TORNADO

Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health

 Coordinatore KAROLINSKA INSTITUTET 

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: åsa
Cognome: Edström
Email: send email
Telefono: +46-8-524 871 40
Fax: -

 Nazionalità Coordinatore Sweden [SE]
 Sito del progetto http://www.fp7tornado.eu
 Totale costo 7˙771˙046 €
 EC contributo 5˙895˙601 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-2A
 Funding Scheme CP-IP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-09-01   -   2014-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: åsa
Cognome: Edström
Email: send email
Telefono: +46-8-524 871 40
Fax: -

SE (STOCKHOLM) coordinator 1˙202˙896.00
2    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Katri
Cognome: Kurvinen
Email: send email
Telefono: +358 20 7223303
Fax: +358 20 7223365

FI (ESPOO) participant 628˙426.00
3    UNIVERSITE DE LAUSANNE

 Organization address city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Walter
Cognome: Wahli
Email: send email
Telefono: +41 (0)21 692 41 10
Fax: +41 (0)21 692 41 15

CH (LAUSANNE) participant 554˙932.00
4    INSTITUTE OF FOOD RESEARCH

 Organization address address: "Norwich Research Park, Colney"
city: NORWICH
postcode: NR47UA

contact info
Titolo: Dr.
Nome: Mary
Cognome: Anderson
Email: send email
Telefono: -451803
Fax: -452446

UK (NORWICH) participant 523˙039.00
5    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) participant 494˙932.00
6    UMEA UNIVERSITET

 Organization address address: UNIVERSITETOMRADET
city: UMEA
postcode: 901 87

contact info
Titolo: Ms.
Nome: Anna
Cognome: Nordström
Email: send email
Telefono: +46 (0) 90 7852272
Fax: +46 (0)90 123728

SE (UMEA) participant 351˙216.00
7    DEBRECENI EGYETEM

 Organization address address: EGYETEM TER 1
city: DEBRECEN
postcode: 4032

contact info
Titolo: Ms.
Nome: Aniko
Cognome: Kiss
Email: send email
Telefono: -417175
Fax: -592

HU (DEBRECEN) participant 261˙216.00
8    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Dr.
Nome: Margareta
Cognome: Ahlqwist
Email: send email
Telefono: +46 31 786 5345
Fax: +46 31-786 4355

SE (GOETEBORG) participant 261˙216.00
9    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Titolo: Mr.
Nome: Don
Cognome: Van Velzen
Email: send email
Telefono: +31 (0)30 - 2121800
Fax: +31 (0)30 - 2121865

NL (AMSTERDAM) participant 261˙216.00
10    QUEEN MARY UNIVERSITY OF LONDON

 Organization address address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
Titolo: Ms.
Nome: Tanya
Cognome: Szendeffy
Email: send email
Telefono: +44 20 7882 7266
Fax: +44 20 7882 7276

UK (LONDON) participant 261˙216.00
11    DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE

 Organization address address: Arthur-Scheunert-Allee 114-116
city: NUTHETAL
postcode: 14558

contact info
Titolo: Dr.
Nome: Judith
Cognome: Schaefer
Email: send email
Telefono: +49 33200 88 292
Fax: +49 33200 88 509

DE (NUTHETAL) participant 211˙216.00
12    REGION HOVEDSTADEN

 Organization address address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400

contact info
Titolo: Ms.
Nome: Kate
Cognome: Livemore
Email: send email
Telefono: +45 33 38 38 85
Fax: -33324195

DK (HILLEROD) participant 196˙416.00
13    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Hans
Cognome: Demmelmair
Email: send email
Telefono: 498952000000
Fax: 498952000000

DE (MUENCHEN) participant 189˙180.00
14    OLA AND MARTIN STEINBERG HOLDING AB

 Organization address address: TOPELIUSVAEGEN 3
city: BROMMA
postcode: 16761

contact info
Titolo: Mr.
Nome: Martin
Cognome: Steinberg
Email: send email
Telefono: +46 709 512068
Fax: NA

