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MITOPLASTICITY SIGNED

Mitochondrial regulation of structural and functional plasticity within adult neurogenic circuits

Total Cost €

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EC-Contrib. €

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Partnership

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 MITOPLASTICITY project word cloud

Explore the words cloud of the MITOPLASTICITY project. It provides you a very rough idea of what is the project "MITOPLASTICITY" about.

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Project "MITOPLASTICITY" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM DER UNIVERSITAET ZU KOELN 

Organization address
address: Kerpener Strasse 62
city: KOELN
postcode: 50937
website: www.uk-koeln.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://bergami-lab.com/
 Total cost 1˙199˙987 €
 EC max contribution 1˙199˙987 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) coordinator 1˙199˙987.00

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 Project objective

A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. in response to experience or disease. We have recently shown that a regionalized restructuring of the mitochondrial network in astrocytes upon cortical injury underlies their ability to enter a state of reactivity and sustain cellular energy metabolism, suggesting that local changes in mitochondrial network architecture govern cellular adaptations in register with local metabolic demand. Here, I focus on the adult hippocampal circuitry and its almost unique structural plasticity to broaden this fundamental concept and evaluate whether local mitochondrial remodelling orchestrates the metabolic changes underlying the directed genesis of new neurons and their evolving connectivity in face of experience. First, we will utilize state-of-the-art imaging and genetic techniques to investigate the precise role of mitochondria in regulating adult neural stem cells (NSCs) quiescence, mode of division and neurogenic potential in response to experience. This will set the stage for examining whether state-specific energy metabolism programs regulate the fate plasticity of adult NSCs, as following their directed differentiation towards distinct lineages in vivo (Aim I). We will then elucidate whether mitochondria contribute to mechanisms of metabolic and synaptic competition in new neurons, in particular to their critical period of heightened structural and functional synaptic plasticity (Aim II). Lastly, we will use novel tracing techniques to dissect the local energy needs for activity- and experience-dependent remodelling of new neuron functional connectivity (Aim III).

 Publications

year authors and title journal last update
List of publications.
2018 Hannah Maria Jahn, Matteo Bergami
Critical periods regulating the circuit integration of adult-born hippocampal neurons
published pages: 23-32, ISSN: 0302-766X, DOI: 10.1007/s00441-017-2677-x
Cell and Tissue Research 371/1 2019-06-19
2017 Jana Göbel, Elisa Motori, Matteo Bergami
Spatiotemporal control of mitochondrial network dynamics in astroglial cells
published pages: , ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2017.06.191
Biochemical and Biophysical Research Communications 2019-06-19
2019 Hans‐Georg Sprenger, Gulzar Wani, Annika Hesseling, Tim König, Maria Patron, Thomas MacVicar, Sofia Ahola, Timothy Wai, Esther Barth, Elena I Rugarli, Matteo Bergami, Thomas Langer
Loss of the mitochondrial i ‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy
published pages: e9288, ISSN: 1757-4676, DOI: 10.15252/emmm.201809288
EMBO Molecular Medicine 11/1 2019-04-18
2019 Sophie Riedemann, Bernd Sutor, Matteo Bergami, Therese Riedemann
Gad1‐promotor‐driven GFP expression in non‐GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line
published pages: , ISSN: 0021-9967, DOI: 10.1002/cne.24673
Journal of Comparative Neurology 2019-04-16

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