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NANOFACTURING

The Development of Medium- and Large-Scale Sustainable Manufacturing Process Platforms for Clinically Compliant Solid Core Nanopharmaceuticals

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NANOFACTURING" data sheet

The following table provides information about the project.

Coordinator
MIDATECH PHARMA ESPANA SL 

Organization address
address: PARQUE TECNOLOGICO DE BIZKAIA EDIFICIO 800 2A PLANTA
city: DERIO
postcode: 48160
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://nanofacturing.eu/
 Total cost 8˙758˙519 €
 EC max contribution 7˙898˙781 € (90%)
 Programme 1. H2020-EU.2.1.2.1. (Developing next generation nanomaterials, nanodevices and nanosystems)
 Code Call H2020-NMP-PILOTS-2014
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-02-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MIDATECH PHARMA ESPANA SL ES (DERIO) coordinator 2˙516˙593.00
2    CENTRE FOR PROCESS INNOVATION LIMITED LBG UK (REDCAR CLEVELAND) participant 2˙080˙420.00
3    MIDATECH LTD UK (CARDIFF) participant 866˙958.00
4    GALCHIMIA SA ES (O PINO A CORUNA) participant 675˙553.00
5    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 612˙921.00
6    PROCHIMIA SURFACES SP. Z O.O. PL (SOPOT) participant 472˙875.00
7    LGAI TECHNOLOGICAL CENTER SA ES (CERDANYOLA DEL VALLES BARCELONA) participant 409˙708.00
8    "INSTITUTO TUMORI ""GIOVANNI PAOLO II""" IT (BARI) participant 187˙131.00
9    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) participant 76˙618.00
10    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 0.00

Map

 Project objective

A number of nanomedicine formulations have enabled, or been shown to hold considerable potential for enabling more effective and less toxic therapeutic interventions. However, progress to date in translating these initiatives to commercial success has been limited. One of the main reasons for this bottleneck is due to the inability of researchers and stakeholders to manufacture batches of the nanomedicine product at the required scale and according to Good Manufacturing Practice (GMP) requirements. The NANOFACTURING project will focus on - facilitating access to required infrastructures and expertise - creating GMP pilot lines for up-scaling manufacturing - addressing the current developmental and production gaps - taking nanomaterials already successfully produced at proof-of-concept/milligram levels and facilitating their scale-up to sub-kilogram quantities - providing large-scale and GMP production for clinical trials and nanomedicine translation. The NANOFACTURING project, through a consortium of 9 partners, will develop the synthetic processes, process control methods, analytical assays for QA/QC, functional specifications, and best practices, interfacing existing R&D centres of excellence, transfer organisations and private GMP manufacturing facilities (including SMEs) to ensure efficient translation from discovery through to first in man, proof-of-concept studies and beyond to Phase III according to industrial and regulatory standards. Specifically, the NANOFACTURING project aims to create a platform process for early, mid- and large-scale manufacturing of glycan-coated gold nanoparticles (GNPs), a widely researched and developed class of self-forming nanoparticles. The ability to engineer new nanopharmaceuticals based on this patent protected platform technology, developed by Midatech Biogune S.L. (Project Coordinator), will have inherent advantages over existing treatments for multiple therapeutic areas.

 Deliverables

List of deliverables.
Final project report Documents, reports 2019-11-22 17:48:27
Updated dissemination and exploitation plan Documents, reports 2019-11-22 17:48:26
NANOFACTURING logo, brochure and leaflets Documents, reports 2019-11-22 17:48:26
Launch of NANOFACTURING Website Websites, patent fillings, videos etc. 2019-11-22 17:48:26
Outline dissemination plan Documents, reports 2019-11-22 17:48:26

Take a look to the deliverables list in detail:  detailed list of NANOFACTURING deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 V. Castagnola, W. Zhao, L. Boselli, M. C. Lo Giudice, F. Meder, E. Polo, K. R. Paton, C. Backes, J. N. Coleman, K. A. Dawson
Biological recognition of graphene nanoflakes
published pages: 1577 (2018), ISSN: 2041-1723, DOI: 10.1038/s41467-018-04009-x
Nature Communications 9/1 2019-11-22
2017 Laura Talamini, Martina B. Violatto, Qi Cai, Marco P. Monopoli, Karsten Kantner, Željka Krpetić, André Perez-Potti, Jennifer Cookman, David Garry, Camila P. Silveira, Luca Boselli, Beatriz Pelaz, Tommaso Serchi, Sébastien Cambier, Arno C. Gutleb, Neus Feliu, Yan Yan, Mario Salmona, Wolfgang J. Parak, Kenneth A. Dawson, Paolo Bigini
Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles
published pages: 5519-5529, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b00497
ACS Nano 11/6 2019-11-22
2019 Fatima Alnasser, Valentina Castagnola, Luca Boselli, Margarita Esquivel-Gaon, Esen Efeoglu, Jennifer McIntyre, Hugh J. Byrne, Kenneth A. Dawson
Graphene Nanoflake Uptake Mediated by Scavenger Receptors
published pages: 1260-1268, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b04820
Nano Letters 19/2 2019-11-22
2017 Luca Boselli, Ester Polo, Valentina Castagnola, Kenneth A. Dawson
Regimes of Biomolecular Ultrasmall Nanoparticle Interactions
published pages: 4279-4282, ISSN: 0044-8249, DOI: 10.1002/ange.201700343
Angewandte Chemie 129/15 2019-11-22
2017 V. Castagnola, J. Cookman, J. M. de Araújo, E. Polo, Q. Cai, C. P. Silveira, Ž. Krpetić, Y. Yan, L. Boselli, K. A. Dawson
Towards a classification strategy for complex nanostructures
published pages: 187-198, ISSN: 2055-6756, DOI: 10.1039/C6NH00219F
Nanoscale Horizons 2/4 2019-11-22
2017 Riccardo Balzaretti, Fabian Meder, Marco P. Monopoli, Luca Boselli, Ilaria Armenia, Loredano Pollegioni, Giovanni Bernardini, Rosalba Gornati
Synthesis, characterization and programmable toxicity of iron oxide nanoparticles conjugated with d -amino acid oxidase
published pages: 1439-1442, ISSN: 2046-2069, DOI: 10.1039/c6ra25349k
RSC Advances 7/3 2019-11-22
2017 Zhi Luo, Jing Hou, Laure Menin, Quy Khac Ong, Francesco Stellacci
Evolution of the Ligand Shell Morphology during Ligand Exchange Reactions on Gold Nanoparticles
published pages: 13521-13525, ISSN: 1433-7851, DOI: 10.1002/anie.201708190
Angewandte Chemie International Edition 56/43 2019-11-22
2017 Quy Ong, Zhi Luo, Francesco Stellacci
Characterization of Ligand Shell for Mixed-Ligand Coated Gold Nanoparticles
published pages: 1911-1919, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00165
Accounts of Chemical Research 50/8 2019-11-22
2016 Ahmet Bekdemir, Francesco Stellacci
A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles
published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms13121
Nature Communications 7/1 2019-11-22
2016 Kristof Zarschler, Louise Rocks, Nadia Licciardello, Luca Boselli, Ester Polo, Karina Pombo Garcia, Luisa De Cola, Holger Stephan, Kenneth A. Dawson
Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications
published pages: 1663-1701, ISSN: 1549-9634, DOI: 10.1016/j.nano.2016.02.019
Nanomedicine: Nanotechnology, Biology and Medicine 12/6 2019-11-22

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The information about "NANOFACTURING" are provided by the European Opendata Portal: CORDIS opendata.

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