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AstroSignals

Spatiotemporal dynamics of subcellular energy metabolism in astrocytes

Total Cost €

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EC-Contrib. €

0

Partnership

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 AstroSignals project word cloud

Explore the words cloud of the AstroSignals project. It provides you a very rough idea of what is the project "AstroSignals" about.

intracellular    tirf    microdomains    ca2    link    regulation    cultured    initial    local    provision    fluorescence    unknown    meet    cell    rapid    techniques    opening    compartmentalization    organization    significance    surface    biosensors    treatments    diseases    confocal    metabolic    total    phosphate    cellular    contains    glucose    transporter    momentum    astrocytic    hypotheses    microscopy    emerged    receptors    requiring    sources    signal    subcellular    sensors    astrocytes    locations    suggest    lumen    phosphatase    pool    functional    er    beta    genetically    transfer    sirna    pools    architecture    cytosolic    function    knockdown    possibilities    reflection    expertise    energy    gaining    source    combining    metabolism    immunocytochemistry    transduction    signals    energetic    reservoir    generate    luminal    contributes    internal    transported    spatiotemporal    employ    brain    optical    pase    atp    spatial    energetically    encoded    networks    human    signalling   

Project "AstroSignals" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.phar.cam.ac.uk/research/taylor/people
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

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 Project objective

The functional significance of subcellular compartmentalization in signal transduction has emerged in recent years, a development that is gaining momentum due to significant advances in optical microscopy and genetically encoded biosensors. However, much less attention has been given to the spatial architecture of the metabolic networks that provide energetic support for intracellular processes. This project will investigate spatiotemporal organization of energy metabolism in astrocytes, focusing on two hypotheses: • I propose that within astrocytes, signalling microdomains are energetically supported by local delivery of ATP. I will employ confocal and total internal reflection fluorescence (TIRF) microscopy, using biosensors for ATP, glucose and Ca2 that can be targeted to subcellular locations. My initial focus is on cultured human astrocytes and the provision of ATP for Ca2 signalling. Do the five cellular sources of astrocytic ATP support different ATP pools? Which pools are needed for the many ATP-requiring steps that link cell-surface receptors to Ca2 signals? • I suggest that the ER lumen may provide a glucose reservoir that allows rapid intracellular transfer of glucose to meet local energy needs. The ER of astrocytes contains luminal glucose-6-phosphatase-β (G-6-Pase-β) and a glucose-6-phosphate transporter, which together can generate an ER luminal pool of glucose. The source of glucose-6-phosphate transported into the ER and the function of luminal glucose are unknown. Using cytosolic and ER-targeted glucose sensors, immunocytochemistry and siRNA knockdown of glucose G-6-Pase-β, I will determine the source of the glucose pool and whether it contributes to metabolic support of Ca2 signals. Combining state-of-the-art techniques and expertise in the fields of cell signalling and metabolism, this project will enhance our understanding of metabolic regulation of signal transduction, opening new possibilities for targeted treatments of brain diseases.

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