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SCIENCE SIGNED

Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SCIENCE" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://stemcellscience.dk/
 Total cost 5˙998˙882 €
 EC max contribution 5˙998˙882 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-single-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 3˙309˙862.00
2    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 670˙625.00
3    CARDIOLOGICUM HAMBURG DE (HAMBURG) participant 423˙750.00
4    UNIVERZITETNI KLINICNI CENTER LJUBLJANA SI (LJUBLJANA) participant 423˙125.00
5    SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH PL (KATOWICE) participant 416˙000.00
6    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 321˙875.00
7    TERUMO BCT EUROPE NV BE (ZAVENTEM) participant 232˙083.00
8    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 143˙750.00
9    WILLIAM COOK EUROPE ApS DK (BJAEVERSKOV) participant 57˙812.00

Map

 Project objective

Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)

With more than 17 million deaths worldwide each year, ischemic heart disease (IHD) caused by coronary artery disease is the most common cause of death and a major cause of hospital admissions in industrialised countries. IHD caused over four million deaths in Europe in the year 2012 constituting 47% of all deaths. Today IHD is the main cause of death among women throughout Europe and the main cause of death among men in all but six European countries.

Conventional therapies have reduced mortality of IHD significantly, but have left an increasing number of patients with chronic IHD and/or heart failure without further treatment options. An increasing morbidity rate of this nature in an ageing population is a huge burden for society.

The overall aim of the SCIENCE project is to implement an effective stem cell-based therapy with allogeneic adipose derived stromal cells to improve myocardial function in patients with ischemic heart disease and heart failure. This goal will be achieved by conducting a multicentre clinical trial in a strong consortium of experienced international scientists and experts as well as significant representatives of the biomedical industry within translational medicine and a close collaboration with relevant authorities.

The consortium will ensure feasibility of treatment by simplifying and rationalising cell production and distribution using state-of-the art manufacturing technology that makes cell therapy a realistic option for clinical practise. The consortium expects the SCIENCE project to pave the way for future approval of this treatment by national authorities throughout Europe as the standard form of care for patients with ischemic heart disease and heart failure.

This concept will establish a new platform for growth and consolidation of innovative small and medium-size companies within stem cell research and development. Such a platform will ease implementati

 Deliverables

List of deliverables.
IMP production final Other 2020-04-07 19:25:52
Clinical databases Demonstrators, pilots, prototypes 2020-04-07 19:25:51
First patient treated Other 2020-04-07 19:25:51
Training logs Documents, reports 2020-04-07 19:25:51
Website Websites, patent fillings, videos etc. 2020-04-07 19:25:51
Clinical trial kick-off Other 2020-04-07 19:25:51
All approvals package Documents, reports 2020-04-07 19:25:51
Production initiated Demonstrators, pilots, prototypes 2020-04-07 19:25:51
Preliminary cost-effectiveness analysis Documents, reports 2020-04-07 19:25:51
Qualification of production facility Documents, reports 2020-04-07 19:25:51

Take a look to the deliverables list in detail:  detailed list of SCIENCE deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Francisco Fernández-Avilés, Ricardo Sanz-Ruiz, Andreu M. Climent, Lina Badimon, Roberto Bolli, Dominique Charron, Valentin Fuster, Stefan Janssens, Jens Kastrup, Hyo-Soo Kim, Thomas F. Lüscher, John F. Martin, Philippe Menasché, Fausto J. Pinto, Robert D. Simari, Gregg W. Stone, Andre Terzic, James T. Willerson, Joseph C. Wu
Global Overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Recommendations
published pages: 199-201, ISSN: 0009-7330, DOI: 10.1161/circresaha.117.312099
Circulation Research 122/2 2020-04-07
2019 Christina Paitazoglou, Martin W. Bergmann, Bojan Vrtovec, Steven A.J. Chamuleau, Bas van Klarenbosch, Wojtek Wojakowski, Aleksandra Michalewska-Włudarczyk, Mariann Gyöngyösi, Annette Ekblond, Mandana Haack-Sørensen, Kai Jaquet, Karsten Vrangbaek, Jens Kastrup
Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)
published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1412
European Journal of Heart Failure 2020-04-07
2018 Mandana Haack-Sørensen, Morten Juhl, Bjarke Follin, Rebekka Harary Søndergaard, Maria Kirchhoff, Jens Kastrup, Annette Ekblond
Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate
published pages: 293-300, ISSN: 0036-5513, DOI: 10.1080/00365513.2018.1462082
Scandinavian Journal of Clinical and Laboratory Investigation 78/4 2020-04-07
2016 Mariann Gyöngyösi, Wojciech Wojakowski, Eliano P. Navarese, Lemuel À. Moye
Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies
published pages: 1254-1263, ISSN: 0009-7330, DOI: 10.1161/circresaha.115.307347
Circulation Research 118/8 2020-04-07
2017 Abbas Ali Qayyum, Kamal Preet Kaur, Anders Bruun Mathiasen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup
Influence of patient related factors on number of mesenchymal stromal cells reached after in vitro culture expansion for clinical treatment
published pages: 541-548, ISSN: 0036-5513, DOI: 10.1080/00365513.2017.1354258
Scandinavian Journal of Clinical and Laboratory Investigation 77/7 2020-04-07
2017 Francisco Fernández-Avilés, Ricardo Sanz-Ruiz, Andreu M. Climent, Lina Badimon, Roberto Bolli, Dominique Charron, Valentin Fuster, Stefan Janssens, Jens Kastrup, Hyo-Soo Kim, Thomas F. Lüscher, John F. Martin, Philippe Menasché, Robert D. Simari, Gregg W. Stone, Andre Terzic, James T. Willerson, Joseph C. Wu, Francisco Fernández-Avilés, Andre Terzic, Lina Badimon, Kathleen Broughton, Darcy L
Global position paper on cardiovascular regenerative medicine
published pages: 2532-2546, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx248
European Heart Journal 38/33 2020-04-07
2017 Jozef Bartunek, Wojtek Wojakowski
Intracoronary autologous bone marrow cell transfer after acute myocardial infarction: abort and refocus
published pages: 2944-2947, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx300
European Heart Journal 38/39 2020-04-07
2017 Jens Kastrup, Morten Schou, Ida Gustafsson, Olav W. Nielsen, Rasmus Møgelvang, Klaus F. Kofoed, Charlotte Kragelund, Jens Dahlgaard Hove, Andreas Fabricius-Bjerre, Merete Heitman, Mandana Haack-Sørensen, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Annette Ekblond
Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study
published pages: 1-8, ISSN: 1687-966X, DOI: 10.1155/2017/8506370
Stem Cells International 2017 2020-04-07
2016 Mariusz Z. Ratajczak, Kamila Bujko, Wojciech Wojakowski
Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies
published pages: 879-890, ISSN: 1897-9483, DOI: 10.20452/pamw.3644
Polish Archives of Internal Medicine 126/11 2020-04-07
2017 Jens Kastrup, Mandana Haack-Sørensen, Morten Juhl, Rebekka Harary Søndergaard, Bjarke Follin, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Helle Bruunsgaard, Annette Ekblond
Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure-A Safety Study
published pages: 1963-1971, ISSN: 2157-6564, DOI: 10.1002/sctm.17-0040
STEM CELLS Translational Medicine 6/11 2020-04-07

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