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RAGES TERMINATED

Molecular determination of Rif1-Associated Genomic Elements and their function in regulating genome activity and integrity

Total Cost €

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EC-Contrib. €

0

Partnership

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 RAGES project word cloud

Explore the words cloud of the RAGES project. It provides you a very rough idea of what is the project "RAGES" about.

mutations    lines    damage    raises    primary    genomic    me    protein    outcome    differentially    potentially    outcomes    preliminary    repair    influences    repression    genetic    53bp1    dna    strand    instability    sites    repressive    either    transcription    interestingly    repertoires    inability    host    reader    counteract    possibility    mediates    hypothesis    regulatory    examine    transcriptional    cooperate    dependent    misregulation    oncogenic    metabolised    alter    certain    cell    disease    function    cellular    landscape    reagents    regulator    drives    accurately    regulates    prevent    recruited    breaks    repaired    basis    mechanisms    usually    little    carcinogenesis    events    suggests    govern    germline    immune    decisions    paramount    seek    immunodeficiency    regulate    manner    laboratory    array    recombination    contexts    mediate    toxic    fascinating    dsbs    opportunity    critical    proteins    gene    molecular    drive    dsb    double    intermediates    chromatin    diversity    rif1    create   

Project "RAGES" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.well.ox.ac.uk/research/research-groups/chapman-group
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-31   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

Map

 Project objective

DNA double-strand breaks (DSBs) are highly toxic and must usually be accurately repaired to prevent oncogenic mutations. However, DSBs also represent necessary intermediates of recombination events required to create genetic diversity in immune repertoires and the germline. These distinct cellular contexts require that DSBs are differentially metabolised to achieve the required genetic outcome. Thus a complex system has evolved to regulate DSB repair. Rif1 was recently identified as a critical regulator of DSB repair, recruited to chromatin at DSBs by the 53BP1 chromatin reader. However, little is known about how these proteins cooperate to alter the chromatin landscape at DNA damage sites, and how this influences DNA repair decisions. Understanding the molecular basis of these proteins function is paramount, as misregulation at the level of Rif1/53BP1 is known to drive disease: loss of either protein results in primary immunodeficiency, while an inability to counteract Rif1/53BP1-dependent activities during DNA repair is associated with genomic instability that drives carcinogenesis. Interestingly, recent evidence suggests that Rif1 may also mediate gene-repression in certain chromatin contexts. This raises the possibility that the manner by which Rif1 regulates transcriptional control may be similar to its role in DNA repair. In this proposal, I seek to test my hypothesis that Rif1 mediates repressive chromatin states to regulate both transcription and DNA repair outcomes. My preliminary work and an array of unique cell lines and molecular reagents developed by my host laboratory, provide me with a unique and timely opportunity to examine this fascinating protein, and develop a better understanding of potentially common regulatory mechanisms that govern transcription and DNA repair.

 Publications

year authors and title journal last update
List of publications.
2016 Raquel Cuella-Martin, Catarina Oliveira, Helen E. Lockstone, Suzanne Snellenberg, Natalia Grolmusova, J. Ross Chapman
53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms
published pages: 51-64, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.08.002
Molecular Cell 64/1 2019-04-18

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