙598˙906 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-12-01   -   2013-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW  Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV contact info Titolo: Mr. Nome: Rikesh Cognome: Balgobind Email: send email Telefono: +31 20 5666903 Fax: +31 20 5666121	NL (AMSTERDAM)	coordinator	0.00
2	BITPLANE AG  Organization address address: BADENERSTRASSE 682 city: ZUERICH postcode: 8048 contact info Titolo: Mr. Nome: Bernard Cognome: Quinn Email: send email Telefono: +41 44 430 11 00 Fax: +41 44 430 11 01	CH (ZUERICH)	participant	0.00
3	CARDIFF UNIVERSITY  Organization address address: Newport Road 30-36 city: CARDIFF postcode: CF24 ODE contact info Titolo: Mr. Nome: Nick Cognome: Bodycombe Email: send email Telefono: +44 29 20870171 Fax: +44 29 20874189	UK (CARDIFF)	participant	0.00
4	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Annette Cognome: Starke Email: send email Telefono: +49 89 8578 3776 Fax: +49 89 8578 3635	DE (MUENCHEN)	participant	0.00
5	MINDWEAVERS PLC  Organization address address: MILL STREET city: OXFORD postcode: OX2 0JX contact info Titolo: Mr. Nome: Bruce Cognome: Robinson Email: send email Telefono: +44 1865 811123 Fax: +44 1865 793165	UK (OXFORD)	participant	0.00
6	THE UNIVERSITY OF NOTTINGHAM  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Mr. Nome: Paul Cognome: Cartledge Email: send email Telefono: +44 115 951 5679 Fax: +44 115 951 3633	UK (NOTTINGHAM)	participant	0.00
7	UNIVERSITA DEGLI STUDI DI FIRENZE  Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 contact info Titolo: Prof. Nome: Cristina Cognome: Stefanile Email: send email Telefono: +39 055 6237828 Fax: +39 055 623607	IT (Florence)	participant	0.00
8	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Kent Cognome: Lee Email: send email Telefono: +44 20 7679 6296 Fax: +44 20 7679 6502	UK (LONDON)	participant	0.00

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 Obiettivo del progetto (Objective)

'The research program aims to understand the dynamics of the structural and functional organization of the visual cortex and the implications for amblyopia ('lazy eye', the most prevalent visual disorder among young people). We will study these fundamental issues from the molecular level all the way to the network level. To achieve this, members of the consortium have - for the first time - established chronic in vivo two photon imaging of Ca2 responses in the visual cortex by making use of a novel genetically encoded Ca2 sensor. Using this powerful new methodology we will study how experience changes firing properties of individual neurons of known identity and how this correlates with changes in inhibitory and excitatory synaptic structures. Using the same approach we will study the neuronal substrate of amblyopia and how it alters coding of visual information. Next we will study how binocular experience leads to recovery from amblyopia and how perceptual learning can improve this in animal models and human subjects. This knowledge will be directly translated into new treatments of amblyopia by one of the participating SMEs. Last we will study the molecular and cellular mechanisms that restrict plasticity in the adult visual system with the aim to achieve increased experience dependent plasticity in the adult brain. This knowledge can be used for the treatment of disorders of the CNS from which recovery is limited due to restricted plasticity. Apart from amblyopia, these include brain tumors, stroke, degenerative diseases and trauma. Together this program will provide comprehensive insight into the neuronal interactions underpinning function and dysfunction of the visual cortex and will contribute directly to improved treatment of amblyopia and development of plasticity based approaches for curing a large array of disorders of the CNS.'