MOODINFLAME

"Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system"

 Coordinatore ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Hemmo A.
Cognome: Drexhage
Email: send email
Telefono: 31107044093
Fax: 31107044731

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://moodinflame.eu/
 Totale costo 13˙761˙545 €
 EC contributo 10˙235˙585 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-11-01   -   2013-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Hemmo A.
Cognome: Drexhage
Email: send email
Telefono: 31107044093
Fax: 31107044731

NL (ROTTERDAM) coordinator 1˙641˙782.40
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Norbert
Cognome: Mueller
Email: send email
Telefono: +49 89 5160 3397
Fax: +49 89 5160 4548

DE (MUENCHEN) participant 1˙408˙500.00
3    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

 Organization address address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149

contact info
Titolo: Dr.
Nome: Katharina
Cognome: Steinberg
Email: send email
Telefono: 492518000000
Fax: 492518000000

DE (MUENSTER) participant 783˙800.00
4    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Maria
Cognome: Vereeken
Email: send email
Telefono: +32 16 326504
Fax: +32 16 326515

BE (LEUVEN) participant 583˙000.00
5    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Ms.
Nome: Silke
Cognome: Blohm
Email: send email
Telefono: +44 207 8480121
Fax: +44 207 8480671

UK (LONDON) participant 544˙000.00
6    MEDIZINISCHE UNIVERSITAET INNSBRUCK

 Organization address address: Christoph-Probst Platz 1
city: INNSBRUCK
postcode: 6020

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Hegenauer
Email: send email
Telefono: +43 512 900371004
Fax: +43 512 900373014

AT (INNSBRUCK) participant 528˙400.00
7    Foundation Biological Psychiatry

 Organization address address: Svilenitsa str 8
city: Sofia
postcode: 1463

contact info
Titolo: Dr.
Nome: Olya
Cognome: Mikova-Demireva
Email: send email
Telefono: +359 2 851 17 40
Fax: +359 851 17 40

BG (Sofia) participant 483˙500.00
8    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Ms.
Nome: Deirdre
Cognome: Savage
Email: send email
Telefono: +353 1 8961942
Fax: +353 1 7071633

IE (DUBLIN) participant 423˙882.00
9    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Mr.
Nome: J.J.
Cognome: Breeuwsma
Email: send email
Telefono: +31 50 363 8377
Fax: +31 50 363 3041

NL (GRONINGEN) participant 393˙605.20
10    Advanced Practical Diagnostics

 Organization address address: Hertoginstraat 82
city: Turnhout
postcode: 2300

contact info
Titolo: Dr.
Nome: Aye Mu
Cognome: Myint
Email: send email
Telefono: +32 14 470890
Fax: +32 14 424957

BE (Turnhout) participant 384˙100.00
11    CROSSLINKS BV

 Organization address address: WILLEMSKADE 18C
city: ROTTERDAM
postcode: 3016 DL

contact info
Titolo: Mr.
Nome: Ronald
Cognome: Nanninga
Email: send email
Telefono: +31 10 408 7491
Fax: +31 10 7044161

NL (ROTTERDAM) participant 372˙500.00
12    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Evelyne
Cognome: Lasfargues
Email: send email
Telefono: 331145000000
Fax: 33148995407

FR (PARIS) participant 372˙400.00
13    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Titolo: Mr.
Nome: Jürgen
Cognome: Dreyer
Email: send email
Telefono: +49 761 270 2081
Fax: +49 761 270 1889

DE (FREIBURG) participant 372˙400.00
14    UNIVERSITY OF BRADFORD

 Organization address address: RICHMOND ROAD
city: BRADFORD
postcode: BD7 1DP

contact info
Titolo: Mr.
Nome: Sheila
Cognome: Frye
Email: send email
Telefono: 441274000000
Fax: 441274000000

UK (BRADFORD) participant 372˙400.00
15    Affectis Phamaceuticals AG

 Organization address address: Fraunhoferstrasse 13
city: Martinsried
postcode: 82152

contact info
Titolo: Dr.
Nome: Herbert
Cognome: Stadler
Email: send email
Telefono: +49 89 8932811 104
Fax: +49 89 8932811 111

DE (Martinsried) participant 316˙835.60
16    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Ms.
Nome: Pirkko
Cognome: Boox
Email: send email
Telefono: +46 18 6110250
Fax: +46 18 558931

SE (UPPSALA) participant 286˙000.00
17    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 26434845
Fax: +39 02 26433781

IT (MILANO) participant 267˙133.00
18    Fondazione Centro San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa Pedrazzi
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845

