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BIOCASCADES- Sustainable and Scalable Biocatalytic Cascade Reactions Training Network

Total Cost €


EC-Contrib. €






Project "BIOCASCADES" data sheet

The following table provides information about the project.


Organization address
city: GRAZ
postcode: 8010

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 2˙787˙956 €
 EC max contribution 2˙787˙956 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-EID
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET GRAZ AT (GRAZ) coordinator 255˙934.00
3    SAROMICS BIOSTRUCTURES AB SE (Lund) participant 263˙659.00
4    VIAZYM BV NL (DELFT) participant 255˙374.00
5    ENZYMICALS AG DE (GREIFSWALD) participant 249˙216.00
6    RUHR-UNIVERSITAET BOCHUM DE (BOCHUM) participant 249˙216.00
8    UNIVERSITAET BIELEFELD DE (BIELEFELD) participant 249˙216.00
10    DSM CHEMICAL TECHNOLOGY R & D BV NL (SITTARD) participant 134˙780.00
11    ENTRECHEM SL ES (OVIEDO) participant 123˙936.00
12    UNIVERSIDAD DE OVIEDO ES (OVIEDO) participant 123˙936.00
13    INNOSYN BV NL (GELEEN) participant 120˙593.00


 Project objective

In BIOCASCADES, nine early-stage researchers (ESRs) will investigate the development of sustainable (chemo)enzymatic cascade reactions under the ‘green chemistry’ philosophy. The proposed BIOCASCADES project combines different techniques such as compartmentalization, protein engineering and reaction engineering in order to develop commercially viable and environmentally benign one pot reactions. By avoiding intermediate downstream- and purification-steps, cascade reactions minimize production costs, energy demand and waste production and are thus expected to make a major contribution for the development of sustainable and efficient production processes.

Small- and medium sized enterprises (SMEs) are emerging as main drivers of European Research. They are dynamic, explore new areas and create new ideas, while large companies rely more and more on outsourcing research or involving SMEs by joint ventures. However, small companies are not strong enough as stand-alone enterprises, which requires them to form networks with other SMEs and academia. This creates a strong demand for young researchers who can move freely in an international and interdisciplinary environment. In a tailor-made training program BIOCASCADES aims to provide the nine early stage researchers with specific scientific and transferable skills for careers in the highly dynamic European biotechnology sector. Training at leading laboratories of biocatalysis will develop their scientific skills, while secondments to the industry and specific workshops will develop their entrepreneurship. The graduates of this doctorate program will be highly qualified for collaborative research between European academia and industry.

The consortium is formed by leading academic laboratories from biocatalysis and protein engineering together with a network of four innovative biotech companies. By combining their versatile expertise, the consortium can achieve a success that would not be possible in isolated projects.


List of deliverables.
Summer school & training events Documents, reports 2019-07-22 14:33:07
Dissemination and public engagement report Documents, reports 2019-07-22 14:33:07
Website Websites, patent fillings, videos etc. 2019-07-22 14:33:07
Committees Documents, reports 2019-07-22 14:33:07

Take a look to the deliverables list in detail:  detailed list of BIOCASCADES deliverables.


