EPC-TM-NET

Targeting the tumour microenvironment to improve pancreatic cancer prognosis

 Coordinatore PHILIPPS UNIVERSITAET MARBURG 

 Organization address address: Biegenstrasse 10
city: MARBURG
postcode: 35032

contact info
Titolo: Ms.
Nome: Sandra
Cognome: Basenau
Email: send email
Telefono: +49 6421 28 26938
Fax: +49 6421 28 27021

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://epcnet.eu/
 Totale costo 4˙230˙298 €
 EC contributo 3˙000˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2010-two-stage
 Funding Scheme CP-FP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-02-01   -   2014-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    PHILIPPS UNIVERSITAET MARBURG

 Organization address address: Biegenstrasse 10
city: MARBURG
postcode: 35032

contact info
Titolo: Ms.
Nome: Sandra
Cognome: Basenau
Email: send email
Telefono: +49 6421 28 26938
Fax: +49 6421 28 27021

DE (MARBURG) coordinator 626˙777.00
2    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Ms.
Nome: Laura
Cognome: Bertolini
Email: send email
Telefono: +34 917 328 000
Fax: +34 9 12246980

ES (MADRID) participant 550˙000.00
3    Nome Ente NON disponibile

 Organization address address: Domstrasse 11
city: GREIFSWALD
postcode: 17487

contact info
Titolo: Dr.
Nome: Andrea
Cognome: Völker
Email: send email
Telefono: +49 3834 865097
Fax: +49 3834 865098

DE (GREIFSWALD) participant 270˙000.00
4    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Ms.
Nome: Veronica
Cognome: Shaw
Email: send email
Telefono: +44 151 794 8722
Fax: +44 151 794 8728

UK (LIVERPOOL) participant 248˙800.00
5    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Rolf
Cognome: Trana
Email: send email
Telefono: 46852487741
Fax: 46858582224

SE (STOCKHOLM) participant 207˙560.00
6 Concentris Research Management GmbH DE participant 202˙838.00
7    UNIVERSITA DEGLI STUDI DI VERONA

 Organization address address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129

contact info
Titolo: Dr.
Nome: Enrico
Cognome: Cazzaroli
Email: send email
Telefono: +39 045 8126446
Fax: +39 045 8127432

IT (VERONA) participant 145˙000.00
8    CANCER RESEARCH UK

 Organization address address: ST JOHN STREET 407 ANGEL BUILDING
city: LONDON
postcode: EC1V 4AD

contact info
Titolo: Dr.
Nome: Emma
Cognome: Ryley
Email: send email
Telefono: +44 1223 404262
Fax: +44 1223 404199

UK (LONDON) participant 144˙365.00
9    TECHNISCHE UNIVERSITAET MUENCHEN

 Organization address address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333

contact info
Titolo: Ms.
Nome: Katrin
Cognome: Hörmann
Email: send email
Telefono: +49 89 289 22629
Fax: +49 89 289 22620

DE (MUENCHEN) participant 138˙600.00
10    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

 Organization address address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675

contact info
Titolo: Ms.
Nome: Beate
Cognome: Schaulin
Email: send email
Telefono: +49 89 4140 2856
Fax: +49 89 4140 4926

DE (MUENCHEN) participant 131˙400.00
11    Bayer Pharma AG

 Organization address address: Muellerstrasse 178
city: Berlin
postcode: 13353

contact info
Titolo: Mrs.
Nome: Delia
Cognome: Nölte
Email: send email
Telefono: +49 30 468 12351

DE (Berlin) participant 76˙462.00
12    Axcentua Pharmaceuticals AB

 Organization address address: Alfred Nobels Alle 10
city: Huddinge
postcode: 14152

contact info
Titolo: Dr.
Nome: Michael-Robin
Cognome: Witt
Email: send email
Telefono: +46 0 705086413

SE (Huddinge) participant 72˙440.00
13    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Nome: Mario
Cognome: Valsecchi
Email: send email
Telefono: +39 02 2643 2729
Fax: +39 02 2643 2752

IT (MILANO) participant 60˙000.00
14    UNIVERSITA DEGLI STUDI DI TORINO

 Organization address address: Via Giuseppe Verdi 8
city: TORINO
postcode: 10124

contact info
Titolo: Mr.
Nome: Antonio
Cognome: Baldassarre
Email: send email
Telefono: +39 0116705304
Fax: +39 0116705310

IT (TORINO) participant 60˙000.00
15    NATIMAB THERAPEUTICS SRL

 Organization address address: VIA RIBES 5
city: COLLERETTO GIACOSA TORINO
postcode: 10010

contact info
Titolo: Prof.
Nome: Gianni
Cognome: Garotta
Email: send email
Telefono: +41 79 4581266
Fax: +39 0125 538791

IT (COLLERETTO GIACOSA TORINO) participant 45˙000.00
16    LAB 21 LIMITED

 Organization address address: Cambridge Science Park 184
city: Cambridge
postcode: CB4 0GA

contact info
Titolo: Dr.
Nome: Anthony
Cognome: Cooke
Email: send email
Telefono: +44 0 1223 395463
Fax: +44 0 1223 395451

UK (Cambridge) participant 20˙758.00
17    Fondazione Centro San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 2643 4717

IT (Milano) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

survival    drug    disease    groups    tumour    scientists    therapeutic    human    pancreatic    models    resistance    oncology    clinical    cells    innovative    pancreas    mouse    carcinogenesis    microenvironment    chemotherapeutic    cancer   

 Obiettivo del progetto (Objective)

'Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased risk for pancreatic cancer indicate, that the tumour microenvironment is of particular importance for carcinogenesis in the pancreas. The long-term objective of this proposal is to increase survival of pancreatic cancer patients by exploring the contribution of the tumour microenvironment to the failure of presently available oncological treatments. For this purpose the clinical observation will be reverse-translated into innovative in-vitro and mouse models closely mimicking the human disease. This will allow a profound study of the mechanistic basis of treatment failure by deciphering the complex network between components of the microenvironment and cancer cells leading to increased resistance to chemotherapy and infiltrative growth along adjacent lymphatic and neural structures as well as metastatic spread. Identification of cancer (stem) cell-autonomous as well as stromal-derived mediators of invasion and chemoresistance will lead to novel drug targets to overcome the current therapeutic dilemma. The consortium has been specifically designed to include all required levels of expertise: 1) surgical and medical oncology groups conducting the largest clinical trials for pancreatic cancer in Europe, 2) expert pancreatic pathologists, 3) basic scientists focused on the study of carcinogenesis and tumour microenvironment interactions in the pancreas, 4) molecular oncology groups that have developed genetically engineered mouse models faithfully recapitulating human pancreatic cancer, as well as 5) pharmaceutical industry specialised on drug development.'

Introduzione (Teaser)

The role of the microenvironment in tumour progression is prompting scientists to develop innovative therapeutic solutions that target the tumour stroma. This approach is expected to abolish the growth advantage of tumour cells and facilitate the accessibility of chemotherapeutic agents.

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