OPTIMUNISE

Optimising the impact and cost-effectiveness of child health intervention programmes of vaccines and micronutrients in low-income countries

Coordinatore	STATENS SERUM INSTITUT    more  Organization address address: ARTILLERIVEJ 5 city: KOBENHAVN S postcode: 2300 contact info Titolo: Mr. Nome: Torben Cognome: Theilmann Email: send email Telefono: +45 32683614 Fax: +45 32683165
Nazionalità Coordinatore	Denmark [DK]
Totale costo	3˙978˙640 €
EC contributo	2˙999˙970 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2010-single-stage
Funding Scheme	CP-FP-SICA
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-03-01   -   2016-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STATENS SERUM INSTITUT  Organization address address: ARTILLERIVEJ 5 city: KOBENHAVN S postcode: 2300 contact info Titolo: Mr. Nome: Torben Cognome: Theilmann Email: send email Telefono: +45 32683614 Fax: +45 32683165	DK (KOBENHAVN S)	coordinator	347˙280.00
2	INSTITUTO NACIONAL DE SAUDE PUBLICA  Organization address address: Av. Combatente da Liberdade da Patria 100 city: Bissau Codex postcode: 1004 contact info Titolo: Mrs. Nome: Amabelia Cognome: Rodrigues Email: send email Telefono: +245 6681782	GW (Bissau Codex)	participant	929˙390.00
3	CENTRE DE RECHERCHE EN SANTE DE NOUNA  Organization address address: BP 02 city: NOUNA postcode: 13 contact info Titolo: Dr. Nome: Ali Cognome: Sie Email: send email Telefono: +226 20537043 Fax: +226 20537055	BF (NOUNA)	participant	928˙400.00
4	GHANA HEALTH SERVICE  Organization address address: CATHERDRAL SQUARE ADABRAKA city: ACCRA contact info Titolo: Dr. Nome: Abraham Cognome: Hodgson Email: send email Telefono: +233 742 22310 Fax: 23374222320	GH (ACCRA)	participant	495˙300.00
5	UNIVERSITAETSKLINIKUM HEIDELBERG  Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 contact info Titolo: Ms. Nome: Maria Cognome: Schmitt Email: send email Telefono: +49 6221 562428 Fax: +49 6221 565460	DE (HEIDELBERG)	participant	215˙000.00
6	RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN  Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA contact info Titolo: Mr. Nome: Rob Cognome: Riesmeijer Email: send email Telefono: 31202743886	NL (BILTHOVEN)	participant	45˙000.00
7	INDEPTH NETWORK  Organization address address: "Mensah Wood Street, East Legon 11" city: ACCRA postcode: KD contact info Titolo: Dr. Nome: Osman Cognome: Sankoh Email: send email Telefono: 233303000000 Fax: 233303000000	GH (ACCRA)	participant	39˙600.00
8	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Dr. Nome: Katie Louise Cognome: Flanagan Email: send email Telefono: +220 44954426 Fax: +220 4497952	UK (SWINDON)	participant	0.00

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 Obiettivo del progetto (Objective)

'International child health programmes in low-income countries are justified in term of their impact on child survival. However, the effect estimates are usually calculated from performance indicators and assumptions about efficacy based on small-scale target-specific studies. There is little follow-up of how the programmes are implemented in real life.

This approach is clearly not sufficient. Recent studies have consistently shown that vaccines and micronutrients have non-specific effects, i.e. effects which are not explained by prevention of the targeted infections or deficiencies. These effects are often sex-differential. Furthermore, interventions may interact. Hence, the overall impact of child health programs can not be extrapolated from small-scale target-specific studies. There is a need to assess the real life impact and cost-effectiveness of child health intervention programmes in the context where they are being used.

We propose to use health and demographic surveillance system (HDSS) sites in Africa to register information routinely on all interventions in childhood, such as all vaccinations, micronutrient supplementation, and de-worming, given at health centres or in campaigns. Using this information we will measure the overall health impact of the child health programs.

The HDSS platform can also be used for testing modifications of the current health programmes. We will test a recent finding from a randomised trial in Guinea-Bissau: providing early measles vaccine at 4.5 and 9 months of age compared with the recommended measles vaccine at age 9 months reduced overall mortality from 4.5 to 36 months of age by astonishing 49%.

The HDSS sites already collect data on mortality, and mortality would be the main outcome, but we also aim to identify other relevant comparable outcome parameters which correlate with mortality and which can be used to assess the overall impact of existing and new interventions.'