PeroxiSystem SIGNED
Systematic exploration of peroxisomal structure and function
Total Cost €
0EC-Contrib. €
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Project "PeroxiSystem" data sheet
The following table provides information about the project.
| Coordinator |
WEIZMANN INSTITUTE OF SCIENCE
Organization address contact info |
| Coordinator Country | Israel [IL] |
| Project website | http://mayaschuldiner.wixsite.com/schuldinerlab/peroxisome-team-1 |
| Total cost | 2˙000˙000 € |
| EC max contribution | 2˙000˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | WEIZMANN INSTITUTE OF SCIENCE | IL (REHOVOT) | coordinator | 2˙000˙000.00 |
Map
Project objective
Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental questions remain open. For example, we do not know the entire proteome of peroxisomes, the extent of their metabolic functions, how peroxisomes change to meet cellular requirements or how they interact and communicate with other cellular organelles. In this proposal we suggest to employ our expertise and unique toolsets, successfully applied in the study of whole organelles, to shed new light on peroxisomes as a cellular unit – a PeroxiSystem. We propose to combine state-of-the art high content tools with mechanistic studies to uncover new peroxisomal proteins under a variety of growth conditions (Aim1), map the functions of unstudied peroxisomal proteins using both systematic and hypothesis driven approaches (Aim 2) and unravel how peroxisomes communicate with other organelles (Aim 3). To perform these studies we will build on expertise attained during an ERC StG: combining high throughput genetic manipulations of yeast libraries alongside high content screens. Importantly, we will try to bridge the knowledge gap in peroxisomal biology by creating new tools that can be applied to this unique organelle. Our findings should make an important step towards an unprecedented, thorough and multifaceted understanding of peroxisomes, their cellular geography and roles as well as their regulation when presented with various metabolic conditions. More broadly, the approaches presented here can be easily applied to study any organelle of choice, thus providing a conceptual framework in the study of cell biology.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner Coming together to define membrane contact sites published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09253-3 |
Nature Communications 10/1 | 2020-04-15 |
| 2019 |
Uri Weill, Nir Cohen, Amir Fadel, Shifra Benâ€Dor, Maya Schuldiner Protein Topology Prediction Algorithms Systematically Investigated in the Yeast Saccharomyces cerevisiae published pages: 1800252, ISSN: 0265-9247, DOI: 10.1002/bies.201800252 |
BioEssays 41/8 | 2020-04-15 |
| 2017 |
Maya Schuldiner, Einat Zalckvar Incredibly close—A newly identified peroxisome–ER contact site in humans published pages: 287-289, ISSN: 0021-9525, DOI: 10.1083/jcb.201701072 |
Journal of Cell Biology 216/2 | 2020-04-15 |
| 2019 |
Uri Weill, Gat Krieger, Zohar Avihou, Ron Milo, Maya Schuldiner, Dan Davidi Assessment of GFP Tag Position on Protein Localization and Growth Fitness in Yeast published pages: 636-641, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.12.004 |
Journal of Molecular Biology 431/3 | 2020-04-15 |
| 2019 |
Yury S. Bykov, Nir Cohen, Natalia Gabrielli, Hetty Manenschijn, Sonja Welsch, Petr Chlanda, Wanda Kukulski, Kiran R. Patil, Maya Schuldiner, John A.G. Briggs High-throughput ultrastructure screening using electron microscopy and fluorescent barcoding published pages: 2797-2811, ISSN: 0021-9525, DOI: 10.1083/jcb.201812081 |
Journal of Cell Biology 218/8 | 2020-04-15 |
| 2018 |
Shiran Gabay-Maskit, Maya Schuldiner, Einat Zalckvar Validation of a yeast malate dehydrogenase 2 (Mdh2) antibody tested for use in western blots published pages: 130, ISSN: 2046-1402, DOI: 10.12688/f1000research.13396.1 |
F1000Research 7 | 2019-06-05 |
| 2018 |
Inês Gomes Castro, Maya Schuldiner, Einat Zalckvar Mind the Organelle Gap – Peroxisome Contact Sites in Disease published pages: 199-210, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2018.01.001 |
