NANOMECH

Protein Friction of Molecular Machines: Nanomechanics with Optical Tweezers

Coordinatore	EBERHARD KARLS UNIVERSITAET TUEBINGEN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙500˙000 €
EC contributo	1˙500˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-12-01   -   2015-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET DRESDEN  Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 contact info Titolo: Ms. Nome: Friederieke Cognome: Noack Email: send email Telefono: +49 351 463 42191 Fax: +49 351 463 39742	DE (DRESDEN)	beneficiary	824˙235.80
2	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Dr. Nome: Erik Cognome: Schäffer Email: send email Telefono: +49 7071 2978831 Fax: +49 7071 295042	DE (TUEBINGEN)	hostInstitution	675˙764.20
3	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Mrs. Nome: Elisabeth Cognome: Baier Email: send email Telefono: +49 7071 29 78760 Fax: +49 7071 295990	DE (TUEBINGEN)	hostInstitution	675˙764.20

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 Obiettivo del progetto (Objective)

'Molecular machines---assemblies of macromolecules, often fueled by nucleotide hydrolysis---are fascinating devices and crucial for driving self-organization in cells. While protein components of many biological machines have been identified, and in many cases their structures have been solved, the mechanical principles that govern the operation of biological machines are poorly understood. For example, how much force can they generate; and what limits their speed and efficiency? These questions have been difficult to answer because the tools needed to study nanometer-sized machines that generate minute forces on the order of piconewtons have not been available until recently. Friction arises between proteins when they interact by making and breaking weak intermolecular bonds. When a bond breaks, the energy stored in its deformation is dissipated. Protein friction is a useful concept because it provides mechanical insight and allows for quantitative theoretical understanding of the dynamics and energy balance of mechanical cellular processes. In cells, many motor proteins often cooperate to drive motility. I will ask how friction and force-generation arise and scale with the number of motors to elucidate how collective behavior and self-organization emerge. The goals of this interdisciplinary project address the role that protein friction plays in limiting the dynamics and efficiency of microtubule-based motor proteins using a novel, combined optical tweezers and single-molecule fluorescence apparatus. In the long term, I hope that our avant-garde nanotechnological tools will be applicable to other molecular machines and that the studies on microtubule-based motors will shed light on the way that cells use energy to create pattern and order.'