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TOLLerant SIGNED

Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TOLLerant" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA 

Organization address
address: PIAZZA DELL'ATENEO NUOVO 1
city: MILANO
postcode: 20126
website: www.unimib.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙122˙539 €
 EC max contribution 3˙122˙539 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme /MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) coordinator 516˙122.00
2    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II. IT (NAPOLI) participant 516˙122.00
3    KEMIJSKI INSTITUT SI (LJUBLJANA) participant 469˙995.00
4    VIB BE (ZWIJNAARDE - GENT) participant 250˙560.00
5    UNIVERSITAET BIELEFELD DE (BIELEFELD) participant 249˙216.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 247˙872.00
7    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) participant 247˙872.00
8    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) participant 247˙872.00
9    DIOMUNE SL ES (MADRID) participant 247˙872.00
10    LOFARMA S.P.A. IT (MILAN) participant 129˙030.00

Mappa

 Project objective

Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natural compounds and nanoparticles that interact selectively with some components (mainly MD-2 and CD14) of the TRL4 recognition system. TLR4 is an emerging molecular target related to an impressively broad spectrum of modern day disorders still lacking specific pharmacological treatment. These include autoimmune disorders, chronic inflammations, allergies, asthma, infectious and CNS diseases and cancer. The short-term scientific objective is to develop novel, non-toxic, synthetic and natural TLR4 modulators (agonists or antagonists) and to assess their therapeutic potential on animal models of TLR4-related acute and chronic pathologies that still lack efficient pharmacological treatment. The long-term scientific objective is to develop a new generation of innovative, TLR4-based therapeutics, to be used as vaccine adjuvants, anti-sepsis agents, and anti-inflammatory agents to treat chronic inflammations (allergy, asthma). The training programme will provide Early Stage Researchers (ESR) with broad competences, experience and skills in the cutting-edge, inter-disciplinary research in the field of chemical biology related to the molecular mechanisms of innate immunity and inflammation. During the training, the young researchers will be supported by senior scientists to cultivate their scientific, entrepreneurial and inter-cultural mindset. The non-academic sector will be committed to provide ESRs with entrepreneurship and company management skills, in order to enhance their employability by the private sector or even to motivate them to create own start-up companies.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "TOLLERANT" are provided by the European Opendata Portal: CORDIS opendata.

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