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PROCELLDEATH SIGNED

Unraveling the regulatory network of developmental programmed cell death in plants

Total Cost €

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EC-Contrib. €

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Partnership

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 PROCELLDEATH project word cloud

Explore the words cloud of the PROCELLDEATH project. It provides you a very rough idea of what is the project "PROCELLDEATH" about.

me    exist    pcd    abundance    trigger    seeds    generate    biochemistry    cap    easily    execute    revolutionize    combines    determined    root    vital    underexploited    agriculture    transcriptomics    network    events    data    regulatory    plant    signals    core    molecular    renders    regulation    actively    death    answers    periphery    stages    actual    reverse    animals    live    imaging    thaliana    organs    unpublished    leads    precisely    health    right    functions    mechanisms    fundamental    cells    tackle    plants    cell    vasculature    programmed    initiate    competent    competency    unresolved    moment    stresses    modeling    genetics    accessible    little    despite    tap    sequence    combining    arabidopsis    existence    complementary    ordered    predictable    differentiation    model    mechanism    biological    intricate    occurring    point    types    anthers    disrupt    developmental    acquire    strategy    powerful    questions    obtain    computational    advantage    terminates   

Project "PROCELLDEATH" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.vib.be/en/research/scientists/Pages/Moritz-Nowack-Lab.aspx
 Total cost 1˙499˙746 €
 EC max contribution 1˙499˙746 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙499˙746.00

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 Project objective

Programmed cell death (PCD) is a fundamental biological process that actively terminates a cell’s vital functions by a well-ordered sequence of events. In both animals and plants, various types of PCD are crucial for development, health, and the responses to various stresses. Despite their importance, only little is known about PCD processes and their molecular control in plants. Still, an intricate regulatory network must exist that renders specific plant cell types competent to initiate and execute PCD at precisely determined developmental stages. I recently established a powerful developmental PCD model system in Arabidopsis thaliana, based on a PCD process occurring during root cap development. This root cap model has the potential to revolutionize existing concepts of plant PCD, as it combines a precisely predictable PCD process in easily accessible cells on the root periphery with the abundance of resources available for Arabidopsis research. Exploiting the root cap system will enable me to tackle unresolved fundamental questions about the regulation of developmental PCD in plants: How do cells acquire PCD competency during differentiation? Which signals trigger PCD execution at just the right moment? What are the actual mechanisms that disrupt the vital functions of a plant cell? I will obtain answers to these questions through a comprehensive strategy combining complementary approaches, taking advantage of cell-type specific transcriptomics, forward and reverse genetics, advanced live-cell imaging, biochemistry, and computational modeling. Our unpublished data point to the existence of a common core mechanism controlling PCD not only in the root cap, but also in other vital organs including the vasculature, anthers, or developing seeds. Thus, this project will not only be significant to advance our knowledge on PCD as a general developmental mechanism in plants, but also to generate new leads to tap the so far underexploited potential of PCD in agriculture.