SE (BROMMA) participant 100˙000.00
15    ARLA FOODS AMBA

 Organization address address: SKANDERBORGVEJ 277
city: VIBY J
postcode: 8260

contact info
Titolo: Mr.
Nome: Robert
Cognome: Svanberg
Email: send email
Telefono: +46 8 6773214
Fax: +46 8 789 53 14

DK (VIBY J) participant 65˙808.00
16    SOREDAB SAS

 Organization address address: LA TREMBLAYE
city: LA BOISSIERE
postcode: 78125

contact info
Titolo: Mr.
Nome: Michel
Cognome: Foucher
Email: send email
Telefono: 33134943713
Fax: 33134943702

FR (LA BOISSIERE) participant 65˙808.00
17    HELSINGIN YLIOPISTO

 Organization address address: YLIOPISTONKATU 4
city: HELSINGIN YLIOPISTO
postcode: 14

contact info
Titolo: Ms.
Nome: Tiina
Cognome: Berg
Email: send email
Telefono: +358 9 1912 5129
Fax: +358 9 1912 5044

FI (HELSINGIN YLIOPISTO) participant 65˙304.00
18    VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA

 Organization address address: KIINAMYLLYNKATU 4-8
city: TURKU
postcode: 20520

contact info
Titolo: Mr.
Nome: Risto
Cognome: Laalo
Email: send email
Telefono: +358-2-313 1100
Fax: +358-2-313 3120

FI (TURKU) participant 65˙304.00
19    Scandinavian Clinical Nutrition i Sverige AB

 Organization address city: Stockholm
postcode: 113 59

contact info
Titolo: Mr.
Nome: Henrik
Cognome: Andersson
Email: send email
Telefono: +46 8 586 107 80
Fax: +46 8 31 99 30

SE (Stockholm) participant 43˙536.00
20    STORKBIO

 Organization address address: LAKI 25
city: TALLINN
postcode: 12915

contact info
Titolo: Ms.
Nome: Kristi
Cognome: Kurg
Email: send email
Telefono: +372 660 4793
Fax: +372 660 4793

EE (TALLINN) participant 43˙536.00
21    CYCLOLAB CIKLODEXTRIN KUTATO-FEJLES

 Organization address address: Illatos 7
city: Budapest
postcode: 1097

contact info
Titolo: Dr.
Nome: Erzsebet
Cognome: Szilagyi
Email: send email
Telefono: -6382
Fax: -6380

HU (Budapest) participant 32˙736.00
22    OY FOODFILES LTD

 Organization address address: Neulaniementie 2 L 6
city: KUOPIO
postcode: 70210

contact info
Titolo: Dr.
Nome: Essi
Cognome: Sarkkinen
Email: send email
Telefono: +358 17 2881261
Fax: +358 17 2881269

FI (KUOPIO) participant 16˙452.00
23    INBIO OU

 Organization address address: AKADEEMIA TEE 15
city: TALLINN
postcode: 12618

contact info
Titolo: Mr.
Nome: Harri
Cognome: Peiker
Email: send email
Telefono: +372 6204353
Fax: +372 6204358

EE (TALLINN) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

regimes    human    guidelines    intestinal    scientists    food    immunity    genes    tornado    evidence    molecular    population    habits    impact    functional    mouse    microbe    composition    scientific    health    determine    microbiota    bacteria    beneficial    data    substantiate    tissue    accelerate    dietary    claims    disease    tolerance    treatment    regulation    groups    systemic    influence    healthy    preventive    regulating    group    diet    gut    related    flora    cell    immune   

 Obiettivo del progetto (Objective)

