ALLEGRO

Early and late health risks to normal/healthy tissues from the use of existing and emerging techniques for radiation therapy

 Coordinatore UNIVERSITA DEGLI STUDI DI PAVIA 

 Organization address address: STRADA NUOVA 65
city: PAVIA
postcode: 27100

contact info
Titolo: Prof.
Nome: Andrea
Cognome: Ottolenghi
Email: send email
Telefono: +39 0382 987892
Fax: +39 0382 526938

 Nazionalità Coordinatore Italy [IT]
 Sito del progetto http://www.allegroproject.eu
 Totale costo 3˙917˙300 €
 EC contributo 2˙599˙350 €
 Programma FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection
 Code Call FP7-Fission-2008
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-02-01   -   2011-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA

 Organization address address: STRADA NUOVA 65
city: PAVIA
postcode: 27100

contact info
Titolo: Prof.
Nome: Andrea
Cognome: Ottolenghi
Email: send email
Telefono: +39 0382 987892
Fax: +39 0382 526938

IT (PAVIA) coordinator 478˙440.00
2    GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH

 Organization address address: PLANCKSTRASSE 1
city: DARMSTADT
postcode: 64291

contact info
Titolo: Dr.
Nome: Johannes
Cognome: Heilmann
Email: send email
Telefono: 496160000000
Fax: 496160000000

DE (DARMSTADT) participant 350˙000.00
3    TECHNISCHE UNIVERSITAET DRESDEN

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Mr.
Nome: Sven
Cognome: Kreigenfeld
Email: send email
Telefono: +49 351 46339744
Fax: +49 351 46339742

DE (DRESDEN) participant 313˙800.00
4    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Maria
Cognome: Vereeken
Email: send email
Telefono: +32 16 326504
Fax: +32 16 326515

BE (LEUVEN) participant 260˙100.00
5    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Prof.
Nome: Johannes A.
Cognome: Langendijk
Email: send email
Telefono: +31 50 3611190
Fax: +31 50 2611692

NL (GRONINGEN) participant 243˙960.00
6    CHALMERS TEKNISKA HOEGSKOLA AB

 Organization address address: -
city: GOETEBORG
postcode: 41296

contact info
Titolo: Ms.
Nome: Annika
Cognome: Hofling
Email: send email
Telefono: +46 31 772308
Fax: +46 31 7723204

SE (GOETEBORG) participant 205˙500.00
7    PAUL SCHERRER INSTITUT

 Organization address address: Villigen
city: VILLIGEN PSI
postcode: 5232

contact info
Titolo: Ms.
Nome: Irene
Cognome: Walthert
Email: send email
Telefono: +4156 3102664
Fax: +4156 3102717

CH (VILLIGEN PSI) participant 186˙000.00
8    EUROPEAN SOCIETY FOR RADIOTHERAPY AND ONCOLOGY

 Organization address address: Avenue E Mounierlaan 83
city: BRUXELLES
postcode: 1200

contact info
Titolo: Mr.
Nome: Michel
Cognome: Taillet
Email: send email
Telefono: +32 2 775 93 40
Fax: +32 2 779 54 94

BE (BRUXELLES) participant 145˙800.00
9    AARHUS UNIVERSITETSHOSPITAL

 Organization address address: NORREBROGADE 44
city: AARHUS
postcode: 8000

contact info
Titolo: Mr.
Nome: Morten
Cognome: Busk
Email: send email
Telefono: +45 8949 2627
Fax: +45 8619 7109

DK (AARHUS) participant 130˙000.00
10    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: +49 731 500 66397
Fax: +49 731 500 66392

DE (ULM) participant 99˙000.00
11    ISTITUTO EUROPEO DI ONCOLOGIA SRL

 Organization address address: Via Filodrammatici 10
city: MILANO
postcode: 20121

contact info
Titolo: Ms.
Nome: Ilaria
Cognome: Foti
Email: send email
Telefono: +39 0257489295
Fax: +39 0294375991

IT (MILANO) participant 88˙800.00
12 East & North Hertfordshire National Health Service Trust UK participant 65˙250.00
13    UNIVERSITEIT MAASTRICHT

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Ms.
Nome: Sietske
Cognome: Satijn
Email: send email
Telefono: +31 43 3881867
Fax: +31 43 3881890

NL (MAASTRICHT) participant 32˙700.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

technological    gaps    damage    harmful    radiation    therapy    normal    models    allegro    developments    data    outcomes    limit    radiotherapy    collection    dose    conventional    patients    series    becoming    treatment    clinicians    recommendations    volume    treatments    risks    techniques    databases    tissue    healthy    documents    evident    cancer    doses   

 Obiettivo del progetto (Objective)

'Curative cancer treatment with radiation seeks to optimise the magnitude of the radiation dose to the treatment volume while restricting the dose to normal healthy tissue. With an increasing population of surviving cancer patients treated with radiation therapy, the harmful effects of the radiation to normal tissue are becoming more evident. The ALLEGRO project will address the many aspects of normal healthy tissue damage that are not yet well understood in both conventional treatment techniques and emerging techniques (protons, heavy ions). The project will include measurement of radiation doses outside the treatment volume and investigation of the accuracy of methods of dose calculation in this region. The extensive existing databases of radiation treatments and outcomes will be used to investigate models of normal tissue damage and second primary cancer. The measurements and data analysis will be supported by theoretical modelling and surveys to develop the link between radiobiological mechanisms and empirical normal tissue complication (NTCP) models, and to extend conventional models to apply to the emerging techniques. The project is restricted to two years, so there will be a limit to the amount of new research possible. Therefore an essential part of the project will be to engage a forum of experts to redefine the current knowledge on normal tissue damage following radiotherapy, identify gaps in the knowledge and make recommendations for future research, data collection, and technological developments. The final report will consist of a series of focused documents directed to clinicians (for the application of normal tissue risks in treatment optimisation), equipment manufacturers (recommendations on safety design), and the research community (summary of knowledge and recommendations on data collection and project proposals).'

Introduzione (Teaser)

Treating cancer with modern radiation therapy has proved successful and cost-effective. However, concerns remain about the damage done to healthy tissue in the process.

Descrizione progetto (Article)

When eradicating cancer cells with radiotherapy, the radiation dose delivered to surrounding normal healthy tissue must be kept in mind; the harmful effects are becoming all the more evident with cancer survivors living longer.

The 'Early and late health risks to normal/healthy tissues from the use of existing and emerging techniques for radiation therapy' (Allegro) project is working to mark gaps in knowledge, evaluate current methods of measuring and calculating dose, and recommend future directions for research, data collection and technological developments.

Bringing together 13 partners from 8 European countries, Allegro is collecting information from databases of radiation treatments and outcomes. The data will be used to study models of normal tissue damage and the emergence of radiation-induced second cancer. This will also help assess the biological effectiveness of contemporary therapies.

The project is progressing according to the original time schedule. Partners have already completed measurements of out-of-field doses while work on analyses of clinical data has been geared towards ensuring consistency of format and overall design of case-control studies.

Work in the second year of this two-year Euratom-funded study will result in a series of focused documents defining the current state of knowledge and highlighting factors that limit the confidence with which a clinician can predict normal tissue response to different treatments.

The Allegro project aims to assist clinicians making radiotherapy treatment decisions to assess the potential of medium- and long-term healthy tissue harm. This will ultimately enhance survival and after-treatment quality of life for cancer patients.

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