Trends in Biochemical Sciences 43/3 | 2019-06-05 |
| 2018 |
Silvia G. Chuartzman, Maya Schuldiner Database for HIgh Throughput Screening hits (dHITS): A simple tool to retrieve gene specific phenotypes from systematic screens done in yeast published pages: , ISSN: 0749-503X, DOI: 10.1002/yea.3312 |
Yeast | 2019-06-05 |
| 2017 |
Justyna P. Wróblewska, Luis Daniel Cruz-Zaragoza, Wei Yuan, Andreas Schummer, Silvia G. Chuartzman, Rinse de Boer, Silke Oeljeklaus, Maya Schuldiner, Einat Zalckvar, Bettina Warscheid, Ralf Erdmann, Ida J. van der Klei Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins published pages: 1656-1667, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2017.05.021 |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864/10 | 2019-06-05 |
| 2018 |
Eden Yifrach, Sven Fischer, Silke Oeljeklaus, Maya Schuldiner, Einat Zalckvar, Bettina Warscheid Defining the Mammalian Peroxisomal Proteome published pages: 47-66, ISSN: 0306-0225, DOI: 10.1007/978-981-13-2233-4_2 |
Subcellular Biochememistry | 2019-06-05 |
| 2018 |
Uri Weill, Ido Yofe, Ehud Sass, Bram Stynen, Dan Davidi, Janani Natarajan, Reut Ben-Menachem, Zohar Avihou, Omer Goldman, Nofar Harpaz, Silvia Chuartzman, Kiril Kniazev, Barbara Knoblach, Janina Laborenz, Felix Boos, Jacqueline Kowarzyk, Shifra Ben-Dor, Einat Zalckvar, Johannes M. Herrmann, Richard A. Rachubinski, Ophry Pines, Doron Rapaport, Stephen W. Michnick, Emmanuel D. Levy, Maya Schuldiner Genome-wide SWAp-Tag yeast libraries for proteome exploration published pages: 617-622, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0044-9 |
Nature Methods 15/8 | 2019-06-05 |
| 2018 |
Nadav Shai, Eden Yifrach, Carlo W. T. van Roermund, Nir Cohen, Chen Bibi, Lodewijk IJlst, Laetitia Cavellini, Julie Meurisse, Ramona Schuster, Lior Zada, Muriel C. Mari, Fulvio M. Reggiori, Adam L. Hughes, Mafalda Escobar-Henriques, Mickael M. Cohen, Hans R. Waterham, Ronald J. A. Wanders, Maya Schuldiner, Einat Zalckvar Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03957-8 |
Nature Communications 9/1 | 2019-06-05 |
| 2017 |
Noa Dahan, Maya Schuldiner, Einat Zalckvar Peroxisome Mini-Libraries: Systematic Approaches to Study Peroxisomes Made Easy. published pages: 305-318, ISSN: , DOI: 10.1007/978-1-4939-6937-1_28 |
Methods Mol Biol | 2019-06-05 |
| 2016 |
Eden Yifrach, Silvia G. Chuartzman, Noa Dahan, Shiran Maskit, Lior Zada, Uri Weill, Ido Yofe, Tsviya Olender, Maya Schuldiner, Einat Zalckvar Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor published pages: jcs.195255, ISSN: 0021-9533, DOI: 10.1242/jcs.195255 |
Journal of Cell Science | 2019-06-05 |
| 2016 |
Ido Yofe, Uri Weill, Matthias Meurer, Silvia Chuartzman, Einat Zalckvar, Omer Goldman, Shifra Ben-Dor, Conny Schütze, Nils Wiedemann, Michael Knop, Anton Khmelinskii, Maya Schuldiner One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy published pages: 371-378, ISSN: 1548-7091, DOI: 10.1038/nmeth.3795 |
Nature Methods 13/4 | 2019-06-05 |
| 2016 |
Michal Eisenberg-Bord, Nadav Shai, Maya Schuldiner, Maria Bohnert A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites published pages: 395-409, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.10.022 |
Developmental Cell 39/4 | 2019-06-05 |
| 2015 |
Maya Schuldiner, Einat Zalckvar Peroxisystem: Harnessing systems cell biology to study peroxisomes published pages: 89-97, ISSN: 0248-4900, DOI: 10.1111/boc.201400091 |
Biology of the Cell 107/4 | 2019-06-05 |
| 2016 |
Nadav Shai, Maya Schuldiner, Einat Zalckvar No peroxisome is an island — Peroxisome contact sites published pages: 1061-1069, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2015.09.016 |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863/5 | 2019-06-05 |
| 2017 |
Ido Yofe, Kareem Soliman, Silvia G. Chuartzman, Bruce Morgan, Uri Weill, Eden Yifrach, Tobias P. Dick, Sara J. Cooper, Christer S. Ejsing, Maya Schuldiner, Einat Zalckvar, Sven Thoms Pex35 is a regulator of peroxisome abundance published pages: 791-804, ISSN: 0021-9533, DOI: 10.1242/jcs.187914 |
Journal of Cell Science 130/4 | 2019-06-05 |
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