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Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT)

Total Cost €


EC-Contrib. €






Project "MULTIMOT" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website
 Total cost 2˙999˙354 €
 EC max contribution 2˙999˙354 € (100%)
 Programme 1. H2020-EU.3.1.6. (Health care provision and integrated care)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2018-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 576˙750.00
2    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 490˙680.00
4    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 364˙520.00
5    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 347˙038.00
6    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 340˙750.00
7    UNIVERSITEIT GENT BE (GENT) participant 144˙052.00
10    Idea Bio-Medical Ltd. IL (Rehovot) participant 62˙625.00


 Project objective

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migration thus has a direct impact on major clinical applications, especially regarding personalized treatment and diagnosis. Over the last few years, cell migration research has benefited enormously from advances in methodology and instrumentation, allowing multiplexing and multi-parameter post-processing of cell migration analyses to become widely used. As cell migration studies have thus de facto become both a high-content as well as a high-throughput science, an urgent yet largely unmet bioinformatics need has emerged in the form of intra- and inter-lab data management solutions, standardization and dissemination infrastructure, and novel approaches and algorithms for meta-analysis. The central goal of this project is therefore to construct a comprehensive, open and free data exchange ecosystem for cell migration data, based on the development of extensible community standards and a robust, future-proof repository that collects, annotates and disseminates these data in the standardized formats. The standards and repository will be supported by freely available and open source tools for data management, submission, extraction and analysis. Importantly, we will also demonstrate the application of large-scale integrative data analysis from cell migration studies through two proof-of-concept studies: guiding personalized cancer treatment from patient organoids, and providing patient-specific diagnosis based on peripheral blood leukocyte motility. This work will also establish the foundation for a cell migration science-based ELIXIR Node.


List of deliverables.
Implementation of REST and BioMart services Documents, reports 2019-03-22 09:53:17
Report on the development of multiscale analysis algorithms for complex multivariate data Documents, reports 2019-03-22 09:54:01
Standardized procedures and data sets from patient-derived tumor and immune cell models Documents, reports 2019-03-22 09:54:20
Report on the development of meta-scale analysis algorithms Documents, reports 2019-03-22 09:53:48
Submission of the second position paper Documents, reports 2019-03-22 09:54:14
Implementation of a discussion forum module Documents, reports 2019-03-22 09:53:36
Release of an open semantic validation framework for MIACME compliance verification Documents, reports 2019-03-22 09:52:31
Report on the two CMSO workshops and proceedings manuscripts in year 2 Documents, reports 2019-03-22 09:54:08
Release of a medical-oriented knowledgebase Documents, reports 2019-03-22 09:53:43
Support for the CMSO standards in IB’s relevant commercial software Documents, reports 2019-03-21 16:29:15
Implementation of automated MIACME compliance validation Documents, reports 2019-03-22 09:53:30
Release of a version of CellMissy that can import data from the public repository Documents, reports 2019-03-22 09:52:37
Report on the maintenance and updates carried out on the standard, and the plans for further support beyond project end Documents, reports 2019-03-21 16:29:33
Creation of project website Documents, reports 2019-03-22 17:18:30
Release of the standard format for cell migration data Documents, reports 2019-03-22 17:18:22
Release of standards compliant CellMissy version Documents, reports 2019-03-25 10:00:11
Report on the structures and approaches set up for maintenance and updates to the standards Documents, reports 2019-03-25 10:00:30
Submission of the first position paper Documents, reports 2019-03-25 10:00:21
Project progress report for Year 1 Documents, reports 2019-03-22 17:18:28
Report on the development of quality control algorithms Documents, reports 2019-03-25 10:00:21
Creation of the Cell Migration Standardization Organization (CMSO) Documents, reports 2019-03-22 17:18:28
Release of software libraries for the standard format Documents, reports 2019-03-25 10:00:07
First release of the functional repository Documents, reports 2019-03-22 17:18:32
Release of the MIACME minimal reporting requirements Documents, reports 2019-03-25 10:00:31
Report on the two CMSO workshops and proceedings manuscripts in year 1 Documents, reports 2019-03-25 10:00:21
Report on experimental procedures and multi-parameter analysis from tumor and immune cell models for computational multiscale analysis Documents, reports 2019-03-25 10:00:16
Report on the development of dedicated cell migration feature extraction algorithms Documents, reports 2019-03-22 17:18:29
Project progress report for Year 2 Documents, reports 2019-03-25 10:00:23
Report on the creation of a CV Documents, reports 2019-03-22 17:18:27
Requirements analysis for the cell migration repository Documents, reports 2019-03-25 10:00:21
Standardized, refined procedures and data sets from tumor and immune cell models for computational multi-scale analysis Documents, reports 2019-03-25 10:00:25
Report on the two CMSO workshops and proceedings manuscripts in year 3 Documents, reports 2019-03-21 16:29:17
Project progress report for Year 3 Documents, reports 2019-03-21 16:29:27