 Publications

year authors and title journal last update
List of publications.
2018 Rahul Bhosale, Veronique Boudolf, Fabiola Cuevas, Ran Lu, Thomas Eekhout, Zhubing Hu, Gert Van Isterdael, Georgina M. Lambert, Fan Xu, Moritz K. Nowack, Richard S. Smith, Ilse Vercauteren, Riet De Rycke, Veronique Storme, Tom Beeckman, John C. Larkin, Anna Kremer, Herman Höfte, David W. Galbraith, Robert P. Kumpf, Steven Maere, Lieven De Veylder
A Spatiotemporal DNA Endoploidy Map of the Arabidopsis Root Reveals Roles for the Endocycle in Root Development and Stress Adaptation
published pages: 2330-2351, ISSN: 1040-4651, DOI: 10.1105/tpc.17.00983
The Plant Cell 30/10 2019-12-16
2019 Kjell De Vriese, Ellie Himschoot, Kai Dünser, Long Nguyen, Andrzej Drozdzecki, Alex Costa, Moritz K. Nowack, Jürgen Kleine-Vehn, Dominique Audenaert, Tom Beeckman, Steffen Vanneste
Identification of Novel Inhibitors of Auxin-Induced Ca 2+ Signaling via a Plant-Based Chemical Screen
published pages: 480-496, ISSN: 0032-0889, DOI: 10.1104/pp.18.01393
Plant Physiology 180/1 2019-12-16
2018 Zhen Gao, Anna Daneva, Yuliya Salanenka, Matthias Van Durme, Marlies Huysmans, Zongcheng Lin, Freya De Winter, Steffen Vanneste, Mansour Karimi, Jan Van de Velde, Klaas Vandepoele, Davy Van de Walle, Koen Dewettinck, Bart N. Lambrecht, Moritz K. Nowack
KIRA1 and ORESARA1 terminate flower receptivity by promoting cell death in the stigma of Arabidopsis
published pages: 365-375, ISSN: 2055-0278, DOI: 10.1038/s41477-018-0160-7
Nature Plants 4/6 2019-12-16
2018 Marlies Huysmans, Rafael Andrade Buono, Noemi Skorzinski, Marta Cubria Radio, Freya De Winter, Boris Parizot, Jan Mertens, Mansour Karimi, Matyas Fendrych, Moritz K. Nowack
NAC Transcription Factors ANAC087 and ANAC046 Control Distinct Aspects of Programmed Cell Death in the Arabidopsis Columella and Lateral Root Cap
published pages: 2197-2213, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00293
The Plant Cell 30/9 2019-12-16
2019 Ward Decaestecker, Rafael Andrade Buono, Marie Pfeiffer, Nick Vangheluwe, Joris Jourquin, Mansour Karimi, Gert van Isterdael, Tom Beeckman, Moritz K Nowack, Thomas B Jacobs
CRISPR-TSKO: A Technique for Efficient Mutagenesis in Specific Cell Types, Tissues, or Organs in Arabidopsis
published pages: tpc.00454.2019, ISSN: 1040-4651, DOI: 10.1105/tpc.19.00454
The Plant Cell 2019-12-16
2017 Marlies Huysmans, Saul Lema A, Nuria S Coll, Moritz K Nowack
Dying two deaths — programmed cell death regulation in development and disease
published pages: 37-44, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2016.11.005
Current Opinion in Plant Biology 35 2019-05-29
2015 Robert P. Kumpf, Moritz K. Nowack
The root cap: a short story of life and death
published pages: 5651-5662, ISSN: 0022-0957, DOI: 10.1093/jxb/erv295
Journal of Experimental Botany 66/19 2019-05-29
2015 A. KREMER, S. LIPPENS, S. BARTUNKOVA, B. ASSELBERGH, C. BLANPAIN, M. FENDRYCH, A. GOOSSENS, M. HOLT, S. JANSSENS, M. KROLS, J.-C. LARSIMONT, C. Mc GUIRE, M.K. NOWACK, X. SAELENS, A. SCHERTEL, B. SCHEPENS, M. SLEZAK, V. TIMMERMAN, C. THEUNIS, R. VAN BREMPT, Y. VISSER, C.J. GUÉRIN
Developing 3D SEM in a broad biological context
published pages: 80-96, ISSN: 0022-2720, DOI: 10.1111/jmi.12211
Journal of Microscopy 259/2 2019-05-29
2016 W. Xuan, L. R. Band, R. P. Kumpf, D. Van Damme, B. Parizot, G. De Rop, D. Opdenacker, B. K. Moller, N. Skorzinski, M. F. Njo, B. De Rybel, D. Audenaert, M. K. Nowack, S. Vanneste, T. Beeckman
Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis
published pages: 384-387, ISSN: 0036-8075, DOI: 10.1126/science.aad2776
Science 351/6271 2019-05-29
2017 Mathieu Ingouff, Benjamin Selles, Caroline Michaud, Thiet M. Vu, Frédéric Berger, Andrea J. Schorn, Daphné Autran, Matthias Van Durme, Moritz K. Nowack, Robert A. Martienssen, Daniel Grimanelli
Live-cell analysis of DNA methylation during sexual reproduction in Arabidopsis reveals context and sex-specific dynamics controlled by noncanonical RdDM
published pages: 72-83, ISSN: 0890-9369, DOI: 10.1101/gad.289397.116
Genes & Development 31/1 2019-05-29
2015 Yadira Olvera-Carrillo, Michiel Van Bel, Tom Van Hautegem, Matyas Fendrych, Matthias Van Durme, Marlies Huysmans, Mária Šimášková, Pierre Buscaill, Susana Rivas, Nuria S. Coll, Steven Maere, Frederik Coppens, Moritz K Nowack
A conserved core of PCD indicator genes discriminates developmentally and environmentally induced programmed cell death in plants
published pages: pp.00769.2015, ISSN: 0032-0889, DOI: 10.1104/pp.15.00769
Plant Physiology 2019-05-29
2016 Anna Daneva, Zhen Gao, Matthias Van Durme, Moritz K. Nowack
Functions and Regulation of Programmed Cell Death in Plant Development
published pages: 441-468, ISSN: 1081-0706, DOI: 10.1146/annurev-cellbio-111315-124915
Annual Review of Cell and Developmental Biology 32/1 2019-05-29
2016 Matthias Van Durme, Moritz K Nowack
Mechanisms of developmentally controlled cell death in plants
published pages: 29-37, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2015.10.013
Current Opinion in Plant Biology 29 2019-05-29

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