IDEA

Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

 Coordinatore HOSPICES CANTONAUX CHUV 

 Organization address address: Rue du Bugnon 21
city: LAUSANNE
postcode: 1005

contact info
Titolo: Prof.
Nome: Giuseppe
Cognome: Pantaleo
Email: send email
Telefono: 41213141071
Fax: 41213141070

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 13˙728˙795 €
 EC contributo 10˙300˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-single-stage
 Funding Scheme CP-IP-SICA
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-03-01   -   2015-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HOSPICES CANTONAUX CHUV

 Organization address address: Rue du Bugnon 21
city: LAUSANNE
postcode: 1005

contact info
Titolo: Prof.
Nome: Giuseppe
Cognome: Pantaleo
Email: send email
Telefono: 41213141071
Fax: 41213141070

CH (LAUSANNE) coordinator 1˙623˙442.00
2    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Ms.
Nome: Josephine
Cognome: Magoba-Makuyi
Email: send email
Telefono: +256 417 704000
Fax: +256 414 321137

UK (SWINDON) participant 1˙449˙987.00
3    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Prof.
Nome: Thomas Hm
Cognome: Thm Ottenhoff
Email: send email
Telefono: 31715262620
Fax: 31715266758

NL (LEIDEN) participant 1˙042˙910.00
4    SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT

 Organization address address: SOCINSTRASSE 57
city: Basel
postcode: CH-4002

contact info
Titolo: Prof.
Nome: Marcel
Cognome: Tanner
Email: send email
Telefono: +41 61 2848287
Fax: +41 61 2848101

CH (Basel) participant 840˙453.75
5    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Prof.
Nome: Adrian
Cognome: Hill
Email: send email
Telefono: 441866000000
Fax: 441866000000

UK (OXFORD) participant 804˙100.00
6    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

 Organization address address: KEPPEL STREET
city: LONDON
postcode: WC1E7HT

contact info
Titolo: Ms.
Nome: Jana
Cognome: Sabinovska
Email: send email
Telefono: 442079000000
Fax: 442076000000

UK (LONDON) participant 774˙369.75
7    VACCINE AND GENE THERAPY INSTITUTE OF FLORIDA CORP.

 Organization address address: SW VILLAGE PARKWAY - 3RD FLOOR 11350
city: PORT ST LUCIE FLORIDA
postcode: 34987

contact info
Titolo: Ms.
Nome: Thomas
Cognome: Mitchell
Email: send email
Telefono: 17723454797
Fax: 17723453675

US (PORT ST LUCIE FLORIDA) participant 497˙940.00
8    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Prof.
Nome: Peter G
Cognome: Kremsner
Email: send email
Telefono: 4970710000000
Fax: 497071000000

DE (TUEBINGEN) participant 490˙000.00
9 Nome Ente NON disponibile GA participant 392˙036.70
10    ISTITUTO NAZIONALE MALATTIE INFETTIVE L.SPALLANZANI - IRCCS

 Organization address address: "Via Portuense, 292"
city: ROMA
postcode: 149

contact info
Titolo: Dr.
Nome: Ramona
Cognome: Iacovino
Email: send email
Telefono: +06 55 170 976
Fax: +06 55 82 825

IT (ROMA) participant 333˙972.94
11    "College of Medicine, University of Ibadan"

 Organization address address: QUEEN ELISABETH II ROAD U.C.H.
city: Ibadan
postcode: 200001

contact info
Titolo: Prof.
Nome: Geroge
Cognome: Ademowo
Email: send email
Telefono: +234 8023 34 2856
Fax: 23422411768

NG (Ibadan) participant 300˙780.00
12    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Dr.
Nome: William Anderson
Cognome: Paxton
Email: send email
Telefono: 31205664739
Fax: 31206916531

NL (AMSTERDAM) participant 294˙800.00
13    EUROPEAN VACCINE INITIATIVE - EEIG

 Organization address address: IM NEUERHEIMER FELD 307
city: Heidelberg
postcode: 69120

contact info
Titolo: Dr.
Nome: Sten
Cognome: Larsen
Email: send email
Telefono: 4526590755
Fax: +49 6221565727

DE (Heidelberg) participant 250˙000.00
14    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mr.
Nome: Didier
Cognome: Lemoine
Email: send email
Telefono: +33 1 45 17 03 15
Fax: +33 1 48 99 54 07

FR (PARIS) participant 247˙199.70
15    Fondation international de l'Hopital de Dr. Albert Schweitzer de LAMBARENE

