IRENE

In silico Rational Engineering of Novel Enzymes

 Coordinatore UNIVERSITA DEGLI STUDI DI TRIESTE 

 Organization address address: PIAZZALE EUROPA 1
city: TRIESTE
postcode: 34127

contact info
Titolo: Ms.
Nome: Edda
Cognome: Bartole
Email: send email
Telefono: +39 040 558 3904
Fax: +39 040 5583903

 Nazionalità Coordinatore Italy [IT]
 Totale costo 5˙186˙379 €
 EC contributo 1˙999˙995 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2008-2B
 Funding Scheme CP-SICA
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-04-01   -   2012-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRIESTE

 Organization address address: PIAZZALE EUROPA 1
city: TRIESTE
postcode: 34127

contact info
Titolo: Ms.
Nome: Edda
Cognome: Bartole
Email: send email
Telefono: +39 040 558 3904
Fax: +39 040 5583903

IT (TRIESTE) coordinator 520˙225.00
2    KUNGLIGA TEKNISKA HOEGSKOLAN

 Organization address address: Valhallavaegen 79
city: STOCKHOLM
postcode: 10044

contact info
Titolo: Ms.
Nome: Inger
Cognome: åhlén
Email: send email
Telefono: +46 8 5537 8403
Fax: +46 8 5537 8482

SE (STOCKHOLM) participant 363˙600.00
3    NOVOZYMES A/S

 Organization address address: Krogshoejvej 36
city: BAGSVAERD
postcode: 2880

contact info
Titolo: Mr.
Nome: Allan
Cognome: Svendsen
Email: send email
Telefono: 4530773884
Fax: +45 4498 0246

DK (BAGSVAERD) participant 343˙517.00
4    TECHNISCHE UNIVERSITEIT DELFT

 Organization address address: Stevinweg 1
city: DELFT
postcode: 2628 CN

contact info
Titolo: Mr.
Nome: Van Loghem
Cognome: Rogier
Email: send email
Telefono: +31 15 278 9695
Fax: +311527843 01

NL (DELFT) participant 333˙055.00
5 KOBENHAVNS UNIVERSITET DK participant 303˙602.00
6    BELOZERSKY INSTITUTE OF PHYSICOCHEMICAL BIOLOGY

 Organization address address: Leninskije gory 1
city: MOSCOW
postcode: 119991

contact info
Titolo: Prof.
Nome: Vytas
Cognome: Svedas
Email: send email
Telefono: 79857662279

RU (MOSCOW) participant 99˙996.00
7    THE NATIONAL UNIVERSITY OF UZBEKISTAN NAMED AFTER MIRZO ULUGBEK

 Organization address address: Vuzgorodok 174
city: TASHKENT
postcode: 100174

contact info
Titolo: Prof.
Nome: Hodjiakbar Abdurasulovich
Cognome: Toychiev
Email: send email
Telefono: 998712000000
Fax: 998712000000

UZ (TASHKENT) participant 36˙000.00
8    "BIO/ TECHOLOGIES, INNOVATIONS, RESEARCHES LTD"

 Organization address address: Leninskie gory 1/75G
city: MOSCOW
postcode: 119992

contact info
Titolo: Dr.
Nome: Igor Ivanovich
Cognome: Emelianov
Email: send email
Telefono: +7 499 136 9657
Fax: +7 495 9394653

RU (MOSCOW) participant 0.00
9    FEDERAL STATE BUDGETARY ORGANIZATION B.P. KONSTANTINOV PETERSBURG NUCLEAR PHYSICS INSTITUTE

 Organization address address: ORLOVA ROSCHA LENINGRAD DISTRICT
city: Gatchina
postcode: 188300

contact info
Titolo: Mr.
Nome: Igor
Cognome: Baranov
Email: send email
Telefono: 78137146045
Fax: 78137139917

RU (Gatchina) participant 0.00
10    MOLECULAR TECHNOLOGIES

 Organization address address: Leninskie gory 1/75A
city: MOSCOW
postcode: 119992

contact info
Titolo: Ms.
Nome: Anastasia
Cognome: Kurnosova
Email: send email
Telefono: +7 916 3074842
Fax: +7 495 9394484

RU (MOSCOW) participant 0.00
11    SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE

 Organization address address: UL. MIKLUKHO MAKLAYA 16/10
city: MOSCOW
postcode: 117997

contact info
Titolo: Prof.
Nome: Dmitry
Cognome: Dolgikh
Email: send email
Telefono: +7 495 336 80 11
Fax: +7 495 335 28 88

RU (MOSCOW) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

biocatalysts    efficient    rational    promiscuity    catalytic    screening    molecular    biocatalyst    mechanics    substrate    industry    strategies    computational    fast    enzymes    enzyme    irene    quantitative    industrial    expertise   

 Obiettivo del progetto (Objective)

'IRENE project aims at overcoming existing bottlenecks for a broader diffusion of biocatalysis and at accelerating the sustainable innovation of chemical industry by developing computational methods and strategies that will enable to rationally design and produce the next generation of biocatalysts for industrial applications. The consortium is funded on the combination of robust multidisciplinary expertise from EU, Russia and Uzbekistan. Due to the interaction between theoretical groups and experimentalists all computational tools used in this project will be validated by experiments. Failures and successes will be used for methods’ evaluation and tuning, in an iterative process that will lead to new methods but also to the definition of practical guidelines, for any specific enzyme design issue. The convergence of different expertise will face 4 main tasks: 1) fast rational design of efficient biocatalysts; 2) fast and efficient in silico screening of available enzymes/mutants to exploit catalytic potential of existing biocatalyst and providing quantitative parameters describing enzyme’s efficiency; 3) fast substrate-screening and rational substrate engineering; 4) understanding molecular basis of biocatalyst’ action and properties. IRENE will pursue these objectives by taking advantage of computational strategies used in different disciplines and integrate them in an unified concept for studying enzyme catalysis. The four main families of computational methods, Quantum Mechanics, Molecular Mechanics, Quantitative Structure Activity Relationships and Bioinformatics, will used in an integrated approach. The project will have three major design subjects: 1) introduction of new activities in specific enzyme scaffolds (reaction promiscuity); 2) improvement of catalytic activity towards specific targets (substrate promiscuity); 3) the redesign of enantioselectivity. For each subject the work will focus on different specific enzymatic activities of industrial relevance.'

Introduzione (Teaser)

Advanced ways to test and produce novel enzymes using high-tech means will help European industry to create better products, from medicines to cleaning agents.

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FOODCONFERENCE (2011)

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ANIMPOL (2010)

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FACET (2008)

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