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MagProtoCell

Magnetic micromachines based on protocell design and engineering

Total Cost €

0

EC-Contrib. €

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Partnership

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 Outcomes and results

 MagProtoCell project word cloud

Explore the words cloud of the MagProtoCell project. It provides you a very rough idea of what is the project "MagProtoCell" about.

remote    stimulate    employing    ways    sense    made    replication    local    selective    mfs    origin    stone    of    arco    levels    prof    cellular    medium    metabolism    stepping    exchange    directed    functions    hosting    locations    biomimetic    inclusion    synthetic    chemotaxis    artificial    lifelike    composition    sensing    engineering    machines    guez    class    strategic    methodology    responsive    thereby    encapsulation    expertise    dr    mann    leadership    alternative    cutting    movement    environment    noncontact    magnetic    multidisciplinary    progress    couple    construction    drug    life    surrounding    disposition    earth    clinical    outcome    motility    fluidic    construct    chemicals    protocells    environments    clean    frs    edge    date    regard    concentrations    external    diagnosis    enhanced    few    forces    exhibiting    micromachines    temporal    rodr    university    materials    stimuli    group    bioreactor    iacute    last    spatial    mf    protocell    chemical    colloidal    involve    bristol    particles   

Project "MagProtoCell" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://www.bristol.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Protocells are artificial cellular systems exhibiting lifelike properties, which are proposed as a stepping-stone for understanding the origin of life on Earth. Features such as encapsulation, replication, metabolism and selective exchange of chemicals with the environment will enable their use as micromachines in a number of emerging applications (e.g., environment clean-up, clinical diagnosis, drug delivery, remote sensing, bioreactor technology). However, progress in such applications will be enhanced by the synthetic construction of protocells capable of directed movement in fluidic environments in response to external stimuli. To date, motility has been achieved only in a few cases, which involve a response to changes in chemical concentrations (chemotaxis) in the surrounding medium. However, controlling the chemical composition of the local environment is challenging, and thus alternative ways to stimulate motility are needed. In this regard, external magnetic fields (MFs) will enable high levels of control of protocell motility and spatial disposition to be achieved by employing noncontact forces. This is the aim of this proposal: to design and construct synthetic protocells able to sense and respond to external MFs. A key outcome of the work will be the development of a new class of magnetic micromachines based on protocell design and engineering. Such machines will couple MF-directed motility with the temporal and spatial delivery of advanced biomimetic functions. The key factor of the proposed methodology is the inclusion of colloidal magnetic particles at strategic locations in the protocell composition or in the external medium. Thereby, the expertise of the applicant (Dr. Rodríguez Arco) in the field of MF-responsive materials will be applied to the multidisciplinary and cutting-edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof. Mann FRS) has made great progress in the last few years.

 Publications

year authors and title journal last update
List of publications.
2017 Laura Rodriguez-Arco, Mei Li, Stephen Mann
Phagocytosis-inspired behaviour in synthetic protocell communities of compartmentalized colloidal objects
published pages: TBC, ISSN: 1476-1122, DOI: 10.1038/nmat4916 		Nature Materials TBC 2019-07-22

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The information about "MAGPROTOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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