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Unraveling the regulatory network of developmental programmed cell death in plants

Total Cost €


EC-Contrib. €






 PROCELLDEATH project word cloud

Explore the words cloud of the PROCELLDEATH project. It provides you a very rough idea of what is the project "PROCELLDEATH" about.

complementary    despite    vasculature    arabidopsis    combines    disrupt    execute    cells    fundamental    questions    computational    differentiation    initiate    seeds    imaging    existence    pcd    obtain    mechanism    easily    network    health    organs    regulation    plant    cap    point    precisely    powerful    stresses    right    tackle    core    programmed    death    periphery    root    exist    revolutionize    types    answers    strategy    data    ordered    unresolved    abundance    moment    little    leads    determined    tap    vital    biochemistry    stages    functions    sequence    genetics    unpublished    anthers    me    mechanisms    transcriptomics    live    plants    signals    animals    competency    modeling    cell    actively    renders    occurring    accessible    advantage    generate    reverse    acquire    regulatory    biological    competent    molecular    intricate    trigger    thaliana    actual    combining    predictable    developmental    agriculture    model    underexploited    events    terminates   

Project "PROCELLDEATH" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website
 Total cost 1˙499˙746 €
 EC max contribution 1˙499˙746 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙499˙746.00


 Project objective

Programmed cell death (PCD) is a fundamental biological process that actively terminates a cell’s vital functions by a well-ordered sequence of events. In both animals and plants, various types of PCD are crucial for development, health, and the responses to various stresses. Despite their importance, only little is known about PCD processes and their molecular control in plants. Still, an intricate regulatory network must exist that renders specific plant cell types competent to initiate and execute PCD at precisely determined developmental stages. I recently established a powerful developmental PCD model system in Arabidopsis thaliana, based on a PCD process occurring during root cap development. This root cap model has the potential to revolutionize existing concepts of plant PCD, as it combines a precisely predictable PCD process in easily accessible cells on the root periphery with the abundance of resources available for Arabidopsis research. Exploiting the root cap system will enable me to tackle unresolved fundamental questions about the regulation of developmental PCD in plants: How do cells acquire PCD competency during differentiation? Which signals trigger PCD execution at just the right moment? What are the actual mechanisms that disrupt the vital functions of a plant cell? I will obtain answers to these questions through a comprehensive strategy combining complementary approaches, taking advantage of cell-type specific transcriptomics, forward and reverse genetics, advanced live-cell imaging, biochemistry, and computational modeling. Our unpublished data point to the existence of a common core mechanism controlling PCD not only in the root cap, but also in other vital organs including the vasculature, anthers, or developing seeds. Thus, this project will not only be significant to advance our knowledge on PCD as a general developmental mechanism in plants, but also to generate new leads to tap the so far underexploited potential of PCD in agriculture.


