CREATE

Coordination of resources for conditional expression of mutated mouse alleles

 Coordinatore EUROPEAN MOLECULAR BIOLOGY LABORATORY 

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Keith
Cognome: Williamson
Email: send email
Telefono: -62213878246
Fax: -6221987526

 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙287˙738 €
 EC contributo 1˙100˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CSA-CA
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-11-01   -   2011-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Keith
Cognome: Williamson
Email: send email
Telefono: -62213878246
Fax: -6221987526

DE (HEIDELBERG) coordinator 349˙750.00
2    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

 Organization address address: Al. Fleming Street 34
city: VARI-ATHENS
postcode: 16672

contact info
Titolo: Dr.
Nome: George
Cognome: Kollias
Email: send email
Telefono: -2109656477
Fax: -2109656533

EL (VARI-ATHENS) participant 294˙250.00
3    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

 Organization address address: Rue Laurent Fries 1
city: ILLKIRCH GRAFFENSTADEN
postcode: 67404

contact info
Titolo: Dr.
Nome: Steve
Cognome: Brooks
Email: send email
Telefono: -547
Fax: -455

FR (ILLKIRCH GRAFFENSTADEN) participant 155˙274.00
4    Mount Sinai Hospital

 Organization address address: University Avenue 600
city: TORONTO
postcode: M5G 1X5

contact info
Titolo: Mr.
Nome: Paul
Cognome: Kranjac
Email: send email
Telefono: -6399
Fax: -9845

CA (TORONTO) participant 85˙600.00
5    THE JACKSON LABORATORY NON PROFIT CORPORATION

 Organization address address: MAIN STREET 610
city: BAR HARBOR
postcode: 4609

contact info
Titolo: Dr.
Nome: Sven
Cognome: Davisson
Email: send email
Telefono: -2886978
Fax: -2886259

US (BAR HARBOR) participant 85˙600.00
6    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Juergen
Cognome: Ertel
Email: send email
Telefono: -6249
Fax: -7093

DE (MUENCHEN) participant 45˙475.00
7    GENOME RESEARCH LIMITED

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Mr.
Nome: David Neil
Cognome: Davison
Email: send email
Telefono: -496116
Fax: -496098

UK (LONDON) participant 42˙051.00
8    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Hilary
Cognome: Gates
Email: send email
Telefono: -842443
Fax: -842360

UK (SWINDON) participant 42˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

mutants    conditional    mutant    lines    internationally    data    systematic    cre    driver    resource    human    mutagenesis    cell    mouse    create    tissue    databases    disease    worldwide    strains    organism    critical    models   

 Obiettivo del progetto (Objective)

'This proposal describes CREATE, an internationally based Coordination Action directly addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. Advances in the sophisticated manipulation of the mouse genome has established the mouse as the premier organism for developing models of human disease. Internationally coordinated initiatives have established for the systematic generation of conditional mouse mutants on a large scale employing the Cre-lox binary system. Production of mutant mouse ES cell lines, each of which carries an altered or “floxed” allele of a single gene allows the creation of somatic mutations in defined genes. The full power of conditional mutants can only be exploited with the availability of well characterised mouse lines expressing Cre-recombinase in tissue, organ and cell type-specific patterns. Although several privately curated and locally held databases currently provide a limited catalog of existing Cre driver strains, these are not well integrated, and published data on Cre driver mice do not always capture critical details. CREATE will address these these combined shortcomings - inaccessibility to existing Cre driver strains, their incomplete characterisation, and an inadequate coverage of cell and tissue types in which they are active – which will soon constitute the major bottleneck for the future development of targeted conditional mutant models for the worldwide mouse mutagenesis initiative. Its main deliverables will be a well-annotated and integrated data resource of Cre driver strains, and coordination of the expansion of the resource, both necessary components of the international mouse mutagenesis effort. By enlisting major mouse stakeholders dedicated to collecting, integrating and curating, expanding and disseminating Cre driver mouse databases through a unified web portal, CREATE will provide the necessary structure for worldwide access to these critical resources.'

Introduzione (Teaser)

The mouse is today the main organism used for developing models of human disease. The potential for long-term benefits of this calls for standardised production and use of mouse mutants.

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