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PeroxiSystem SIGNED

Systematic exploration of peroxisomal structure and function

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EC-Contrib. €

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Project "PeroxiSystem" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://mayaschuldiner.wixsite.com/schuldinerlab/peroxisome-team-1
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

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 Project objective

Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental questions remain open. For example, we do not know the entire proteome of peroxisomes, the extent of their metabolic functions, how peroxisomes change to meet cellular requirements or how they interact and communicate with other cellular organelles. In this proposal we suggest to employ our expertise and unique toolsets, successfully applied in the study of whole organelles, to shed new light on peroxisomes as a cellular unit – a PeroxiSystem. We propose to combine state-of-the art high content tools with mechanistic studies to uncover new peroxisomal proteins under a variety of growth conditions (Aim1), map the functions of unstudied peroxisomal proteins using both systematic and hypothesis driven approaches (Aim 2) and unravel how peroxisomes communicate with other organelles (Aim 3). To perform these studies we will build on expertise attained during an ERC StG: combining high throughput genetic manipulations of yeast libraries alongside high content screens. Importantly, we will try to bridge the knowledge gap in peroxisomal biology by creating new tools that can be applied to this unique organelle. Our findings should make an important step towards an unprecedented, thorough and multifaceted understanding of peroxisomes, their cellular geography and roles as well as their regulation when presented with various metabolic conditions. More broadly, the approaches presented here can be easily applied to study any organelle of choice, thus providing a conceptual framework in the study of cell biology.

