VIRUS ENTRY

Molecular Mechanisms of Cell Entry of Enveloped Viruses

 Coordinatore HUMBOLDT-UNIVERSITAT ZU BERLIN 

 Organization address address: UNTER DEN LINDEN 6
city: BERLIN
postcode: 10099

contact info
Titolo: Mr.
Nome: Ulrich
Cognome: Winderl
Email: send email
Telefono: 493021000000
Fax: 493021000000

 Nazionalità Coordinatore Germany [DE]
 Totale costo 3˙844˙983 €
 EC contributo 3˙844˙983 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-ITN-2008
 Funding Scheme MC-ITN
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-10-01   -   2013-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HUMBOLDT-UNIVERSITAT ZU BERLIN

 Organization address address: UNTER DEN LINDEN 6
city: BERLIN
postcode: 10099

contact info
Titolo: Mr.
Nome: Ulrich
Cognome: Winderl
Email: send email
Telefono: 493021000000
Fax: 493021000000

DE (BERLIN) coordinator 557˙486.00
2    UNIVERSITEIT UTRECHT

 Organization address address: Heidelberglaan 8
city: UTRECHT
postcode: 3584 CS

contact info
Titolo: Mr.
Nome: Ricardo
Cognome: Fernandez
Email: send email
Telefono: 31302532559
Fax: 31302532333

NL (UTRECHT) participant 809˙040.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH

 Organization address address: Raemistrasse 101
city: ZUERICH
postcode: 8092

contact info
Titolo: Prof.
Nome: Ari
Cognome: Helenius
Email: send email
Telefono: +41 44 632 68 17
Fax: +41 44 632 12 69

CH (ZUERICH) participant 454˙486.00
4    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: 97236408774
Fax: 97236409697

IL (TEL AVIV) participant 424˙700.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Dr.
Nome: Michèle
Cognome: Saumon
Email: send email
Telefono: 33169823030
Fax: 33169823333

FR (PARIS) participant 401˙904.00
6    FREIE UNIVERSITAET BERLIN

 Organization address address: Kaiserswertherstrasse 16-18
city: BERLIN
postcode: 14195

contact info
Titolo: Dr.
Nome: Michael
Cognome: Veit
Email: send email
Telefono: 493021000000
Fax: 493021000000

DE (BERLIN) participant 393˙807.00
7    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Prof.
Nome: Felix
Cognome: Rey
Email: send email
Telefono: +33 1 45 68 85 63
Fax: +33 1 45 68 89 93

FR (PARIS CEDEX 15) participant 364˙117.00
8    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Ingwar
Cognome: Lennerfors
Email: send email
Telefono: 4686089223
Fax: 4686089280

SE (STOCKHOLM) participant 240˙341.00
9    Capsulution Pharma AG

 Organization address address: VOLMERSTRASSE 7B
city: Berlin
postcode: 12489

contact info
Titolo: Mr.
Nome: Alexander
Cognome: Herrmann
Email: send email
Telefono: +49 30 67069190
Fax: +49 30 67069101

DE (Berlin) participant 199˙102.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

fusion    conformational    molecular    cells    groups    network    viral    theoretical    proteins    experimental    training    virus    entry    complementary    biology    cell    viruses    cellular    industrial   

 Obiettivo del progetto (Objective)

'Virus infections are a major cause of diseases and death among men and animals. The recent outbreak of SARS and the danger that an avian influenza virus may become pandemic, have clearly shown that members of any virus family can potentially turn into a pathogen. To combat virus infection and propagation, systematic and comprehensive studies both on viral components mediating virus-cell interactions, and on the cell biology behind virus entry are necessary. Our network, teaming academic and industrial groups, is aimed at undertaking an interdisciplinary effort to reveal the diversity of pathways and associated molecular mechanisms of cell entry of enveloped viruses. Research by experimental and theoretical approaches will be directed towards the identification of cellular receptors and of viral fusion proteins responsible for interaction with host cells. Among topics are folding, three-dimensional structure and conformational changes of viral fusion proteins as well as virus triggered signalling cascades in cells. Biophysical approaches will unravel the relationship between energetics of conformational changes of viral proteins and membrane bending and fusion. Together with industrial partners the project will identify potential targets for designed drug development, and will develop virus protein coated nanoparticles as new biotechnological and medical tools. The groups have complementary expertise at the highest standard in all required techniques of virology, molecular and cellular biology, biochemistry, proteomics, structural biology, theoretical and experimental biophysics. A challenging research and training environment in an international setting will provide young scientists with a network wide research-oriented training devoted to the specific aspects of virus entry and to structuring of industry projects and commercial exploitation of results, and a local training in soft skills and basic complementary education adapted to the personal needs.'

Introduzione (Teaser)

Understanding how different viruses mediate entry into a cell is central for designing antiviral strategies.

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