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Clock Mechanics SIGNED

Mechanosensation and the circadian clock: a reciprocal analysis

Total Cost €


EC-Contrib. €






 Clock Mechanics project word cloud

Explore the words cloud of the Clock Mechanics project. It provides you a very rough idea of what is the project "Clock Mechanics" about.

implications    core    light    levels    turn    computed    sufficient    mechanosensors    severe    proprioceptive    daily    first    environments    fly    external    unifying    cycle    animal    extrinsic    relative    unravel    monitor    neurobiological    adjust    dissect    peripheral    clock    body    themselves    entrain    central    fruit    experimental    intrinsic    regeneration    keep    parts    weighting    entrainment    integrating    computational    temperature    ears    strategy    mammalian    function    exist    movements    defects    internal    bases    endogenous    suggesting    activation    dual    mechanotransducer    collectively    roles    drosophila    combined    quantifying    data    mechanosensory    precise    stimulus    clocks    life    genes    melanogaster    sync    forms    linked    model    all    preliminary    reveal    positions    sense    rhythms    avian    contributions    geophysical    relationship    vulnerability    noise    circadian    cues    bidirectional    ear    proprioceptors    mutant    flies    oscillators    existence    time    implies   

Project "Clock Mechanics" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙899˙549 €
 EC max contribution 1˙899˙549 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙899˙549.00


 Project objective

All forms of life adjust themselves to the daily rhythms of their environments using endogenous oscillators collectively referred to as circadian clocks. Peripheral and central body clocks exist, which both require extrinsic information (e.g. light or temperature changes) to keep in sync with the geophysical cycle (entrainment). In addition, intrinsic cues (e.g. activity levels) have been linked to clock entrainment. Recently, we could show that activation of proprioceptors is sufficient to entrain the central clock of the fruit fly Drosophila melanogaster. Proprioceptors are mechanosensors that monitor the positions, and relative movements, of an animal’s own body parts. The existence of proprioceptive entrainment pathways has significant implications; it implies that an animal’s ‘clock time’ is computed by integrating, and weighting, various external and internal conditions, suggesting the existence of external and internal time. Using Drosophila, I will investigate the relationship between mechanosensory and circadian systems in a dual, and bidirectional, approach. The project’s first aim is to dissect the neurobiological bases of proprioceptive clock entrainment (i) identifying the specific stimulus requirements for effective entrainment, (ii) determining its mechanosensory pathways and, in a combined computational and experimental strategy, (iii) quantifying the precise contributions of an animal’s activity to its sense of time. The project’s second aim, in turn, is to unravel the roles of the clock, and clock genes, for the function of mechanosensory systems. Previous studies have linked the clock to noise vulnerability in mammalian ears, and clock genes to regeneration in avian ears. Our own preliminary data reveal severe mechanosensory defects in flies mutant for core clock genes. I will use the Drosophila ear as a unifying model to analyse the specific roles of the clock, and clock genes, for the function of mechanotransducer systems.


year authors and title journal last update
List of publications.
2019 Keder, Alyona Tardieu, Camille Malong, Liza Filia, Anastasia Kashkenbayeva, Assel Gale, Jonathan E. Lovett, Mike Jarman, Andrew P. Albert, Joerg T.
Homeostatic maintenance and age-related functional decline in the Drosophila ear
published pages: NA, ISSN: , DOI: 10.1101/764670
bioRxiv NA 2020-04-15
2018 Jason Somers, Ross E. F. Harper, Joerg T. Albert
How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems
published pages: , ISSN: 1662-5153, DOI: 10.3389/fnbeh.2018.00211
Frontiers in Behavioral Neuroscience 12 2019-05-28
2018 Matthew P. Su, Marta Andrés, Nicholas Boyd-Gibbins, Jason Somers, Joerg T. Albert
Sex and species specific hearing mechanisms in mosquito flagellar ears
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06388-7
Nature Communications 9/1 2019-05-28
2016 Ross E.F. Harper, Peter Dayan, Joerg T. Albert, Ralf Stanewsky
Sensory Conflict Disrupts Activity of the Drosophila Circadian Network
published pages: 1711-1718, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.10.029
Cell Reports 17/7 2019-06-06
2017 Ross E. F. Harper, Maite Ogueta, Peter Dayan, Ralf Stanewsky, Joerg T. Albert
Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict
published pages: 423-432, ISSN: 0748-7304, DOI: 10.1177/0748730417724250
Journal of Biological Rhythms 32/5 2019-06-06
2016 Joerg T. Albert, Andrei S. Kozlov
Comparative Aspects of Hearing in Vertebrates and Insects with Antennal Ears
published pages: R1050-R1061, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.017
Current Biology 26/20 2019-06-06

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