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CNIDARIAMICRORNA SIGNED

Elucidation of the evolution of post-transcriptional regulation by characterizing the cnidarian microRNA pathway

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EC-Contrib. €

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Partnership

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 CNIDARIAMICRORNA project word cloud

Explore the words cloud of the CNIDARIAMICRORNA project. It provides you a very rough idea of what is the project "CNIDARIAMICRORNA" about.

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Project "CNIDARIAMICRORNA" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://yehumoran.com
 Total cost 1˙499˙587 €
 EC max contribution 1˙499˙587 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙499˙587.00

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 Project objective

Over the past decade small RNAs such as microRNAs (miRNAs) and small interfering RNAs (siRNAs) have been shown to carry pivotal roles in post-transcriptional regulation and genome protection and to play an important part in various physiological processes in animals. miRNAs can be found in a very wide range of animals yet their functions were studied almost exclusively in members of the Bilateria such as insects, nematodes and vertebrates. Hence studying their function in representatives of non-bilaterian phyla such as Cnidaria (sea anemones, corals, hydras and jellyfish) is crucial for understanding the evolution of miRNAs in animals and can provide important insights into their roles in the ancient ancestor of Cnidaria and Bilateria. The sea anemone Nematostella vectensis is an excellent model for such a study since it can be grown in large numbers throughout its life cycle in the lab and because well-established genetic manipulation techniques are available for this species. Our preliminary results indicate that miRNAs in Nematostella frequently have a nearly perfect match to their messenger RNA (mRNA) targets, resulting in cleavage of the target. This mode of action is common for plant miRNAs, but is very rare in Bilateria. This finding together with my recent discovery of a Nematostella homolog of HYL1, a protein involved in miRNA biogenesis in plants, raises the exciting possibility that the miRNA pathway existed in the common ancestor of plants and animals. Here I suggest to bring together an array of advanced biochemical and genetic methods such as gene knockdown, transgenesis, high throughput sequencing and immunoprecipitation in order to obtain - for the first time - a deep understanding of the biogenesis and mechanism of action of small RNAs in Cnidaria. This will provide a novel way to understand the evolution of this important molecular pathway and to evaluate its age and ancestral form.

 Publications

year authors and title journal last update
List of publications.
2017 Vengamanaidu Modepalli, Yehu Moran
Evolution of miRNA Tailing by 3′ Terminal Uridylyl Transferases in Metazoa
published pages: 1547-1560, ISSN: 1759-6653, DOI: 10.1093/gbe/evx106
Genome Biology and Evolution 9/6 2019-05-28
2017 Daniela Praher, Bob Zimmermann, Grigory Genikhovich, Yaara Columbus-Shenkar, Vengamanaidu Modepalli, Reuven Aharoni, Yehu Moran, Ulrich Technau
Characterization of the piRNA pathway during development of the sea anemone Nematostella vectensis
published pages: 1727-1741, ISSN: 1547-6286, DOI: 10.1080/15476286.2017.1349048
RNA Biology 14/12 2019-05-28
2017 Marta Mauri, Marieluise Kirchner, Reuven Aharoni, Camilla Ciolli Mattioli, David van den Bruck, Nadya Gutkovitch, Vengamanaidu Modepalli, Matthias Selbach, Yehu Moran, Marina Chekulaeva
Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution
published pages: 938-950, ISSN: 0305-1048, DOI: 10.1093/nar/gkw792
Nucleic Acids Research 45/2 2019-05-28
2017 Yehu Moran, Maayan Agron, Daniela Praher, Ulrich Technau
The evolutionary origin of plant and animal microRNAs
published pages: 27, ISSN: 2397-334X, DOI: 10.1038/s41559-016-0027
Nature Ecology & Evolution 1/3 2019-05-28

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