 Publications

year authors and title journal last update
List of publications.
2019 Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Coming together to define membrane contact sites
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09253-3
Nature Communications 10/1 2020-04-15
2019 Uri Weill, Nir Cohen, Amir Fadel, Shifra Ben‐Dor, Maya Schuldiner
Protein Topology Prediction Algorithms Systematically Investigated in the Yeast Saccharomyces cerevisiae
published pages: 1800252, ISSN: 0265-9247, DOI: 10.1002/bies.201800252
BioEssays 41/8 2020-04-15
2017 Maya Schuldiner, Einat Zalckvar
Incredibly close—A newly identified peroxisome–ER contact site in humans
published pages: 287-289, ISSN: 0021-9525, DOI: 10.1083/jcb.201701072
Journal of Cell Biology 216/2 2020-04-15
2019 Uri Weill, Gat Krieger, Zohar Avihou, Ron Milo, Maya Schuldiner, Dan Davidi
Assessment of GFP Tag Position on Protein Localization and Growth Fitness in Yeast
published pages: 636-641, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.12.004
Journal of Molecular Biology 431/3 2020-04-15
2019 Yury S. Bykov, Nir Cohen, Natalia Gabrielli, Hetty Manenschijn, Sonja Welsch, Petr Chlanda, Wanda Kukulski, Kiran R. Patil, Maya Schuldiner, John A.G. Briggs
High-throughput ultrastructure screening using electron microscopy and fluorescent barcoding
published pages: 2797-2811, ISSN: 0021-9525, DOI: 10.1083/jcb.201812081
Journal of Cell Biology 218/8 2020-04-15
2018 Shiran Gabay-Maskit, Maya Schuldiner, Einat Zalckvar
Validation of a yeast malate dehydrogenase 2 (Mdh2) antibody tested for use in western blots
published pages: 130, ISSN: 2046-1402, DOI: 10.12688/f1000research.13396.1
F1000Research 7 2019-06-05
2018 Inês Gomes Castro, Maya Schuldiner, Einat Zalckvar
Mind the Organelle Gap – Peroxisome Contact Sites in Disease
published pages: 199-210, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2018.01.001
Trends in Biochemical Sciences 43/3 2019-06-05
2018 Silvia G. Chuartzman, Maya Schuldiner
Database for HIgh Throughput Screening hits (dHITS): A simple tool to retrieve gene specific phenotypes from systematic screens done in yeast
published pages: , ISSN: 0749-503X, DOI: 10.1002/yea.3312
Yeast 2019-06-05
2017 Justyna P. Wróblewska, Luis Daniel Cruz-Zaragoza, Wei Yuan, Andreas Schummer, Silvia G. Chuartzman, Rinse de Boer, Silke Oeljeklaus, Maya Schuldiner, Einat Zalckvar, Bettina Warscheid, Ralf Erdmann, Ida J. van der Klei
Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins
published pages: 1656-1667, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2017.05.021
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864/10 2019-06-05
2018 Eden Yifrach, Sven Fischer, Silke Oeljeklaus, Maya Schuldiner, Einat Zalckvar, Bettina Warscheid
Defining the Mammalian Peroxisomal Proteome
published pages: 47-66, ISSN: 0306-0225, DOI: 10.1007/978-981-13-2233-4_2
Subcellular Biochememistry 2019-06-05
2018 Uri Weill, Ido Yofe, Ehud Sass, Bram Stynen, Dan Davidi, Janani Natarajan, Reut Ben-Menachem, Zohar Avihou, Omer Goldman, Nofar Harpaz, Silvia Chuartzman, Kiril Kniazev, Barbara Knoblach, Janina Laborenz, Felix Boos, Jacqueline Kowarzyk, Shifra Ben-Dor, Einat Zalckvar, Johannes M. Herrmann, Richard A. Rachubinski, Ophry Pines, Doron Rapaport, Stephen W. Michnick, Emmanuel D. Levy, Maya Schuldiner
Genome-wide SWAp-Tag yeast libraries for proteome exploration
published pages: 617-622, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0044-9
Nature Methods 15/8 2019-06-05
2018 Nadav Shai, Eden Yifrach, Carlo W. T. van Roermund, Nir Cohen, Chen Bibi, Lodewijk IJlst, Laetitia Cavellini, Julie Meurisse, Ramona Schuster, Lior Zada, Muriel C. Mari, Fulvio M. Reggiori, Adam L. Hughes, Mafalda Escobar-Henriques, Mickael M. Cohen, Hans R. Waterham, Ronald J. A. Wanders, Maya Schuldiner, Einat Zalckvar
Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03957-8
Nature Communications 9/1 2019-06-05
2017 Noa Dahan, Maya Schuldiner, Einat Zalckvar
Peroxisome Mini-Libraries: Systematic Approaches to Study Peroxisomes Made Easy.
published pages: 305-318, ISSN: , DOI: 10.1007/978-1-4939-6937-1_28
Methods Mol Biol 2019-06-05
2016 Eden Yifrach, Silvia G. Chuartzman, Noa Dahan, Shiran Maskit, Lior Zada, Uri Weill, Ido Yofe, Tsviya Olender, Maya Schuldiner, Einat Zalckvar
Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor
published pages: jcs.195255, ISSN: 0021-9533, DOI: 10.1242/jcs.195255
Journal of Cell Science 2019-06-05
2016 Ido Yofe, Uri Weill, Matthias Meurer, Silvia Chuartzman, Einat Zalckvar, Omer Goldman, Shifra Ben-Dor, Conny Schütze, Nils Wiedemann, Michael Knop, Anton Khmelinskii, Maya Schuldiner
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
published pages: 371-378, ISSN: 1548-7091, DOI: 10.1038/nmeth.3795
Nature Methods 13/4 2019-06-05
2016 Michal Eisenberg-Bord, Nadav Shai, Maya Schuldiner, Maria Bohnert
A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites
published pages: 395-409, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.10.022
Developmental Cell 39/4 2019-06-05
2015 Maya Schuldiner, Einat Zalckvar
Peroxisystem: Harnessing systems cell biology to study peroxisomes
published pages: 89-97, ISSN: 0248-4900, DOI: 10.1111/boc.201400091
Biology of the Cell 107/4 2019-06-05
2016 Nadav Shai, Maya Schuldiner, Einat Zalckvar
No peroxisome is an island — Peroxisome contact sites
published pages: 1061-1069, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2015.09.016
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863/5 2019-06-05
2017 Ido Yofe, Kareem Soliman, Silvia G. Chuartzman, Bruce Morgan, Uri Weill, Eden Yifrach, Tobias P. Dick, Sara J. Cooper, Christer S. Ejsing, Maya Schuldiner, Einat Zalckvar, Sven Thoms
Pex35 is a regulator of peroxisome abundance
published pages: 791-804, ISSN: 0021-9533, DOI: 10.1242/jcs.187914
Journal of Cell Science 130/4 2019-06-05

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