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Sex differences in expression in the shared genome

Total Cost €


EC-Contrib. €






Project "SexDiff" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2019-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

Males and females in many animals are strikingly different in behaviour, physiology, shape and form. In humans, rates of ageing and disease incidence vary markedly between the sexes. Moreover, sex differences in response to medical therapies and treatments have recently become an area of major biomedical concern. Because there are very few sex-limited genes, sex differences are largely a product of contrasting gene expression patterns between males and females4. Despite their ubiquity and clear biomedical importance, the evolutionary causes of sex differences in gene expression remain essentially unknown and pose a fundamental problem for biologists: How do sex differences evolve given that the sexes largely share the same genome?

My research addresses this fundamental question using two approaches: (1) a data-driven, large-scale phylogenetic approach, and (2) an experimental manipulation of chromosome dose in Drosophila melanogaster. The results from this project will create comprehensive understanding of sex-specific gene regulation and evolution. This broad research has important implications for medical, developmental and evolutionary studies of sex differences and addresses a key aim, as identified by the European Commission, for research excellence in Horizon 2020.


year authors and title journal last update
List of publications.
2018 Rebecca Dean, Camille Hammer, Vanessa Higham, Damian K. Dowling
Masculinization of gene expression is associated with male quality in Drosophila melanogaster
published pages: 2736-2748, ISSN: 0014-3820, DOI: 10.1111/evo.13618
Evolution 72/12 2019-11-06
2017 Rebecca Dean, Alison E. Wright, Susan E. Marsh-Rollo, Bridget M. Nugent, Suzanne H. Alonzo, Judith E. Mank
Sperm competition shapes gene expression and sequence evolution in the ocellated wrasse
published pages: 505-518, ISSN: 0962-1083, DOI: 10.1111/mec.13919
Molecular Ecology 26/2 2019-11-06
2016 Rebecca Dean, Judith E. Mank
Tissue Specificity and Sex-Specific Regulatory Variation Permit the Evolution of Sex-Biased Gene Expression
published pages: E74-E84, ISSN: 0003-0147, DOI: 10.1086/687526
The American Naturalist 188/3 2019-11-06

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