year authors and title journal last update
List of publications.
2017 Sandy Schmidt, Harald Gröger, Robert Kourist
Durch Trennen verbinden
published pages: 985-988, ISSN: 1439-9598, DOI: 10.1002/nadc.20174058532
Nachrichten aus der Chemie 65/10 2019-07-22
2017 Elisa Liardo, Nicolás Ríos-Lombardía, Francisco Morís, Francisca Rebolledo, Javier González-Sabín
Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium
published pages: 4768-4774, ISSN: 2155-5435, DOI: 10.1021/acscatal.7b01543
ACS Catalysis 7/7 2019-07-22
2019 Aline Telzerow, Juraj Paris, Maria Håkansson, Javier González-Sabín, Nicolás Ríos-Lombardía, Martin Schürmann, Harald Gröger, Francisco Morís, Robert Kourist, Helmut Schwab, Kerstin Steiner
Amine Transaminase from Exophiala Xenobiotica —Crystal Structure and Engineering of a Fold IV Transaminase that Naturally Converts Biaryl Ketones
published pages: 1140-1148, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b04524
ACS Catalysis 9/2 2019-07-22
2019 Juraj Paris, Aline Telzerow, Nicolás Ríos-Lombardía, Kerstin Steiner, Helmut Schwab, Francisco Morís, Harald Gröger, Javier González-Sabín
Enantioselective One-Pot Synthesis of Biaryl-Substituted Amines by Combining Palladium and Enzyme Catalysis in Deep Eutectic Solvents
published pages: , ISSN: 2168-0485, DOI: 10.1021/acssuschemeng.8b06715
ACS Sustainable Chemistry & Engineering 2019-07-22
2018 Juraj Paris, Nicolás Ríos‐Lombardía, Francisco Morís, Harald Gröger, Javier González‐Sabín
Novel Insights into the Combination of Metal‐ and Biocatalysis: Cascade One‐Pot Synthesis of Enantiomerically Pure Biaryl Alcohols in Deep Eutectic Solvents
published pages: 4417-4423, ISSN: 1867-3880, DOI: 10.1002/cctc.201800768
ChemCatChem 10/19 2019-07-22
2017 Robert Kourist, Javier González-Sabín, Bettina Siebers, Mattijs Julsing
Editorial: Applied Microbiology for Chemical Syntheses
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01931
Frontiers in Microbiology 8 2019-07-22
2018 Raquel S. Correia Cordeiro, Junichi Enoki, Florian Busch, Carolin Mügge, Robert Kourist
Cloning and characterization of a new delta-specific l-leucine dioxygenase from Anabaena variabilis
published pages: 68-74, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.07.038
Journal of Biotechnology 284 2019-07-22
2019 Raquel S. Correia Cordeiro, Nicolás Ríos-Lombardía, Francisco Morís, Robert Kourist, Javier González-Sabín
One-Pot Transformation of Ketoximes into Optically Active Alcohols and Amines by Sequential Action of Laccases and Ketoreductases or ω-Transaminases
published pages: 1272-1277, ISSN: 1867-3880, DOI: 10.1002/cctc.201801900
ChemCatChem 11/4 2019-07-22
2018 Lisa Marx, Nicolás Ríos-Lombardía, Judith F. Farnberger, Wolfgang Kroutil, Ana I. Benítez-Mateos, Fernando López-Gallego, Francisco Morís, Javier González-Sabín, Per Berglund
Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases
published pages: 2157-2165, ISSN: 1615-4150, DOI: 10.1002/adsc.201701485
Advanced Synthesis & Catalysis 360/11 2019-07-22
2018 Federica Ruggieri, Luuk M. van Langen, Derek T. Logan, Björn Walse, Per Berglund
Transaminase-Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions
published pages: 5012-5018, ISSN: 1867-3880, DOI: 10.1002/cctc.201801049
ChemCatChem 10/21 2019-07-22
2019 Wuyuan Zhang, Elena Fernandez Fueyo, Frank Hollmann, Laura Leemans Martin, Milja Pesic, Rainer Wardenga, Matthias Höhne, Sandy Schmidt
Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization
published pages: 80-84, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801692
European Journal of Organic Chemistry 2019/1 2019-07-22
2019 Elia Calderini, Julia Wessel, Philipp Süss, Patrick Schrepfer, Rainer Wardenga, Anett Schallmey
Selective Ring-Opening of Di-substituted Epoxides Catalysed by Halohydrin Dehalogenases
published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201900103
ChemCatChem 2019-07-22
2016 Nicolás Ríos-Lombardía, Cristian Vidal, Elisa Liardo, Francisco Morís, Joaquín García-Álvarez, Javier González-Sabín
From a Sequential to a Concurrent Reaction in Aqueous Medium: Ruthenium-Catalyzed Allylic Alcohol Isomerization and Asymmetric Bioreduction
published pages: 8691-8695, ISSN: 1433-7851, DOI: 10.1002/anie.201601840
Angewandte Chemie International Edition 55/30 2019-07-22
2018 Elisa Liardo, Nicolás Ríos-Lombardía, Francisco Morís, Javier González-Sabín, Francisca Rebolledo
A Straightforward Deracemization of sec -Alcohols Combining Organocatalytic Oxidation and Biocatalytic Reduction
published pages: 3031-3035, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800569
European Journal of Organic Chemistry 2018/23 2019-07-22
2018 Harald Gröger, Robert Kourist, Anett Schallmey
Achte CeBiTec Research Conference
published pages: 904-904, ISSN: 1439-9598, DOI: 10.1002/nadc.20184077274
Nachrichten aus der Chemie 66/9 2019-07-22
2018 Elisa Liardo, Rebeca González-Fernández, Nicolás Ríos-Lombardía, Francisco Morís, Joaquín García-Álvarez, Victorio Cadierno, Pascale Crochet, Francisca Rebolledo, Javier González-Sabín
Strengthening the Combination between Enzymes and Metals in Aqueous Medium: Concurrent Ruthenium-Catalyzed Nitrile Hydration - Asymmetric Ketone Bioreduction
published pages: 4676-4682, ISSN: 1867-3880, DOI: 10.1002/cctc.201801005
ChemCatChem 10/20 2019-07-22
2016 Elisa Liardo, Nicolás Ríos-Lombardía, Francisco Morís, Javier González-Sabín, Francisca Rebolledo
Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles
published pages: 3366-3369, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01510
Organic Letters 18/14 2019-07-22

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