Take a look to the deliverables list in detail:  detailed list of MULTIMOT deliverables.


year authors and title journal last update
List of publications.
2018 Gwendolien Sergeant, Lennart Martens, Marleen Van Troys, Paola Masuzzo
DoRes within CellMissy: dose-response analysis on cell migration and related data
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty634
Bioinformatics 2019-05-24
2017 Peter Friedl, Roberto Mayor
Tuning Collective Cell Migration by Cell–Cell Junction Regulation
published pages: a029199, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a029199
Cold Spring Harbor Perspectives in Biology 9/4 2019-05-24
2017 Eleanor Williams, Josh Moore, Simon W Li, Gabriella Rustici, Aleksandra Tarkowska, Anatole Chessel, Simone Leo, Bálint Antal, Richard K Ferguson, Ugis Sarkans, Alvis Brazma, Rafael E Carazo Salas, Jason R Swedlow
Image Data Resource: a bioimage data integration and publication platform
published pages: 775-781, ISSN: 1548-7091, DOI: 10.1038/nmeth.4326
Nature Methods 14/8 2019-05-24
2016 Whetzel, Patricia L; Overton, James A.; Phillip Lord; Yu Lin; Jennifer Fostel; Monnie McGee; Anita Bandrowski; Ryan Brinkman; Stoeckert, Christian J.; Chibucos, Marcus C.; Bjoern Peters; Helen Parkinson; Soldatova, Larisa N; James Malone; Taylor, Chris F; Mathias Brochhausen; Lister, Allyson L; Kevin Clancy; Philippe Rocca-Serra; Mark Jensen; Susanna-Assunta Sansone; Carlo Torniai; Michel Dumontier; Haendel, Melissa A.; Barry Smith; Tina Hernandez-Boussard; Alejandra Gonzalez-Beltran; Daniel Schober; Elisabetta Manduchi; Randi Vita; Jessica A Turner; Brush, Matthew H; Dirk Derom; Bill Bug; Mélanie Courtot; Jie Zheng; Mervi Heiskanen; Norman Morrison; Scheuermann, Richard H; Yongqun He; Gilberto Fragoso; Frank Gibson; Alan Ruttenberg; Liju Fan
The ontology for biomedical investigations
published pages: p e0154556, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0154556
PLoS ONE 11 2019-05-24
2017 Paola Masuzzo, Lynn Huyck, Aleksandra Simiczyjew, Christophe Ampe, Lennart Martens, Marleen Van Troys
An end-to-end software solution for the analysis of high-throughput single-cell migration data
published pages: 42383, ISSN: 2045-2322, DOI: 10.1038/srep42383
Scientific Reports 7 2019-05-24
2016 Jonathan P. Tennant, François Waldner, Damien C. Jacques, Paola Masuzzo, Lauren B. Collister, Chris. H. J. Hartgerink
The academic, economic and societal impacts of Open Access: an evidence-based review
published pages: 632, ISSN: 2046-1402, DOI: 10.12688/f1000research.8460.1
F1000Research 5 2019-05-24
2017 Anika Klingberg, Anja Hasenberg, Isis Ludwig-Portugall, Anna Medyukhina, Linda Männ, Alexandra Brenzel, Daniel R. Engel, Marc Thilo Figge, Christian Kurts, Matthias Gunzer
Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy
published pages: 452-459, ISSN: 1046-6673, DOI: 10.1681/ASN.2016020232
Journal of the American Society of Nephrology 28/2 2019-05-24

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