IT (Milano) participant 251˙952.00
19    HUMANITAS MIRASOLE SPA

 Organization address address: "Via Manzoni, 56"
city: ROZZANO-MILAN
postcode: 20089

contact info
Titolo: Dr.
Nome: Marina
Cognome: Lancellotti
Email: send email
Telefono: +39 02 8224 2428
Fax: +39 02 8224 5191

IT (ROZZANO-MILAN) participant 228˙300.00
20    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Dr.
Nome: Manon
Cognome: Hillegers
Email: send email
Telefono: +31 88 7558180

NL (UTRECHT) participant 123˙394.80
21    NEWRON PHARMACEUTICALS SPA

 Organization address address: VIA LUDOVICO ARIOSTO 21
city: BRESSO
postcode: 20091

contact info
Titolo: Dr.
Nome: Patricia
Cognome: Salvati
Email: send email
Telefono: 390261000000
Fax: 390261000000

IT (BRESSO) participant 97˙700.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

models    inhibitor    individuals    biomarker    dysfunction    drugs    activated    abnormal    inflammation    anti    screening    blood    hypothesis    brain    monocytes    therapeutic    patients    disorder    moodinflame    mechanism    psychiatric    pro    irs    tryptophan    mood    immune    inflammatory    animal    disorders    rat    mouse    activation    metabolism    depressive    catabolism    outcome    tests   

 Obiettivo del progetto (Objective)

'Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammatory and tryptophan metabolism restoring drugs. B) The in-parallel study of mood disorder patients to validate two sets of already developed biomarker tests to identify patients and individuals at risk for a mood disorder and characterized by an activated IRS to be able to treat these patients/individuals with drugs counteracting the consequences of the activated IRS/disturbed catabolism of tryptophan. Five strategic approaches (broken down in 12 workpackages) are used: 1) Study of the animal models for depressive-like behavior and aberrancies in monocytes/ macrophages, the tryptophan metabolism and the microglia-astrocyte-neuron interaction. 2/3) The validation of a high-throughput biomarker mRNA blood monocyte signature test and a biomarker test to detect an abnormal tryptophan catabolism. 4) Correlation studies between the outcomes of these biomarker tests in patients to various clinical variables, a.o. gene polymorphisms and the brain scan. 5) The therapeutic targetting of the activated IRS/abnormal tryptophan catabolism using a PDE4 inhibitor, a COX-2 inhibitor and a KMO-inhibitor in the animal models and in a phase II intervention study in depressed patients. Novel approaches are the prospective assessment of patients/individuals to identify whether changes in the IRS have any prognostic value and that the program aims at a personalized treatment of patients on the basis of their activated IRS. We heavily rely in this on the study of the animal models, which allow us to test anti-inflammatory therapeutics and to know their mechanism of action at the brain.'

Introduzione (Teaser)

Accumulating evidence suggests that the neural and immune systems are tightly intertwined. With this mind, European researchers investigated the novel hypothesis that immune dysfunction could be the triggering event in mood disorders.

Descrizione progetto (Article)

An abnormal immune activation is emerging as central to the development of mood disorders. A chronic state of inflammation in certain brain areas involved in mood regulation could cause mood imbalance, as a result of hormonal or metabolic disturbance. For example, immune activation could impair the catabolism of tryptophan, an important precursor of the neurotransmitter serotonin.

The EU-funded http://moodinflame.eu/ (MOODINFLAME) study was designed to test the underlying hypothesis that many mood or psychiatric disorders are triggered by increased susceptibility to inflammation. Their objective was to study immune dysfunction in psychiatric patients and mouse models of disease and develop brain and blood scans for assessing immune dysfunction.

Large number of patient samples were analysed. Results linked mood disorder with increased numbers of monocytes expressing both pro- and anti-inflammatory genes as well as high levels of pro-inflammatory cytokines. All this data validated the overall immune dysfunction pattern in patients with mood disorders. Interestingly, an activated state of monocytes negatively determined the outcome of anti-depressant therapy.

Work in animal models of depressive-like behaviour further corroborated these findings. Animals exhibited activated inflammatory responses and an abnormal tryptophan metabolism. Scientists identified three major pathways that were implicated in the aberrant immune-endocrine interface. This abnormal communication led to structural and functional deficits of important brain regions.

Regarding therapeutic strategies, part of the MOODINFLAME work entailed the screening of various non-steroid anti-inflammatory drugs in the animal models. The PSYCH-AID project, which is an EU-funded continuation project of MOODINFLAME will continue the investigation of such drugs in patients with mood disorders.

Overall, the outcome of the study has the potential to change the way psychiatric disorders are treated. The generated diagnostic tools will be of enormous help down this path, facilitating the screening of patients with mood disorders for immune dysregulation.

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