SENESCENCE THERAPY

"""PRO –SENESCENCE” THERAPY IN PEDIATRIC BRAIN TUMORS"

 Coordinatore Ente Ospedaliero Cantonale 

 Organization address address: Vialle Officina 3
city: Bellinzona
postcode: CH-6500

contact info
Titolo: Mr.
Nome: Gianfranco
Cognome: Bozzini
Email: send email
Telefono: 41918119131

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-3-IRG
 Funding Scheme MC-IRG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-02-23   -   2013-02-22

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Ente Ospedaliero Cantonale

 Organization address address: Vialle Officina 3
city: Bellinzona
postcode: CH-6500

contact info
Titolo: Mr.
Nome: Gianfranco
Cognome: Bozzini
Email: send email
Telefono: 41918119131

CH (Bellinzona) coordinator 100˙000.00
2    "PROVINCIA RELIGIOSA DI SAN PIETRO DELL'ORDINE OSPEDALIERO DI SAN GIOVANNI DI DIO, DETTO FATEBENEFRATELLI"

 Organization address address: Via Cassia 600
city: ROMA
postcode: 189

contact info
Titolo: Dr.
Nome: Vittorio
Cognome: Cirucci
Email: send email
Telefono: 390634000000

IT (ROMA) participant 100˙000.00

Mappa


 Word cloud

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discuss    induced    cellular    senescence    pics    inactivation    cells    mechanism    pten    tumour    occurs    cancer   

 Obiettivo del progetto (Objective)

'The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans. We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo. Pten induced cellular senescence (PICS) occurs at early time points after Pten inactivation even in absence of cellular proliferation and DNA Damage. I will discuss the mechanism that trigger PICS in cancer, hailing the potential therapeutic implication of p53 stabilizing drugs and Pten inhibitors. Importantly, I will discuss how the oncogenic stress induced by complete loss of Pten can still triggers senescence in cells with low proliferative potential, such as cancer stem cells. I propose to apply this model to the treatment of pediatric brain tumors.'

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