'Europe is facing major diet related health problems. Attitudes to eating habits have to be changed and the benefits of alternative treatment regimes substantiated. This can only be achieved by providing guidelines regulating health claims based on scientific data. Thus, there is a unique opportunity to use gut flora in potential treatment regimes and as a preventive target for major diet related health problems. TORNADO consortium proposes a systemic and comprehensive mechanistic approach to deliver scientific data that can be compiled as guidelines for European authorities. TORNADO will determine the influence of diet on the gut flora and highlight the impact of gut flora on the immune system/other organ systems. TORNADO aims to investigate molecular targets that are subject to regulation by gut flora and diet that sustain health. This will be done by an increasing level of specificity, from (1) investigations of dietary habits and health in population cohorts, through (2) intervention studies in humans and animals and (3) analyses of the intestine and immune system, and also organs like adipocyte tissue, liver & brain, to pinpointing the impact of dietary influence on (4) cells and (5) potential functional molecular targets. TORNADO will deliver data that can be used to recommend biomarkers for evaluating effects of diet or microbes; refute, substantiate or improve health claims of existing products; generate novel functional food products. TORNADO's approach of microbe-to-mouse-to-man validation of dietary influence will enable more solid evidence for health claims and provide concrete deliverables e.g. Roadmaps to Health, Tailor-made Health-monitoring. Continuous state-of-the-art dissemination programs will increase impact. TORNADO's program will accelerate future design of personalized functional food for specific target groups. The evidence-based data delivered by TORNADO will have long lasting effects on health among European citizens well beyond 2012.'

Introduzione (Teaser)

A major cornerstone in preventive medicine could be healthy gut flora. An EU project, Tornado, is undergoing research to provide guidelines regulating health claims on this promising avenue to better health.

Descrizione progetto (Article)

Diet-related health issues are manifesting themselves even in the youth of Europe. These include diabetes, cancer and cardiovascular disease. One possible way to remedy this problem is to involve manipulation of gut flora in potential treatment regimes. Experts from interdisciplinary fields worked with the food industry so Tornado could present a thorough assessment of underlying mechanisms attached to dietary products compared to more traditional approaches.

Tornado researchers bolstered their research data by using existing relevant European groups of people belonging to three major age groups and including a twin and a birth cohort. A comprehensive databank containing details of microbial composition, serum metabolome, clinical data and dietary records was put together using the trial groups.

Tornado also established a human tissue repository bank to investigate postnatal gut microbiota cross-talk. The development of oral tolerance or systemic lack of immune response against food and commensal bacteria, a feature of intestinal immunity, was investigated. Using laser-capture microscopy of sections of human gut tissue, a large group of genes thought to be involved in immunity, metabolism and cell fate are being studied.

Lactobacillus features highly in the research agenda and the Tornado team are assessing if the probiotic has beneficial long-term effects on allergic disease occurrence by influencing the composition of gut flora. There is evidence that there is a strong link between coeliac disease and gut microbiota, and project scientists have undertaken a comprehensive study of the composition of the microbiome in children with the condition. Another research target was to determine the impact of diet, particularly high-meat and low-fibre, on intestinal flora and obesity markers in a group of healthy adults.

Gut microbiota can have an effect on the regulation of target genes and signalling pathways. To investigate this important phenomenon, the scientists have developed several microbe-free mouse models that are deficient in key receptors and genes.

Results from the Tornado project include evidence that gram negative bacteria can prompt an increase in insulin resistance. Furthermore, different dairy components were shown to have an impact on gut microbiota, glucose tolerance and overall white adipose tissue in mice obese due to diet. It is also highly likely that the study will show that a single bacterial species can have significant effects on intestinal peripheral (T cell) immune responses.

Tornado research will help to implement beneficial changes in the health status of the population as a whole. By tackling the health problems ascribed to incorrect diet by educating the public, starting at school level, the social and financial costs of the disease burden can be significantly reduced. The work also promises to deliver first-class knowledge to substantiate claims of health products such as probiotics. Overall, Tornado will be able to develop a platform to accelerate personalised diets for target groups such as the elderly.

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