NANODIARA

Development of novel nanotechnology based diagnostic systems for Rheumatoid Arthritis and Osteoarthritis

 Coordinatore European Academy of Technology and Innovation Assessment 

 Organization address city: Bad Neuenahr-Ahrweiler
postcode: 53474

contact info
Titolo: Ms.
Nome: Anja
Cognome: Schlochtermeier
Email: send email
Telefono: +49 2641 973309
Fax: +49 2641 973320

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.nanodiara.eu
 Totale costo 12˙247˙052 €
 EC contributo 8˙917˙307 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2008-LARGE-2
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-02-01   -   2014-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    European Academy of Technology and Innovation Assessment

 Organization address city: Bad Neuenahr-Ahrweiler
postcode: 53474

contact info
Titolo: Ms.
Nome: Anja
Cognome: Schlochtermeier
Email: send email
Telefono: +49 2641 973309
Fax: +49 2641 973320

DE (Bad Neuenahr-Ahrweiler) coordinator 453˙989.50
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Fraessdorf
Email: send email
Telefono: +49 30 450 576024
Fax: +49 30 450 576954

DE (BERLIN) participant 1˙158˙714.40
3    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Heinrich
Cognome: Hofmann
Email: send email
Telefono: +41 21 6933607
Fax: +41 21 6933089

CH (LAUSANNE) participant 1˙014˙883.60
4    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Jean-Paul
Cognome: Vallee
Email: send email
Telefono: +41 22 3727035
Fax: +41 22 3727072

CH (GENEVE) participant 913˙110.40
5    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Prof.
Nome: Dick
Cognome: Heinegård
Email: send email
Telefono: +46 46 2228571
Fax: +46 46 2113417

SE (LUND) participant 853˙409.60
6    MATSEARCH CONSULTING HOFMANN

 Organization address address: Chemin Jean Pavillard 14
city: Pully
postcode: 1009

contact info
Titolo: Dr.
Nome: Margarethe
Cognome: Hofmann-Amtenbrink
Email: send email
Telefono: +41 21 7290155
Fax: +41 21 7290155

CH (Pully) participant 687˙904.00
7    Arrayon Biotechnology SA

 Organization address address: Jaquet-Droz 1
city: Neuchatel
postcode: 2002

contact info
Titolo: Dr.
Nome: Hans
Cognome: Sigrist
Email: send email
Telefono: +41 32 7205292
Fax: +41 32 7205716

CH (Neuchatel) participant 651˙691.20
8    CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT

 Organization address address: RUE JAQUET DROZ 1
city: NEUCHATEL
postcode: 2007

contact info
Titolo: Dr.
Nome: Helmut
Cognome: Knapp
Email: send email
Telefono: +41 41 6727523
Fax: +41 41 6727500

CH (NEUCHATEL) participant 574˙596.50
9    STICHTING KATHOLIEKE UNIVERSITEIT

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Mr.
Nome: Wim
Cognome: Van Oijen
Email: send email
Telefono: +31 24 3618937
Fax: +31 24 3540529

NL (NIJMEGEN) participant 574˙149.20
10    ANAMAR AB

 Organization address address: KUNGSPORTSAVENYN 22
city: GOTEBORG
postcode: 411 36

contact info
Titolo: Dr.
Nome: Jan
Cognome: Hed
Email: send email
Telefono: +46 706490507
Fax: +46 317324149

SE (GOTEBORG) participant 479˙134.80
11    TARTU ULIKOOL

 Organization address address: ULIKOOLI 18
city: TARTU
postcode: 50090

contact info
Titolo: Prof.
Nome: Agu
Cognome: Tamm
Email: send email
Telefono: +372 7319341
Fax: +372 7318625

EE (TARTU) participant 474˙265.60
12    MERCK SERONO SA

 Organization address address: Chemin des Mines 9
city: GENEVE
postcode: 1202

contact info
Titolo: Dr.
Nome: Michel
Cognome: Dreano
Email: send email
Telefono: -4149225
Fax: -4143040

CH (GENEVE) participant 416˙017.60
13    PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG

 Organization address address: STRUBERGASSE 21
city: SALZBURG
postcode: 5020

contact info
Titolo: Prof.
Nome: Felix
Cognome: Eckstein
Email: send email
Telefono: +43 662 442002 1240
Fax: +43 662 442002 1240

AT (SALZBURG) participant 392˙000.00
14    UNIVERSITE DE FRIBOURG

 Organization address address: AVENUE DE L'EUROPE 20
city: FRIBOURG
postcode: 1700

contact info
Titolo: Ms.
Nome: Monique
Cognome: Bersier-Lambelet
Email: send email
Telefono: +41 263007003
Fax: +41 263009600

CH (FRIBOURG) participant 177˙783.60
15    MERCK CHIMIE SAS

 Organization address address: Carnot 201
city: Fontenay sous Bois
postcode: 94120

contact info
Titolo: Dr.
Nome: Richard
Cognome: Vidal
Email: send email
Telefono: +33 2 38304395
Fax: +33 2 38302732

FR (Fontenay sous Bois) participant 95˙657.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

living    sensitive    imaging    detection    nanodiara    diseases    mri    diagnostic    responders    spions    abundance    cells    nanoparticles    spion    events    rheumatoid    ra    population    sensitivity    biomarkers    vivo    arthritis    progressors    progression    molecular    superparamagnetic    moieties    oa    disease    significant    particles    detect    inflammatory    clinical    nanoparticle    identification    binding    onset    diagnosis    specificity    osteoarthritis    joint    disorders    treatment   

 Obiettivo del progetto (Objective)

'Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in ≈ 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need.'

Introduzione (Teaser)

The detection of arthritis currently relies on the identification of structural damages. A European project is measuring disease progression rather than its outcome.

Descrizione progetto (Article)

Rheumatoid arthritis and osteoarthritis are both inflammatory disorders that lead to the progressive deterioration of joint function. For treatment to be effective, it is of paramount importance to detect the onset of these diseases early and monitor their progression over time. However, current methods lack the sensitivity and specificity required to detect the early inflammatory events of arthritis.

Seeking to address this, the EU-funded NANODIARA project aims to develop a novel technology capable of detecting the early molecular processes that cause the onset and progression of arthritis. This technology is based on the use of functionalised nanoparticles for imaging the inflammatory events in the musculoskeletal system. Standard operating procedures have been formulated for the development of nanoparticles and the characterisation of their interaction with living cells.

Work towards the identification of novel disease biomarkers will be used to coat superparamagnetic iron oxide nanoparticles (SPIONs) with binding moieties targeted to specific cells. The plan is to use these nanoparticles to detect and identify low-abundance biomarkers associated with arthritis. So far, SPIONs coated with amino-polyvinyl alcohol (PVA) have been used to detect macrophages in the joint by magnetic resonance imaging (MRI) research after treatment with dexamethasone.

Toxicology studies are being given particular attention as they will form the basis for the clinical application and commercial exploitation of these nanoparticle formulations. For this purpose, researchers have tested SPIONs on the viability and functionality of various cell types, including immune cells. Investigation of the biodistribution of these particles has not revealed any significant side-effects following their in vivo administration.

Additionally, the consortium is developing sensitive diagnostic assays for blood and urine based on the expression of novel biomarkers. When combined with the targeted nanoparticle technology, the NANODIARA proposed approach promises a sensitive method for the diagnosis and monitoring of arthritis-related disorders.

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