 Organization address address: Hopital Albert Schweitzer na
city: Lambarene
postcode: 13901

contact info
Titolo: Dr.
Nome: Saadou
Cognome: Issifou
Email: send email
Telefono: +24107457 813

GA (Lambarene) participant 218˙588.19
16    KENYA MEDICAL RESEARCH INSTITUTE

 Organization address address: Off Mbagathi Way
city: Nairobi
postcode: 200

contact info
Titolo: Dr.
Nome: Simon
Cognome: Brooker
Email: send email
Telefono: 254724000000
Fax: +254 20 2711673

KE (Nairobi) participant 213˙700.00
17    IFAKARA HEALTH INSTITUTE TRUST

 Organization address address: POBOX
city: DAR ES SALAAM

contact info
Titolo: Dr.
Nome: Barnabas
Cognome: Lugendo
Email: send email
Telefono: 255223000000
Fax: +255 232 625 312

TZ (DAR ES SALAAM) participant 205˙400.00
18    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Nicola
Cognome: Harris
Email: send email
Telefono: 410796000000
Fax: +41021 693 95 38

CH (LAUSANNE) participant 119˙480.00
19    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Michael
Cognome: Hoelscher
Email: send email
Telefono: 498922000000
Fax: 4989336038

DE (MUENCHEN) participant 106˙440.00
20    NATIONAL INSTITUTE FOR MEDICAL RESEARCH

 Organization address address: Ocean Road - Luthuli Street 2488
city: DAR ES SALAAM

contact info
Titolo: Ms.
Nome: Julius J.
Cognome: Massaga
Email: send email
Telefono: 255222000000
Fax: 255222000000

TZ (DAR ES SALAAM) participant 63˙400.00
21    EuroVacc Foundation

 Organization address city: Lausanne
postcode: 1003

contact info
Titolo: Ms.
Nome: Song
Cognome: Ding
Email: send email
Telefono: 31203149327
Fax: 31203149399

CH (Lausanne) participant 27˙400.00
22    Nome Ente NON disponibile

 Organization address address: Rue de Tolbiac 101
city: Paris
postcode: 75013

contact info
Titolo: Dr.
Nome: Véronique
Cognome: Rieux
Email: send email
Telefono: +33 1 53 94 60 15
Fax: +33 1 53 94 60 02

FR (Paris) participant 3˙600.00
23    MALARIA CONSORTIUM LBG

 Organization address address: LEONARD STREET 56-64
city: LONDON
postcode: EC2A 4LT

contact info
Titolo: Mr.
Nome: Peter
Cognome: Newton
Email: send email
Telefono: -5490370
Fax: -5490374

UK (LONDON) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

vaccines    disease    treatment    malaria    induced    patients    clinical    impact    modulation    tb    affect    data    co    vaccine    africa    african    worms    innovative    geographic    occurrence    worm    overlap    profile    idea    infections    responses    hiv    parasitic    helminth    scientists    prds    immune    innate   

 Obiettivo del progetto (Objective)

'Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.'

Introduzione (Teaser)

Nearly one in four patients with tuberculosis (TB), malaria or HIV has parasitic worm (helminth) infections. African and European scientists joined forces to elucidate how worm infections affect the immune responses.

Descrizione progetto (Article)

Moreover, there is a wide geographic overlap in occurrence between worms and HIV, TB and malaria. The EU-supported project http://www.idearesearch.eu/ (IDEA) has been studying these connections for four years.

Partners from six European and five African countries are involved in the project. The objectives of IDEA are to understand how the presence of worm infections affect immune responses specific to HIV, TB and malaria. The effects of parasitic worms on the clinical progression of these diseases are also under study.

The IDEA Central Database was established which unifies demographic, clinical and parasitological data and allows for centralised analysis. Meta-analysis of data obtained from HIV-TB- and malaria patients' cohorts from different sites is constantly underway.

Innate, or immediate immune response elicited by worm infections has been characterised. The scientists have determined whether the worm-induced innate immune response modulates the innate and adaptive immune response to HIV, TB and malaria antigens. Preliminary results were obtained regarding immunological interplay between helminth infections and HIV- and TB-specific T cell responses.

The effects of worm infections and anti-worm treatment on incidence, clinical presentation and immune responses against worms, as well as HIV, TB and malaria have been analysed. To determine the effect of worm-infections on vaccine-induced immune responses, the researchers have started vaccine trials for HIV, TB and malaria.

The IDEA research programme has made a substantial contribution to sustained and integrated research in sub-Saharan Africa. In addition, the project will ultimately contribute to the development of new successful therapies and vaccines.

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