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Clock Mechanics SIGNED

Mechanosensation and the circadian clock: a reciprocal analysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Clock Mechanics project word cloud

Explore the words cloud of the Clock Mechanics project. It provides you a very rough idea of what is the project "Clock Mechanics" about.

bases    combined    neurobiological    entrainment    extrinsic    vulnerability    themselves    movements    model    melanogaster    animal    quantifying    avian    flies    ear    sufficient    drosophila    geophysical    circadian    adjust    activation    contributions    cues    core    central    preliminary    implications    noise    reveal    exist    integrating    proprioceptors    life    parts    clocks    environments    levels    monitor    fly    mutant    forms    endogenous    ears    computational    internal    mechanosensors    entrain    precise    rhythms    clock    existence    light    temperature    stimulus    dual    cycle    positions    strategy    oscillators    computed    severe    collectively    data    daily    proprioceptive    turn    first    all    sense    body    mechanotransducer    mammalian    linked    intrinsic    function    unravel    relative    unifying    relationship    time    roles    genes    weighting    regeneration    dissect    experimental    implies    bidirectional    fruit    defects    suggesting    sync    external    peripheral    keep    mechanosensory   

Project "Clock Mechanics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙899˙549 €
 EC max contribution 1˙899˙549 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙899˙549.00

Map

 Project objective

All forms of life adjust themselves to the daily rhythms of their environments using endogenous oscillators collectively referred to as circadian clocks. Peripheral and central body clocks exist, which both require extrinsic information (e.g. light or temperature changes) to keep in sync with the geophysical cycle (entrainment). In addition, intrinsic cues (e.g. activity levels) have been linked to clock entrainment. Recently, we could show that activation of proprioceptors is sufficient to entrain the central clock of the fruit fly Drosophila melanogaster. Proprioceptors are mechanosensors that monitor the positions, and relative movements, of an animal’s own body parts. The existence of proprioceptive entrainment pathways has significant implications; it implies that an animal’s ‘clock time’ is computed by integrating, and weighting, various external and internal conditions, suggesting the existence of external and internal time. Using Drosophila, I will investigate the relationship between mechanosensory and circadian systems in a dual, and bidirectional, approach. The project’s first aim is to dissect the neurobiological bases of proprioceptive clock entrainment (i) identifying the specific stimulus requirements for effective entrainment, (ii) determining its mechanosensory pathways and, in a combined computational and experimental strategy, (iii) quantifying the precise contributions of an animal’s activity to its sense of time. The project’s second aim, in turn, is to unravel the roles of the clock, and clock genes, for the function of mechanosensory systems. Previous studies have linked the clock to noise vulnerability in mammalian ears, and clock genes to regeneration in avian ears. Our own preliminary data reveal severe mechanosensory defects in flies mutant for core clock genes. I will use the Drosophila ear as a unifying model to analyse the specific roles of the clock, and clock genes, for the function of mechanotransducer systems.

 Publications

year authors and title journal last update
List of publications.
2019 Keder, Alyona Tardieu, Camille Malong, Liza Filia, Anastasia Kashkenbayeva, Assel Gale, Jonathan E. Lovett, Mike Jarman, Andrew P. Albert, Joerg T.
Homeostatic maintenance and age-related functional decline in the Drosophila ear
published pages: NA, ISSN: , DOI: 10.1101/764670
bioRxiv NA 2020-04-15
2018 Jason Somers, Ross E. F. Harper, Joerg T. Albert
How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems
published pages: , ISSN: 1662-5153, DOI: 10.3389/fnbeh.2018.00211
Frontiers in Behavioral Neuroscience 12 2019-05-28
2018 Matthew P. Su, Marta Andrés, Nicholas Boyd-Gibbins, Jason Somers, Joerg T. Albert
Sex and species specific hearing mechanisms in mosquito flagellar ears
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06388-7
Nature Communications 9/1 2019-05-28
2016 Ross E.F. Harper, Peter Dayan, Joerg T. Albert, Ralf Stanewsky
Sensory Conflict Disrupts Activity of the Drosophila Circadian Network
published pages: 1711-1718, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.10.029
Cell Reports 17/7 2019-06-06
2017 Ross E. F. Harper, Maite Ogueta, Peter Dayan, Ralf Stanewsky, Joerg T. Albert
Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict
published pages: 423-432, ISSN: 0748-7304, DOI: 10.1177/0748730417724250
Journal of Biological Rhythms 32/5 2019-06-06
2016 Joerg T. Albert, Andrei S. Kozlov
Comparative Aspects of Hearing in Vertebrates and Insects with Antennal Ears
published pages: R1050-R1061, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.017
Current Biology 26/20 2019-06-06

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