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Circadian Regulation Of Brown Adipose Thermogenesis

Total Cost €


EC-Contrib. €






 aCROBAT project word cloud

Explore the words cloud of the aCROBAT project. It provides you a very rough idea of what is the project "aCROBAT" about.

transcriptional    blood    diseases    rna    expending    drive    capacity    effectors    calorie    cell    source    combating    customized    strategies    dissipating    conserved    cutting    fundamental    daily    link    evolutionary    hormonal    small    shape    generation    gain    tissue    anticipation    preliminary    discovered    abrupt    diabetes    edge    insights    incorporates    extend    mass    enzymes    networks    framework    constraints    pharmacological    input    mechanistic    surface    question    reached    environmental    borne    obesity    facets    sequencing    energy    harness    unappreciated    additionally    possesses    orchestrate    critically    network    maintaining    primary    phenotyping    cues    oscillations    crosstalk    previously    physiological    mouse    mammals    bioenergetic    rhythms    signaling    nutrient    treatment    proportions    neuronal    heat    thermogenic    humans    metabolism    metabolic    circadian    reveal    coordinately    group    brown    candidates    models    direct    burning    functions    yielded    pandemic    stress    translational    validations    therapeutic    adipose    spectrometry    function    rhythm    bat    newly    unlock    receptors    adapt    vivo    prevention    regulation    vitro    demand   

Project "aCROBAT" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙497˙007 €
 EC max contribution 1˙497˙007 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙497˙007.00


 Project objective

Obesity and diabetes have reached pandemic proportions and new therapeutic strategies are critically needed. Brown adipose tissue (BAT), a major source of heat production, possesses significant energy-dissipating capacity and therefore represents a promising target to use in combating these diseases. Recently, I discovered a novel link between circadian rhythm and thermogenic stress in the control of the conserved, calorie-burning functions of BAT. Circadian and thermogenic signaling to BAT incorporates blood-borne hormonal and nutrient cues with direct neuronal input. Yet how these responses coordinately shape BAT energy-expending potential through the regulation of cell surface receptors, metabolic enzymes, and transcriptional effectors is still not understood. My primary goal is to investigate this previously unappreciated network of crosstalk that allows mammals to effectively orchestrate daily rhythms in BAT metabolism, while maintaining their ability to adapt to abrupt changes in energy demand. My group will address this question using gain and loss-of-function in vitro and in vivo studies, newly-generated mouse models, customized physiological phenotyping, and cutting-edge advances in next generation RNA sequencing and mass spectrometry. Preliminary, small-scale validations of our methodologies have already yielded a number of novel candidates that may drive key facets of BAT metabolism. Additionally, we will extend our circadian and thermogenic studies into humans to evaluate the translational potential. Our results will advance the fundamental understanding of how daily oscillations in bioenergetic networks establish a framework for the anticipation of and adaptation to environmental challenges. Importantly, we expect that these mechanistic insights will reveal pharmacological targets through which we can unlock evolutionary constraints and harness the energy-expending potential of BAT for the prevention and treatment of obesity and diabetes.


year authors and title journal last update
List of publications.
2018 Elahu G. Sustarsic, Tao Ma, Matthew D. Lynes, Michael Larsen, Iuliia Karavaeva, Jesper F. Havelund, Carsten H. Nielsen, Mark P. Jedrychowski, Marta Moreno-Torres, Morten Lundh, Kaja Plucinska, Naja Z. Jespersen, Trisha J. Grevengoed, Barbara Kramar, Julia Peics, Jakob B. Hansen, Farnaz Shamsi, Isabel Forss, Ditte Neess, Susanne Keipert, Jianing Wang, Katharina Stohlmann, Ivan Brandslund, Cramer Christensen, Marit E. Jørgensen, Allan Linneberg, Oluf Pedersen, Michael A. Kiebish, Klaus Qvortrup, Xianlin Han, Bente Klarlund Pedersen, Martin Jastroch, Susanne Mandrup, Andreas Kjær, Steven P. Gygi, Torben Hansen, Matthew P. Gillum, Niels Grarup, Brice Emanuelli, Søren Nielsen, Camilla Scheele, Yu-Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
published pages: , ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.05.003
Cell Metabolism 2019-05-29

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