HARP

Evaluation and impact of screening and treatment approaches for the prevention of cervical neoplasia in HIV-positive women in Burkina Faso and South Africa: HPV in Africa Research Partnership

Coordinatore	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE    more  Organization address address: KEPPEL STREET city: LONDON postcode: WC1E7HT contact info Titolo: Mr. Nome: Frankie Cognome: Liew Email: send email Telefono: 442080000000 Fax: 442074000000
Nazionalità Coordinatore	United Kingdom [UK]
Sito del progetto	http://www.harp-fp7.org
Totale costo	3˙919˙769 €
EC contributo	3˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-AFRICA-2010
Funding Scheme	CP-FP-SICA
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01   -   2014-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE  Organization address address: KEPPEL STREET city: LONDON postcode: WC1E7HT contact info Titolo: Mr. Nome: Frankie Cognome: Liew Email: send email Telefono: 442080000000 Fax: 442074000000	UK (LONDON)	coordinator	694˙994.00
2	UNIVERSITY OF THE WITWATERSRAND JOHANNESBURG  Organization address address: JAN SMUTS AVENUE 1 city: JOHANNESBURG postcode: 2001 contact info Titolo: Ms. Nome: Violet Cognome: Parker Email: send email Telefono: 27112749273 Fax: 27112749273	ZA (JOHANNESBURG)	participant	1˙237˙360.00
3	CENTRE DE RECHERCHE INTERNATIONALE POUR LA SANTE  Organization address address: Avenue de l'Universite 221 Secteur 13 Zogona city: Ouagadougou postcode: 9 contact info Titolo: Ms. Nome: Aminata Cognome: Karambiri Email: send email Telefono: 22650308257 Fax: 22650308258	BF (Ouagadougou)	participant	621˙201.00
4	UNIVERSITE MONTPELLIER I  Organization address address: BOULEVARD HENRI IV 5 city: MONTPELLIER postcode: 34967 contact info Titolo: Ms. Nome: Cara Chan Cognome: Manville Email: send email Telefono: 33467548596 Fax: 33467548597	FR (MONTPELLIER)	participant	446˙445.00

Mappa

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 Obiettivo del progetto (Objective)

'The proposal's overall aim is to improve cervical cancer prevention programs for HIV–infected women in Africa, by evaluating the effectiveness and cost-effectiveness of alternative screening strategies, and by developing algorithms leading to earlier detection and management of cervical cancer in these high-risk populations.

The proposal's hypotheses are that: i) the use of simplified point of care diagnostic tests to detect high-risk (HR) HPV DNA , never before evaluated in Africa, alone or combination with other tests in various triage strategies has the potential to improve the coverage of cervical cancer screening in high-risk populations, and that it will prove a cost-effective cervical cancer prevention intervention in the long term; and ii) immune restoration and control of HIV replication through highly active antiretroviral therapy (HAART) or HAART initiation improves clearance of HPV infection among high-risk (HR)-HPV infected women, therefore slowing the development or progression of cervical precursor lesions. These findings may suggest that varying strategies or frequencies of screening may be required for women on HAART or not.

The study will enroll 1200 HIV positive women (half on HAART or about to start HAART; and half with high CD4 count>350) in Burkina Faso and South Africa in a cross-sectional evaluation of cervical cancer screening strategies, from which about 1100 HIV-infected women without CIN2 will be followed at one year to detect incident CIN2 and persistence, incidence and clearance of HR HPV. A costing and modelling studies will determine the cost-effectiveness of triage strategies targeting HIV women.'

Introduzione (Teaser)

HIV-infected women in Africa are vulnerable to other health problems. An EU-funded project aims to help guide cervical cancer screening programmes.