MODHEP

Systems biology of liver cancer: an integrative genomic-epigenomic approach

 Coordinatore FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

 Organization address address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
Titolo: Ms.
Nome: Giulia
Cognome: Campodonico
Email: send email
Telefono: +39 010 71781 737
Fax: +39 010 72 0321

 Nazionalità Coordinatore Italy [IT]
 Totale costo 16˙861˙941 €
 EC contributo 11˙936˙899 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2010-two-stage
 Funding Scheme CP-IP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-01-01   -   2016-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

 Organization address address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
Titolo: Ms.
Nome: Giulia
Cognome: Campodonico
Email: send email
Telefono: +39 010 71781 737
Fax: +39 010 72 0321

IT (GENOVA) coordinator 687˙841.70
2    ISTITUTO EUROPEO DI ONCOLOGIA SRL

 Organization address address: Via Filodrammatici 10
city: MILANO
postcode: 20121

contact info
Titolo: Ms.
Nome: Ilaria
Cognome: Foti
Email: send email
Telefono: 390257000000
Fax: 390294000000

IT (MILANO) participant 1˙762˙573.32
3    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Ms.
Nome: Corinne
Cognome: Cumin
Email: send email
Telefono: +33 1 56 24 66 20
Fax: +33 1 56 24 66 27

FR (PARIS) participant 1˙362˙500.00
4    RIKEN THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH

 Organization address address: HIROSAWA 2-1
city: WAKO SHI SAITAMA
postcode: 351 0198

contact info
Titolo: Mr.
Nome: Haruo
Cognome: Yamaguchi
Email: send email
Telefono: +81 48 467 9299
Fax: +81 48 467 2634

JP (WAKO SHI SAITAMA) participant 951˙000.00
5    FONDAZIONE TELETHON

 Organization address address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
Titolo: Dr.
Nome: Irene
Cognome: Mearelli
Email: send email
Telefono: +39 06 44015308
Fax: +39 06 44119224

IT (ROMA) participant 825˙230.99
6    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Titolo: Mr.
Nome: Don
Cognome: Van Velzen
Email: send email
Telefono: +31 30 212 1800
Fax: +31 30 2121865

NL (AMSTERDAM) participant 805˙000.00
7    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 140613378
Fax: +33 140613940

FR (PARIS CEDEX 15) participant 800˙000.00
8    THE BABRAHAM INSTITUTE

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Dr.
Nome: Caroline
Cognome: Edmonds
Email: send email
Telefono: +44 1223 496 207
Fax: +441223 496 002

UK (CAMBRIDGE) participant 797˙486.00
9    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Annick
Cognome: Salini
Email: send email
Telefono: 33149595360
Fax: 33149595361

FR (PARIS) participant 760˙004.00
10    WEIZMANN INSTITUTE OF SCIENCE

 Organization address address: HERZL STREET 234
city: REHOVOT
postcode: 7610001

contact info
Titolo: Ms.
Nome: Talia
Cognome: Tzahor
Email: send email
Telefono: +972 8 934 4026
Fax: +972 8934 4165

IL (REHOVOT) participant 647˙999.00
11    MATER MEDICAL RESEARCH INSTITUTE LIMITED

 Organization address address: LEVEL 3 AUBIGNY PLACE
city: SOUTH BRISBANE

contact info
Titolo: Mr.
Nome: Ian
Cognome: Allan
Email: send email
Telefono: +61073163 3416
Fax: +61073163 2550

AU (SOUTH BRISBANE) participant 577˙570.00
12    FONDAZIONE SANTA LUCIA

 Organization address address: VIA ARDEATINA 306
city: Roma
postcode: 179

contact info
Titolo: Dr.
Nome: Antonio
Cognome: Lerna
Email: send email
Telefono: +39 0651501504
Fax: +39 0651501408

IT (Roma) participant 574˙148.00
13    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Isobel
Cognome: Blair
Email: send email
Telefono: +44 131 527 4453
Fax: +44 131 440 0434

UK (EDINBURGH) participant 493˙177.00
14    BIOBYTE SOLUTIONS GMBH

 Organization address address: Bothestrasse 142
city: Heidelberg
postcode: 69126

contact info
Titolo: Dr.
Nome: Ivica
Cognome: Letunic
Email: send email
Telefono: +49 6221 387 8534
Fax: +49 6221 430 8658

DE (Heidelberg) participant 318˙600.00
15    ACIES Consulting Group SAS

 Organization address city: LYON
postcode: 69002

contact info
Titolo: Mrs.
Nome: Elise
Cognome: Castan
Email: send email
Telefono: +33 478924000
Fax: +33 478924001

FR (LYON) participant 295˙569.99
16    NOVAMEN SAS

 Organization address city: LYON
postcode: 69002

contact info
Titolo: Mrs.
Nome: Elise
Cognome: Castan
Email: send email
Telefono: +33 478924000
Fax: +33 478924001

FR (LYON) participant 167˙210.01
17    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Mr.
Nome: Paul
Cognome: Labbett
Email: send email
Telefono: 442078000000
Fax: 442078000000

UK (LONDON) participant 99˙085.00
18    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Kate
Cognome: Wilson
Email: send email
Telefono: +44 131 332 2471
Fax: +44 131 467 8456

UK (SWINDON) participant 11˙903.99

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

preneoplastic    stage    mutations    events    genetic    stages    tumors    liver    alterations    cancer    multiple    involving    epigenetic    disease   

 Obiettivo del progetto (Objective)

'Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplastic phases to overt cancer. Until now, no systematic effort has been undertaken to investigate these multiple layers of genome organization and function during cancer development. MODHEP aims at providing a 360° understanding of liver cancer, one of the most common types of tumors and, because of the homogeneity of the hepatic tissue, the most experimentally tractable one. The consortium brings together elite European scientists in the fields of genetics, chromatin regulation, genomics, liver cancer, computational and systems biology. This combination of skills will allow us to investigate and model at unprecedented resolution the chain of events leading from environmental perturbations and the occurrence of driver mutations to preneoplastic disease and cancer. Our experimental plan reflects some grounded assumptions: 1. cancer cannot be modeled without detailed information on the preneoplastic stages of disease; 2. genetic heterogeneity in humans would make systems-level modeling non realistic from a practical point of view. Both of these limitations are bypassed by the use of well-defined mouse models, followed by evaluation of the main conclusions in clinical samples; 3. many early stage driving events in cancer represent epigenetic alterations, which are invisible to classical genetic analysis, and are confounded by secondary and tertiary events in established tumors. Our approach will enable the identification of therapeutically relevant early-stage genetic and epigenetic alterations and the definition of their interplay in tumor development and maintenance.'

Introduzione (Teaser)

Cancer is a complex disease involving multiple genetic and epigenetic events in different stages. An EU-funded project is studying the onset and development of liver cancer for facilitating effective anti-cancer therapy.

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