AFFINOMICS

"Protein Binders for Characterisation of Human Proteome Function: Generation, Validation, Application"

 Coordinatore THE BABRAHAM INSTITUTE 

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Mrs.
Nome: Fang
Cognome: Gao
Email: send email
Telefono: 441223000000
Fax: 441223000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 14˙620˙568 €
 EC contributo 11˙000˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-two-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-04-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE BABRAHAM INSTITUTE

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Mrs.
Nome: Fang
Cognome: Gao
Email: send email
Telefono: 441223000000
Fax: 441223000000

UK (CAMBRIDGE) coordinator 823˙536.00
2    KUNGLIGA TEKNISKA HOEGSKOLAN

 Organization address address: Valhallavaegen 79
city: STOCKHOLM
postcode: 10044

contact info
Titolo: Mr.
Nome: Eriksson
Cognome: åke
Email: send email
Telefono: +46 8 5537 8288
Fax: +46 8 5537 8056

SE (STOCKHOLM) participant 1˙909˙515.00
3    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Andreas
Cognome: Plückthun
Email: send email
Telefono: +41 44 635 55 70

CH (ZURICH) participant 1˙125˙484.00
4 KOBENHAVNS UNIVERSITET DK participant 727˙600.00
5    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Prof.
Nome: Carl
Cognome: Borrebaeck
Email: send email
Telefono: +46 46 2229613
Fax: +46 46 2224200

SE (LUND) participant 695˙742.00
6    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Ms.
Nome: Margareta
Cognome: Uvhagen Antoni
Email: send email
Telefono: 46184716312
Fax: 46184711982

SE (UPPSALA) participant 670˙293.00
7    TECHNISCHE UNIVERSITAT BRAUNSCHWEIG

 Organization address address: POCKELSSTRASSE 14
city: BRAUNSCHWEIG
postcode: 38106

contact info
Titolo: Prof.
Nome: Stefan
Cognome: Dübel
Email: send email
Telefono: +49 531 391 5731
Fax: +49 531 391 5763

DE (BRAUNSCHWEIG) participant 565˙664.00
8    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Ms.
Nome: Bettina
Cognome: Crispin
Email: send email
Telefono: +49 6221 42 2700
Fax: +49 6221 42 2708

DE (HEIDELBERG) participant 540˙358.00
9    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: +32 9 244 66 11
Fax: +32 9 244 66 10

BE (ZWIJNAARDE - GENT) participant 505˙473.00
10    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Jaana
Cognome: Heino
Email: send email
Telefono: +358 20 722 3301
Fax: +358 20 722 3499

FI (ESPOO) participant 459˙007.00
11    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Ms.
Nome: Barbara
Cognome: Baron
Email: send email
Telefono: +44 1223 492520
Fax: +44 1223 494470

DE (HEIDELBERG) participant 454˙400.00
12    UNIVERSITAET KASSEL

 Organization address address: MONCHEBERGSTRASSE 19
city: KASSEL
postcode: 34125

contact info
Titolo: Prof.
Nome: Friedrich
Cognome: Herberg
Email: send email
Telefono: +49 561 804 4511
Fax: +49 561 804 4466

DE (KASSEL) participant 426˙579.00
13    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA

 Organization address address: VIA ORAZIO RAIMONDO 18
city: ROMA
postcode: 173

contact info
Titolo: Prof.
Nome: Gianni
Cognome: Cesareni
Email: send email
Telefono: +39 06 72594315
Fax: +39 06 2023500

IT (ROMA) participant 398˙282.00
14    PARATOPES LIMITED

 Organization address address: WOODFALL AVENUE 62 BARNET
city: LONDON
postcode: EN5 2HA

contact info
Titolo: Mr.
Nome: Alan
Cognome: Sawyer
Email: send email
Telefono: 447513000000

UK (LONDON) participant 390˙284.00
15    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Nome: Christine
Cognome: Augustin
Email: send email
Telefono: +49 7071 2984846
Fax: +49 7071 295777

DE (TUEBINGEN) participant 374˙014.00
16    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Dr.
Nome: Miles
Cognome: Davies
Email: send email
Telefono: 46852486593
Fax: 468310343

SE (STOCKHOLM) participant 290˙763.00
17    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Dr.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

UK (OXFORD) participant 290˙763.00
18    BABRAHAM BIOSCIENCE TECHNOLOGIES LIMITED

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Ms.
Nome: Rebecca
Cognome: Paxton
Email: send email
Telefono: 441223000000
Fax: 441223000000

UK (CAMBRIDGE) participant 220˙672.00
19    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Jürgen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022
Fax: +49 89 3187 3866

DE (MUENCHEN) participant 131˙571.00
20    The Structural Genomics Consortium

 Organization address address: Euston Road 215
city: London
postcode: NW1 2BE

contact info
Titolo: Dr.
Nome: Susanne
Cognome: Muller-Knapp
Email: send email
Telefono: +44 1865 617587
Fax: +44 1865 617575

UK (London) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

characterisation    human    functional    throughput    affinity    reagents    proteins    proteome    recombinant    cancer    cell    binders    binder    fragments    affinomics    antibodies    protein    quality    antigens    complexes   

 Obiettivo del progetto (Objective)

'The Affinomics programme aims to leverage existing efforts in Europe to generate large-scale resources of validated protein-binding molecules (‘binders’) as affinity reagents for characterisation of the human proteome and to apply them in comprehensive structural and functional analyses of protein expression, interactions and complexes. Proteome targets will be focused on five categories of inter-related human proteins involved in signal transduction, cell regulation and cancer, namely protein kinases, SH2 domain-containing proteins, protein tyrosine phosphatases, proteins somatically mutated in cancers and candidate cancer biomarkers. Binders to about 1000 protein targets will be made over the course of the programme. A high throughput, coordinated production pipeline for antigens and binders will be established. Target antigens will be expressed in three forms, as folded full-length proteins or domains, as large peptide fragments (PrESTs) based on low homology to other human proteins and as small peptides, in some cases phosphorylated. Binder types to be generated include affinity-purified polyclonal antibodies, monoclonal antibodies, recombinant antibody fragments and non-immunoglobulin scaffolds. An important aspect will be the development of highly efficient ‘next generation’ recombinant selection methods, based on phage, cell and ribosome display, capable of producing high quality binders at greater throughput and lower cost than hitherto. Systems and procedures for thorough binder validation and quality control will be established. The affinity reagents will be applied in advanced innovative and sensitive technologies for specific detection of target proteins and interacting protein complexes in cells, tissues and fluids, for improved understanding of protein function and new classes of diagnostic assays.'

Introduzione (Teaser)

European researchers are building a database of functional proteins and their specific binders. With widespread applications in characterisation of the human proteome, biotech and biomedicine, the scope of the AFFINOMICS project is enormous.

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