FRZDMD

Contribution of calcium-independent isoforms of phospholipase A2 in the pathogenesis of Duchenne muscular dystrophy

 Coordinatore UNIVERSITE DE GENEVE 

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Laurent
Cognome: Bernheim
Email: send email
Telefono: +41 22 379 53 92

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 187˙028 €
 EC contributo 187˙028 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2010-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-06-01   -   2014-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Laurent
Cognome: Bernheim
Email: send email
Telefono: +41 22 379 53 92

CH (GENEVE) coordinator 187˙028.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

skeletal    isoforms    entry    absence    determine    mutations    muscle    fibers    cytosolic    applicant    prof    death    cell    dmd    mdx    patients    muscular    dystrophin    affected    bernheim    disease    calcium    ipla   

 Obiettivo del progetto (Objective)

'The applicant proposes a 2-year project to be performed under the supervision of Prof Bernheim, a neuromuscular disease expert at the University of Geneva. The goal of this project is to determine the role of isoforms of calcium-independent isoform phospholipase A2 (iPLA2) in cytosolic calcium entry and muscle cell death during Duchenne muscular dystrophy (DMD). DMD is the most severe case of muscle-wasting diseases of the muscular dystrophies family. It affects 1 in 3500 children, and is caused by mutations in dystrophin mRNA leading to the absence of the protein in skeletal muscles from affected patients. As dystrophin is an important player in muscle maintenance, its absence leads to skeletal muscle degeneration. To date, this is an incurable disease with 100% of fatality. Affected boys first lose the ability to walk, then breath, and finally die before being 30 years old. Although many mutations have been characterized, more research is needed to understand the molecular and signaling mechanisms underlying DMD, and increase the opportunities to find new therapeutic targets. Recent experiments have highlighted the importance of calcium entry in muscle fibers death. iPLA2 appears to have a role in this elevated cytosolic calcium, and has been shown to be upregulated both in DMD patients and dystrophic mdx mice. The applicant will 1) establish the implication and roles of the different iPLA2 isoforms in DMD by comparing calcium responses and muscle cell-death in wild-type (wt) and mdx muscle fibers, and 2) determine the effects of specific inhibitors on muscle cell survival. This project could have beneficial issues towards developing new strategies to counteract cytosolic calcium imbalance in muscle fibers from DMD patients, and thus potentially alleviate their symptoms. The applicant will benefit from the expertise of Prof Bernheim and the knowledge she previously acquired abroad to conduct this research project, and later pursue a research and teaching career in Europe.'

Altri progetti dello stesso programma (FP7-PEOPLE)

EUVIRNA (2011)

European Training Network on (+)RNA Virus Replication and Antiviral Drug Development

Read More  

MMIP (2012)

Movement and Migration in Irish Prehistory

Read More  

MC VACUOLE (2012)

Trafficking to the Vacuoles in Plants

Read More