ADIPOA
ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS
| Coordinatore | CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
Organization address
address: Avenue du Doyen Gaston Giraud 191 contact info |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 12˙083˙457 € |
| EC contributo | 9˙224˙472 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2009-single-stage |
| Funding Scheme | CP-IP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-01-01 - 2014-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
Organization address
address: Avenue du Doyen Gaston Giraud 191 contact info |
FR (MONTPELLIER) | coordinator | 2˙167˙455.00 |
| 2 |
UNIVERSITATSKLINIKUM ERLANGEN
Organization address
address: Maximiliansplatz 2 contact info |
DE (ERLANGEN) | participant | 889˙944.00 |
| 3 |
JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG
Organization address
address: SANDERRING 2 contact info |
DE (WUERZBURG) | participant | 848˙150.00 |
| 4 |
ISTITUTO ORTOPEDICO RIZZOLI
Organization address
address: VIA DI BARBIANO 1/10 contact info |
IT (BOLOGNA) | participant | 769˙750.00 |
| 5 |
MRB Forschungszentrum fur Magnet-Resonanz-Bayern e.V.
Organization address
address: Am Hubland contact info |
DE (Wuerzburg) | participant | 693˙440.00 |
| 6 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | participant | 636˙320.00 |
| 7 |
ETABLISSEMENT FRANCAIS DU SANG
Organization address
address: AVENUE DU STADE DE FRANCE 20 contact info |
FR (LA PLAINE SAINT DENIS CEDEX) | participant | 634˙687.00 |
| 8 |
VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS
Organization address
address: ZYGIMANTU 9 contact info |
LT (VILNIUS) | participant | 596˙712.00 |
| 9 |
PROCORE LTD
Organization address
address: GOLDA MEIR 7 WEIZMANN SCIENCE PARK 7 contact info |
IL (NES ZIONA) | participant | 576˙600.00 |
| 10 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 548˙098.00 |
| 11 |
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Organization address
address: University Road - contact info |
IE (GALWAY) | participant | 477˙616.00 |
| 12 |
Laboratoires MABIO International
Organization address
address: du Pont Rompu 96 contact info |
FR (Tourcoing) | participant | 385˙700.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experience on cell therapy, logistic and production facilities for adipose derived stromal cells (ASC) and clinical studies focusing on cartilage repair. They have shown that stromal cells have anti-inflammatory and antiapoptosis effets, prevent cells from senescence and protect endogenous cells from oxidative stress. ASC are well described, and the procedure to expand the ASC in GMP clinical grade by one of us has been approved by regulatory authorities. This has prompted us to propose an original and innovative regenerative medicine approach for OA in a four years programme organised around 6 workpackages : · WP 1 ASC biology, cell processing & optimization for chondral protection · WP 2 In vivo validation of chondroprotective effect of ASC · WP 3 Safety, Security & regulatory issues · WP 4 Clinical trial endogenous ASC injected intraarticular in OA · WP 5 Management and Coordination · WP 6 Training and Education ADIPOA project will then lead to the optimisation and standardisation of production procedures. In vivo validation and optimisation shall lead to a phase 1 clinical trial and the design and initiation of a phase 2 controlled study in OA. The ADIPOA Consortium comprises 10 academic and 2 sme participants and gathers researchers and clinicians with expertise in clinical research, chondrocytes and adipose stem cell biology and regenerative medicine. The Sme participation will ensure the dissemination of the project results. The critical mass achieved by the ADIPOA Consortium should enable clinical applications in OA.'
Introduzione (Teaser)
Knee osteoarthritis (OA) affects millions of people in Europe with improved mobility possible only through knee arthroplasty, a surgical procedure. Fat-derived stem cells could prove to be a better solution.