ENPRA
RISK ASSESSMENT OF ENGINEERED NANOPARTICLES
| Coordinatore | INSTITUTE OF OCCUPATIONAL MEDICINE
Organization address
address: Research Avenue North, Riccarton 45 contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Sito del progetto | http://www.enpra.eu |
| Totale costo | 5˙269˙000 € |
| EC contributo | 3˙700˙000 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2008-SMALL-2 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-05-01 - 2012-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUTE OF OCCUPATIONAL MEDICINE
Organization address
address: Research Avenue North, Riccarton 45 contact info |
UK (EDINBURGH) | coordinator | 400˙680.00 |
| 2 |
RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN
Organization address
address: Antonie Van Leeuwenhoeklaan 9 contact info |
NL (BILTHOVEN) | participant | 351˙402.00 |
| 3 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 290˙333.00 |
| 4 |
UNIVERSITA CA' FOSCARI VENEZIA
Organization address
address: DORSODURO 3246 contact info |
IT (VENEZIA) | participant | 286˙025.00 |
| 5 |
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Organization address
address: Rue de la Loi 200 contact info |
BE (BRUSSELS) | participant | 281˙757.00 |
| 6 |
DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO
Organization address
address: LERSO PARKALLE 105 contact info |
DK (KOBENHAVN) | participant | 271˙300.00 |
| 7 |
VRIJE UNIVERSITEIT BRUSSEL
Organization address
address: PLEINLAAN 2 contact info |
BE (BRUSSEL) | participant | 260˙559.00 |
| 8 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | participant | 217˙810.00 |
| 9 |
UNIVERSITE PARIS DIDEROT - PARIS 7
Organization address
address: RUE THOMAS MANN 5 contact info |
FR (PARIS) | participant | 200˙726.00 |
| 10 |
INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH
Organization address
address: AUF M HENNEKAMP 50 contact info |
DE (DUESSELDORF) | participant | 194˙889.00 |
| 11 |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address
address: Oude Markt 13 contact info |
BE (LEUVEN) | participant | 194˙889.00 |
| 12 | KOBENHAVNS UNIVERSITET | DK | participant | 194˙889.00 |
| 13 |
UNIVERSITE CATHOLIQUE DE LOUVAIN
Organization address
address: Place De L'Universite 1 contact info |
BE (LOUVAIN LA NEUVE) | participant | 194˙889.00 |
| 14 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 168˙298.00 |
| 15 |
HERIOT-WATT UNIVERSITY
Organization address
address: Riccarton contact info |
UK (EDINBURGH) | participant | 153˙186.00 |
| 16 |
EDINBURGH NAPIER UNIVERSITY
Organization address
address: COLINTON ROAD 219 contact info |
UK (EDINBURGH) | participant | 38˙368.00 |
| 17 |
DUKE UNIVERSITY
Organization address
address: BLACKWELL ST SUITE 920 324 contact info |
US (DURHAM) | participant | 0.00 |
| 18 |
UNIVERSITY OF ROCHESTER
Organization address
address: "ELMWOOD AVENUE, BOX EHSC 601" contact info |
US (ROCHESTER NY) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Engineered Nanoparticles (ENP) are increasingly produced for use in a wide range of industrial and consumer products. Yet it is known that exposure to some types of particles can cause severe health effects. Therefore it is essential to ascertain whether exposure to ENP can lead to possible health risks for workers and consumers. We have formed a consortium of well-known scientists from European Universities and Research Institutes, with over 100 publications in the field of Nanotoxicology. Our aim is to develop an approach for the Risk Assessment of ENP (ENPRA). Our objectives are: (i) to obtain a bank of commercial ENP with contrasting physico-chemical characteristics and measure them; (ii) to investigate the toxic effects of ENP on 5 (pulmonary, hepatic, renal, cardiovascular and developmental) target systems and 5 endpoints (oxidative stress, inflammation; immuno-toxicity; fibrogenecity; genotoxicity) using in vitro animal/human models; (iii) to validate the in vitro findings with a small set of carefully chosen in vivo animal experiments; (iv) to construct mathematical models to extrapolate the exposure-dose-response relationship from in vitro to in vivo and to humans; (v) to use QSAR like models to identify the key ENP characteristics driving the adverse effects; (vi) to implement a risk assessment of ENP using the Weight-of-Evidence approach; (vii) to disseminate our findings to potential stakeholders. To harmonise the research activities between our EU group and the US, we have established links with scientists from US Universities (Duke, Rochester) and Government Agencies (NIH/NIEHS, NIOSH and EPA) with on-going research in Nanotoxicology. Our objectives here are (vii) to share information and agree on experimental protocols; (viii) to avoid duplication of work; (ix) to further validate the findings of this proposed study.'
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