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aCROBAT SIGNED

Circadian Regulation Of Brown Adipose Thermogenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 aCROBAT project word cloud

Explore the words cloud of the aCROBAT project. It provides you a very rough idea of what is the project "aCROBAT" about.

treatment    network    mammals    rhythm    validations    spectrometry    bioenergetic    enzymes    physiological    insights    input    primary    abrupt    reached    heat    blood    newly    vitro    coordinately    unappreciated    brown    pandemic    link    phenotyping    dissipating    oscillations    diseases    sequencing    cutting    tissue    surface    daily    cues    possesses    humans    circadian    source    discovered    metabolism    customized    adapt    gain    edge    facets    previously    receptors    shape    expending    fundamental    regulation    networks    adipose    maintaining    question    therapeutic    strategies    combating    conserved    small    group    drive    metabolic    nutrient    unlock    framework    models    pharmacological    demand    thermogenic    borne    extend    proportions    harness    mechanistic    orchestrate    energy    candidates    transcriptional    functions    rhythms    cell    anticipation    function    preliminary    bat    neuronal    diabetes    incorporates    critically    burning    signaling    vivo    environmental    mass    crosstalk    constraints    prevention    capacity    direct    effectors    hormonal    obesity    rna    stress    evolutionary    translational    yielded    generation    additionally    calorie    reveal    mouse   

Project "aCROBAT" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙497˙007 €
 EC max contribution 1˙497˙007 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙497˙007.00

Map

 Project objective

Obesity and diabetes have reached pandemic proportions and new therapeutic strategies are critically needed. Brown adipose tissue (BAT), a major source of heat production, possesses significant energy-dissipating capacity and therefore represents a promising target to use in combating these diseases. Recently, I discovered a novel link between circadian rhythm and thermogenic stress in the control of the conserved, calorie-burning functions of BAT. Circadian and thermogenic signaling to BAT incorporates blood-borne hormonal and nutrient cues with direct neuronal input. Yet how these responses coordinately shape BAT energy-expending potential through the regulation of cell surface receptors, metabolic enzymes, and transcriptional effectors is still not understood. My primary goal is to investigate this previously unappreciated network of crosstalk that allows mammals to effectively orchestrate daily rhythms in BAT metabolism, while maintaining their ability to adapt to abrupt changes in energy demand. My group will address this question using gain and loss-of-function in vitro and in vivo studies, newly-generated mouse models, customized physiological phenotyping, and cutting-edge advances in next generation RNA sequencing and mass spectrometry. Preliminary, small-scale validations of our methodologies have already yielded a number of novel candidates that may drive key facets of BAT metabolism. Additionally, we will extend our circadian and thermogenic studies into humans to evaluate the translational potential. Our results will advance the fundamental understanding of how daily oscillations in bioenergetic networks establish a framework for the anticipation of and adaptation to environmental challenges. Importantly, we expect that these mechanistic insights will reveal pharmacological targets through which we can unlock evolutionary constraints and harness the energy-expending potential of BAT for the prevention and treatment of obesity and diabetes.

 Publications

year authors and title journal last update
List of publications.
2018 Elahu G. Sustarsic, Tao Ma, Matthew D. Lynes, Michael Larsen, Iuliia Karavaeva, Jesper F. Havelund, Carsten H. Nielsen, Mark P. Jedrychowski, Marta Moreno-Torres, Morten Lundh, Kaja Plucinska, Naja Z. Jespersen, Trisha J. Grevengoed, Barbara Kramar, Julia Peics, Jakob B. Hansen, Farnaz Shamsi, Isabel Forss, Ditte Neess, Susanne Keipert, Jianing Wang, Katharina Stohlmann, Ivan Brandslund, Cramer Christensen, Marit E. Jørgensen, Allan Linneberg, Oluf Pedersen, Michael A. Kiebish, Klaus Qvortrup, Xianlin Han, Bente Klarlund Pedersen, Martin Jastroch, Susanne Mandrup, Andreas Kjær, Steven P. Gygi, Torben Hansen, Matthew P. Gillum, Niels Grarup, Brice Emanuelli, Søren Nielsen, Camilla Scheele, Yu-Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
published pages: , ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.05.003
Cell Metabolism 2019-05-29

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