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Division of labour and the origin of multicellularity

Total Cost €


EC-Contrib. €






Project "MULTICELL" data sheet

The following table provides information about the project.


Organization address
city: KIEL
postcode: 24118

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2019-08-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Understanding the evolution of multicellularity and cellular differentiation/ complexity is one of the greatest challenges in biology. Of particular interest is to determine the evolutionary processes (selective causes) and mechanisms underlying the evolutionary transition from single cells to multicellular organisms.

This project will use cyanobacteria as a model system to determine whether cellular differentiation is a cause or consequence of multicellularity. A novel theory will be tested, which predicts that the division of labour/ differentiation among cells drives the transition to a multicellular state. This will be contrasted with the classical view, where cellular specialization originates only at a much later state during the transition. The proposed project will adopt an interdisciplinary approach by combining experimental evolution (WP1) with phylogenomics (WP2). More specifically, populations of unicellular cyanobacteria will be subjected to long-term experimental evolution under two different regimes that favour either the specialization of cells into performing different physiologically incompatible processes, or the formation of non-differentiated aggregates (WP1). By linking the phenotype to the underlying genotype and to gene expression patterns, the critical steps for the transition to multicellularity will be established at the genome level. This evolutionary sequence will be directly compared to the one inferred from the cyanobacterial phylogeny (WP2). Here, whole genomes will be used to reconstruct the gain and loss events for the main ‘multicellular traits’, such as filament formation and cellular differentiation.

The findings will not only provide insight into the key events during the transition to multicellularity but will also be the first study that directly relates a transition that was achieved under artificial conditions in the laboratory to one that actually happened more than 3 billion years ago in this phylum.


year authors and title journal last update
List of publications.
2017 Robin Koch, Anne Kupczok, Karina Stucken, Judith Ilhan, Katrin Hammerschmidt, Tal Dagan
Plasticity first: molecular signatures of a complex morphological trait in filamentous cyanobacteria
published pages: , ISSN: 1471-2148, DOI: 10.1186/s12862-017-1053-5
BMC Evolutionary Biology 17/1 2020-02-06
2017 Oliver Otti, Peter Deines, Katrin Hammerschmidt, Klaus Reinhardt
Regular Wounding in a Natural System: Bacteria Associated With Reproductive Organs of Bedbugs and Their Quorum Sensing Abilities
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01855
Frontiers in Immunology 8 2020-02-06

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The information about "MULTICELL" are provided by the European Opendata Portal: CORDIS opendata.

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