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PHOCNOSIS SIGNED

Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PHOCNOSIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT POLITECNICA DE VALENCIA 

Organization address
address: CAMINO DE VERA SN EDIFICIO 3A
city: VALENCIA
postcode: 46022
website: www.upv.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://web.archive.org/web/20180412122207/https://phocnosis.eu/
 Total cost 4˙146˙163 €
 EC max contribution 3˙593˙962 € (87%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT POLITECNICA DE VALENCIA ES (VALENCIA) coordinator 1˙097˙891.00
2    UNIVERSITEIT TWENTE NL (ENSCHEDE) participant 423˙731.00
3    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 409˙050.00
4    AALBORG UNIVERSITET DK (AALBORG) participant 344˙915.00
5    CDA GMBH DE (SUHL OT ALBRECHTS) participant 336˙537.00
6    ST GEORGE'S HOSPITAL MEDICAL SCHOOL UK (LONDON) participant 315˙937.00
7    EV GROUP E. THALLNER GMBH AT (ST FLORIAN AM INN) participant 257˙650.00
8    BIONOS BIOTECH SL ES (VALENCIA) participant 227˙000.00
9    DB VENTURE BUILDER SL ES (VALENCIA) participant 131˙515.00
10    GENERA BIOTECH SL ES (PATERNA VALENCIA) participant 49˙734.00
11    ART OF TECHNOLOGY AG CH (ZURICH) participant 0.00

Map

 Project objective

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates. The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000. Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

 Publications

year authors and title journal last update
List of publications.
2019 L. Torrijos-Morán, J. García-Rupérez
Single-channel bimodal interferometric sensor using subwavelength structures
published pages: 8168, ISSN: 1094-4087, DOI: 10.1364/oe.27.008168
Optics Express 27/6 2019-09-09
2017 Odete Gonçalves, Scott Snider, Ruben Zadoyan, Quoc-Thang Nguyen, Henrik Vorum, Steffen B. Petersen, Maria Teresa Neves-Petersen
Novel microfabrication stage allowing for one-photon and multi-photon light assisted molecular immobilization and for multi-photon microscope
published pages: 100790F, ISSN: , DOI: 10.1117/12.2250567
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX 2019-09-09
2018 V.A. Papadimitriou, L.I. Segerink, A. van den Berg, J.C.T. Eijkel
3D capillary stop valves for versatile patterning inside microfluidic chips
published pages: 232-238, ISSN: 0003-2670, DOI: 10.1016/j.aca.2017.11.055
Analytica Chimica Acta 1000 2019-09-09
2019 Jad Sabek, Paula Martínez-Pérez, Jaime García-Rupérez
Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I
published pages: 147-151, ISSN: 1476-9271, DOI: 10.1016/j.compbiolchem.2019.04.002
Computational Biology and Chemistry 80 2019-09-09
2019 Jad Sabek, Luis Torrijos-Morán, Amadeu Griol, Zeneida Díaz Betancor, María-José Bañuls Polo, Ángel Maquieira, Jaime García-Rupérez
Real Time Monitoring of a UV Light-Assisted Biofunctionalization Protocol Using a Nanophotonic Biosensor
published pages: 6, ISSN: 2079-6374, DOI: 10.3390/bios9010006
Biosensors 9/1 2019-09-09
2018 Rafael Alonso, Pilar Jiménez-Meneses, Jaime García-Rupérez, María-José Bañuls, Ángel Maquieira
Thiol–ene click chemistry towards easy microarraying of half-antibodies
published pages: 6144-6147, ISSN: 1359-7345, DOI: 10.1039/c8cc01369a
Chemical Communications 54/48 2019-09-09
2019 María-José Bañuls, Miguel Ángel González-Martínez, Jad Sabek, Jaime García-Rupérez, Ángel Maquieira
Thiol-click photochemistry for surface functionalization applied to optical biosensing
published pages: 103-113, ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.01.055
Analytica Chimica Acta 1060 2019-09-09

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The information about "PHOCNOSIS" are provided by the European Opendata Portal: CORDIS opendata.

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