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MEMCIRCUIT SIGNED

Deconstruction of a neural circuit for working memory: hubs, coding mechanisms, and signal routing

Total Cost €

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EC-Contrib. €

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Partnership

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 MEMCIRCUIT project word cloud

Explore the words cloud of the MEMCIRCUIT project. It provides you a very rough idea of what is the project "MEMCIRCUIT" about.

neural    suggest    network    formulate    persistent    animals    optogenetic    difference    pivotal    matching    fundamental    tools    shared    flow    interactions    neuronal    data    threshold    rodents    coding    species    mice    cell    auditory    performing    unprecedented    contribution    dissociation    sensory    memory    projection    innovative    lines    human    basis    mappings    cortex    mnemonic    neuroimaging    points    sites    record    reflexive    contested    synaptic    previously    goals    central    compare    cellular    circuit    millisecond    stimulus    animal    integrating    model    precise    questions    prefrontal    fingerprints    distributed    neurosurgical    single    behavioural    electrophysiology    dissect    cross    disrupt    humans    regional    cognition    provides    function    first    whereas    patients    recordings    spiking    mechanisms    critical    governed    cognitive    sub    memorized    alternatively    hub    brain    recording    awake    working    split    stored    heavily    signals    principles    internal    disconnected    me    neurons    maintenance    storage    double    region    resolution   

Project "MEMCIRCUIT" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.simonjacob.de
 Total cost 1˙499˙989 €
 EC max contribution 1˙499˙989 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 1˙499˙989.00

Map

 Project objective

Working memory is the basis of cognition. It allows behaviour to be governed by internal goals rather than by reflexive stimulus-response mappings. The neural mechanisms of memory maintenance are heavily contested. Animal electrophysiology studies suggest a pivotal role of persistent spiking activity in single neurons of the prefrontal cortex, whereas human neuroimaging points to sub-threshold synaptic activity distributed across sensory cortex. This double dissociation of storage mechanisms and storage sites could result from the comparison of different recording methods, which measure distinct neuronal signals. Alternatively, there might be a fundamental difference between humans and animals. My key objective is to formulate general principles of working memory coding at the cellular and circuit level by integrating across previously disconnected lines of research. I will address two central questions. First, where and how is the memorized information stored? I will use an innovative approach to record large-scale single-unit activity from a cognitive (prefrontal) and a sensory (auditory) region in awake neurosurgical patients and directly compare the data to recordings from mice performing the same auditory working memory task. This will allow me to determine whether the mnemonic fingerprints are species-specific or shared across humans and rodents. Second, what neural pathways support the flow of information during working memory? Using the animal model, I will disrupt cross-regional interactions in the memory network with millisecond-precise, projection-specific optogenetic tools in order to dissect the contribution of each hub to memory storage and memory access. This project provides an unprecedented one-to-one matching of behavioural tasks and recording methods with single-cell and split-second resolution in humans and rodents. It represents a major step forward in understanding the cellular and circuit basis of a critical cognitive brain function.

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The information about "MEMCIRCUIT" are provided by the European Opendata Portal: CORDIS opendata.

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