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Tiny Functional Au Nanorods: Novel NIR-Photothermal Nanoprobes for Single-Molecule Tracking at Confined Cellular Environment

Total Cost €


EC-Contrib. €






 TiFuN project word cloud

Explore the words cloud of the TiFuN project. It provides you a very rough idea of what is the project "TiFuN" about.

fellow    property    utilize    surface    background    specificity    rods    synapses    photothermal    owing    tunable    neurotransmitter    technique    correlative    density    phi    dynamics    absorption    nanoprobe    optics    chemistry    toxicity    tool    bioconjugated    proteins    detection    molecule    nps    tackle    signal    lounis    ultrahigh    synapse    plasmon    interdisciplinary    individual    sensitivity    ratio    choquet    harvested    multicolor    window    exceptional    world    setup    size    integrin    combination    sources    regions    probes    biology    spr    limits    nanoprobes    expertise    brilliant    adhesion    length    core    laser    gold    cell    light    microscopy    tifun    lt    confined    neuroscience    needle    prof    protocol    nir    receptors    haystack    nm    electron    centered    domain    easily    photostability    np    centrifugation    neural    resonance    bioconjuagted    dgu    labeling    imaging    tiny    smaller    organelles    detected    nanoparticles    530    spectral    diameter    small    valuable    single    display    volume    gradient    nanorods    dr    group    cellular    subsequently    sites    elongated    nanochemistry   

Project "TiFuN" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Photothermal Imaging (PhI) is an absorption detection technique used for the detection of single gold nanoparticles (NPs), which can be a valuable tool to tackle complex cellular activities. In order to study the dynamics of individual proteins in confined regions such as in neural synapses or in cell adhesion sites, small nanoprobes are needed. Gold NPs (~ 5 nm) can be used, however their surface plasmon resonance (SPR) is centered at 530 nm, a spectral domain where absorption of cellular organelles results in a background signal, which limits the sensitivity of PhI. A brilliant way to find the needle in the haystack is the development of a novel nanoprobe having NIR-absorption, smaller size and high specificity. In “TiFuN”, we will achieve this goal by developing tiny (length/diameter <10 nm/5 nm) gold nanorods (T-rods), an elongated gold NP with tunable SPR in the NIR-window. Different aspect ratio T-rods harvested using Density Gradient Ultrahigh (DGU) centrifugation protocol will be highly promising probes for multicolor labeling and detection of proteins. A dedicated PhI setup based on NIR-laser sources will also be built. Subsequently, the bioconjuagted T-rods and NIR-PhI will be used to study the dynamics of neurotransmitter receptors in synapse and integrin proteins in cell adhesion sites owing to their small core volume, NIR-absorption, exceptional photostability, and non-toxicity. Bioconjugated T-rods will also display the unique property of being easily detected with light and electron microscopy at the single- molecule level, and therefore will be a valuable tool for light/electron correlative microscopy. This highly interdisciplinary project (optics, chemistry and biology) will utilize the fellow’s expertise in nanochemistry in combination with world-leading expertise of Prof. Lounis group in single-molecule detection and Dr. Choquet institute in neuroscience and cell biology.


year authors and title journal last update
List of publications.
2017 Edakkattuparambil Sidharth Shibu, Nadezda Varkentina, Laurent Cognet, Brahim Lounis
Small Gold Nanorods with Tunable Absorption for Photothermal Microscopy in Cells
published pages: 1600280, ISSN: 2198-3844, DOI: 10.1002/advs.201600280
Advanced Science 4/2 2019-07-23

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The information about "TIFUN" are provided by the European Opendata Portal: CORDIS opendata.

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