IMMEEDIA

Immunomodulatory Effects of Exercise in Type 1 Diabetes

 Coordinatore UNIVERSITA DEGLI STUDI DI MILANO 

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Ms.
Nome: Daniela
Cognome: Pozzi
Email: send email
Telefono: +39 02 50315151
Fax: +39 02 50315383

 Nazionalità Coordinatore Italy [IT]
 Totale costo 583˙200 €
 EC contributo 399˙600 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IRSES
 Funding Scheme MC-IRSES
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2014-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Ms.
Nome: Daniela
Cognome: Pozzi
Email: send email
Telefono: +39 02 50315151
Fax: +39 02 50315383

IT (MILANO) coordinator 194˙400.00
2    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Tommy
Cognome: Spångö
Email: send email
Telefono: +46 8 517 73122
Fax: +46 8 517 76900

SE (STOCKHOLM) participant 86˙400.00
3    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

 Organization address address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908

contact info
Titolo: Ms.
Nome: Victoria
Cognome: Cochrane
Email: send email
Telefono: +34 932607226
Fax: 34932607224

ES (L'HOSPITALET DE LLOBREGAT) participant 64˙800.00
4    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Titolo: Mr.
Nome: Mario
Cognome: Valsecchi
Email: send email
Telefono: +39 02 26432729
Fax: +39 02 26432752

IT (MILANO) participant 54˙000.00
5    Ospedale San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: 390226000000
Fax: 390226000000

IT (Milano) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    autoimmune    moderate    loss    subjects    diseases    disease    protective    blood    worsening    oxidative    producing    modulation    dysfunction    diabetes    beta    immunomodulatory    insulin    prevention    prevent    dm    reducing    regular    toxicity    function    inflammation    onset    exercise    physical    islets    cells    diabetic    sensitivity    stress    chronic    sugar    administration    levels    patients    effect    metabolic    besides       outcomes    training    immune    pancreas   

 Obiettivo del progetto (Objective)

'Diabetes is a major metabolic disease with huge costs for healthcare system throughout the EU and worldwide. Type 1 Diabetes (T1DM) is a chronic condition in which pancreas produces little or no insulin, believed to result from a disorder of immunoregulation. For decades it has been known that regular aerobic exercise improves insulin sensitivity in diabetic patients, reducing insulin requirements. Traditionally, physical exercise has been promoted in type 2 diabetes, where insulin action is deficient in the context of insulin resistance and/or inappropriate insulin secretion. However, even in T1DM, in the dysregulation of immune system function, beta-cell toxicity is mediated by a complex interplay between oxidative stress and inflammation, for which exercise could be protective. Preliminary observations in fact indicate that regularly exercising T1DM-subjects have lower autoimmunity markers at an early stage of the disease. We want to ascertain the effect of moderate regular exercise as the most convenient measure to avoid the onset/worsening of T1DM. To verify whether exercise is capable of countering the T1DM-autoimmune process directed against beta-cells of the pancreatic islets, a multi-centric study will include: a) administration of a tailored exercise training program in different cohorts of T1DM-subjects; b) in-vivo animal experiments in which gain/loss-function models will be challenged with exercise; c) cell studies to analyse the exercise effects on signal transduction pathways and cytokine responses; d) metabolic profiling and metabolomic studies concerning the multicomponent analysis of biological fluids, tissue and cell extracts. Our consortium, through this multi-approach strategy, will reveal how exercise may exert a potent immunomodulatory effect, reducing the autoimmune response that in T1DM attacks and destroys the insulin producing cells.'

Introduzione (Teaser)

Diabetes mellitus, whether type 1 (T1DM) or type 2, is a disease characterised by uncontrolled blood sugar levels due to inadequate insulin production. EU researchers determined how physical activity is beneficial.

Descrizione progetto (Article)

Dysfunction or destruction of insulin-producing beta cells in the pancreas is the main cause for diabetes. Research has indicated that regular and moderate exercise could prevent the onset or worsening of diabetes, an autoimmune condition.

The project IMMEEDIA (Immunomodulatory effects of exercise in type 1 diabetes) was initiated to comprehensively investigate the benefits of exercise for symptom reduction or prevention of T1DM onset. Researchers conducted a large-scale multi-approach study to identify genetic and epigenetic factors predisposing to diabetes as well as suitable biomarkers.

Beta cells are present in the islets of Langerhans in the pancreas. In T1DM patients, beta cell toxicity has been associated with oxidative stress and inflammation as a result of immune system dysfunction. Therefore, testing was done on patients who underwent islet transplantation.

Results revealed that administration of a tailored exercise training programme significantly reduced loss of beta cell function through increased insulin sensitivity that in turn lowers blood sugar levels. Moreover, better immune regulation was apparent.

Studies on non-obese diabetic mice were conducted to gauge the effects of moderate-intensity exercise on the immune system and beta cell function. Results were highly promising, showing improved metabolic capacity and immune modulation.

Project outcomes have provided an evidence-based foundation for using physical exercise as a means to alleviate or prevent diabetes. The results show that exercise is a cornerstone in the prevention, cure and treatment of all-species metabolic disturbances. Besides being cheap and physiological, the risks of over-indulging in exercise are minimal.

Successful demonstration of the protective effects of exercise on immune modulation could also be used to treat other autoimmune diseases such as lupus and rheumatoid arthritis. Besides identifying populations at risk of developing chronic diseases like diabetes, study outcomes could be used to identify interventions that reduce the ensuing socioeconomic burden.

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