Explore the words cloud of the Clock Mechanics project. It provides you a very rough idea of what is the project "Clock Mechanics" about.
The following table provides information about the project.
UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙899˙549 €|
|EC max contribution||1˙899˙549 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2021-08-31|
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|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||1˙899˙549.00|
All forms of life adjust themselves to the daily rhythms of their environments using endogenous oscillators collectively referred to as circadian clocks. Peripheral and central body clocks exist, which both require extrinsic information (e.g. light or temperature changes) to keep in sync with the geophysical cycle (entrainment). In addition, intrinsic cues (e.g. activity levels) have been linked to clock entrainment. Recently, we could show that activation of proprioceptors is sufficient to entrain the central clock of the fruit fly Drosophila melanogaster. Proprioceptors are mechanosensors that monitor the positions, and relative movements, of an animal’s own body parts. The existence of proprioceptive entrainment pathways has significant implications; it implies that an animal’s ‘clock time’ is computed by integrating, and weighting, various external and internal conditions, suggesting the existence of external and internal time. Using Drosophila, I will investigate the relationship between mechanosensory and circadian systems in a dual, and bidirectional, approach. The project’s first aim is to dissect the neurobiological bases of proprioceptive clock entrainment (i) identifying the specific stimulus requirements for effective entrainment, (ii) determining its mechanosensory pathways and, in a combined computational and experimental strategy, (iii) quantifying the precise contributions of an animal’s activity to its sense of time. The project’s second aim, in turn, is to unravel the roles of the clock, and clock genes, for the function of mechanosensory systems. Previous studies have linked the clock to noise vulnerability in mammalian ears, and clock genes to regeneration in avian ears. Our own preliminary data reveal severe mechanosensory defects in flies mutant for core clock genes. I will use the Drosophila ear as a unifying model to analyse the specific roles of the clock, and clock genes, for the function of mechanotransducer systems.
|year||authors and title||journal||last update|
Gale, Jonathan E.
Jarman, Andrew P.
Albert, Joerg T.
Homeostatic maintenance and age-related functional decline in the Drosophila ear
published pages: NA, ISSN: , DOI: 10.1101/764670
Jason Somers, Ross E. F. Harper, Joerg T. Albert
How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems
published pages: , ISSN: 1662-5153, DOI: 10.3389/fnbeh.2018.00211
|Frontiers in Behavioral Neuroscience 12||2019-05-28|
Matthew P. Su, Marta AndrÃ©s, Nicholas Boyd-Gibbins, Jason Somers, Joerg T. Albert
Sex and species specific hearing mechanisms in mosquito flagellar ears
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06388-7
|Nature Communications 9/1||2019-05-28|
RossÂ E.F. Harper, Peter Dayan, JoergÂ T. Albert, Ralf Stanewsky
Sensory Conflict Disrupts Activity of the Drosophila Circadian Network
published pages: 1711-1718, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.10.029
|Cell Reports 17/7||2019-06-06|
Ross E. F. Harper, Maite Ogueta, Peter Dayan, Ralf Stanewsky, Joerg T. Albert
Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict
published pages: 423-432, ISSN: 0748-7304, DOI: 10.1177/0748730417724250
|Journal of Biological Rhythms 32/5||2019-06-06|
JoergÂ T. Albert, AndreiÂ S. Kozlov
Comparative Aspects of Hearing in Vertebrates and Insects with Antennal Ears
published pages: R1050-R1061, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.017
|Current Biology 26/20||2019-06-06|
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