year authors and title journal last update
List of publications.
2018 Rahul Bhosale, Veronique Boudolf, Fabiola Cuevas, Ran Lu, Thomas Eekhout, Zhubing Hu, Gert Van Isterdael, Georgina M. Lambert, Fan Xu, Moritz K. Nowack, Richard S. Smith, Ilse Vercauteren, Riet De Rycke, Veronique Storme, Tom Beeckman, John C. Larkin, Anna Kremer, Herman Höfte, David W. Galbraith, Robert P. Kumpf, Steven Maere, Lieven De Veylder
A Spatiotemporal DNA Endoploidy Map of the Arabidopsis Root Reveals Roles for the Endocycle in Root Development and Stress Adaptation
published pages: 2330-2351, ISSN: 1040-4651, DOI: 10.1105/tpc.17.00983
The Plant Cell 30/10 2019-12-16
2019 Kjell De Vriese, Ellie Himschoot, Kai Dünser, Long Nguyen, Andrzej Drozdzecki, Alex Costa, Moritz K. Nowack, Jürgen Kleine-Vehn, Dominique Audenaert, Tom Beeckman, Steffen Vanneste
Identification of Novel Inhibitors of Auxin-Induced Ca 2+ Signaling via a Plant-Based Chemical Screen
published pages: 480-496, ISSN: 0032-0889, DOI: 10.1104/pp.18.01393
Plant Physiology 180/1 2019-12-16
2018 Zhen Gao, Anna Daneva, Yuliya Salanenka, Matthias Van Durme, Marlies Huysmans, Zongcheng Lin, Freya De Winter, Steffen Vanneste, Mansour Karimi, Jan Van de Velde, Klaas Vandepoele, Davy Van de Walle, Koen Dewettinck, Bart N. Lambrecht, Moritz K. Nowack
KIRA1 and ORESARA1 terminate flower receptivity by promoting cell death in the stigma of Arabidopsis
published pages: 365-375, ISSN: 2055-0278, DOI: 10.1038/s41477-018-0160-7
Nature Plants 4/6 2019-12-16
2018 Marlies Huysmans, Rafael Andrade Buono, Noemi Skorzinski, Marta Cubria Radio, Freya De Winter, Boris Parizot, Jan Mertens, Mansour Karimi, Matyas Fendrych, Moritz K. Nowack
NAC Transcription Factors ANAC087 and ANAC046 Control Distinct Aspects of Programmed Cell Death in the Arabidopsis Columella and Lateral Root Cap
published pages: 2197-2213, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00293
The Plant Cell 30/9 2019-12-16
2019 Ward Decaestecker, Rafael Andrade Buono, Marie Pfeiffer, Nick Vangheluwe, Joris Jourquin, Mansour Karimi, Gert van Isterdael, Tom Beeckman, Moritz K Nowack, Thomas B Jacobs
CRISPR-TSKO: A Technique for Efficient Mutagenesis in Specific Cell Types, Tissues, or Organs in Arabidopsis
published pages: tpc.00454.2019, ISSN: 1040-4651, DOI: 10.1105/tpc.19.00454
The Plant Cell 2019-12-16
2017 Marlies Huysmans, Saul Lema A, Nuria S Coll, Moritz K Nowack
Dying two deaths — programmed cell death regulation in development and disease
published pages: 37-44, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2016.11.005
Current Opinion in Plant Biology 35 2019-05-29
2015 Robert P. Kumpf, Moritz K. Nowack
The root cap: a short story of life and death
published pages: 5651-5662, ISSN: 0022-0957, DOI: 10.1093/jxb/erv295
Journal of Experimental Botany 66/19 2019-05-29
Developing 3D SEM in a broad biological context
published pages: 80-96, ISSN: 0022-2720, DOI: 10.1111/jmi.12211
Journal of Microscopy 259/2 2019-05-29
2016 W. Xuan, L. R. Band, R. P. Kumpf, D. Van Damme, B. Parizot, G. De Rop, D. Opdenacker, B. K. Moller, N. Skorzinski, M. F. Njo, B. De Rybel, D. Audenaert, M. K. Nowack, S. Vanneste, T. Beeckman
Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis
published pages: 384-387, ISSN: 0036-8075, DOI: 10.1126/science.aad2776
Science 351/6271 2019-05-29
2017 Mathieu Ingouff, Benjamin Selles, Caroline Michaud, Thiet M. Vu, Frédéric Berger, Andrea J. Schorn, Daphné Autran, Matthias Van Durme, Moritz K. Nowack, Robert A. Martienssen, Daniel Grimanelli
Live-cell analysis of DNA methylation during sexual reproduction in Arabidopsis reveals context and sex-specific dynamics controlled by noncanonical RdDM
published pages: 72-83, ISSN: 0890-9369, DOI: 10.1101/gad.289397.116
Genes & Development 31/1 2019-05-29
2015 Yadira Olvera-Carrillo, Michiel Van Bel, Tom Van Hautegem, Matyas Fendrych, Matthias Van Durme, Marlies Huysmans, Mária Šimášková, Pierre Buscaill, Susana Rivas, Nuria S. Coll, Steven Maere, Frederik Coppens, Moritz K Nowack
A conserved core of PCD indicator genes discriminates developmentally and environmentally induced programmed cell death in plants
published pages: pp.00769.2015, ISSN: 0032-0889, DOI: 10.1104/pp.15.00769
Plant Physiology 2019-05-29
2016 Anna Daneva, Zhen Gao, Matthias Van Durme, Moritz K. Nowack
Functions and Regulation of Programmed Cell Death in Plant Development
published pages: 441-468, ISSN: 1081-0706, DOI: 10.1146/annurev-cellbio-111315-124915
Annual Review of Cell and Developmental Biology 32/1 2019-05-29
2016 Matthias Van Durme, Moritz K Nowack
Mechanisms of developmentally controlled cell death in plants
published pages: 29-37, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2015.10.013
Current Opinion in Plant Biology 29 2019-05-29

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