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AstroSignals

Spatiotemporal dynamics of subcellular energy metabolism in astrocytes

Total Cost €

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EC-Contrib. €

0

Partnership

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 AstroSignals project word cloud

Explore the words cloud of the AstroSignals project. It provides you a very rough idea of what is the project "AstroSignals" about.

source    hypotheses    energetically    metabolism    cellular    cultured    suggest    contributes    pool    subcellular    generate    ca2    gaining    sensors    immunocytochemistry    astrocytic    receptors    transfer    beta    contains    techniques    brain    treatments    signal    function    total    human    transporter    local    reservoir    lumen    emerged    metabolic    microscopy    compartmentalization    energetic    possibilities    confocal    atp    glucose    diseases    internal    energy    locations    meet    genetically    astrocytes    phosphate    signalling    tirf    signals    intracellular    sources    transduction    unknown    opening    rapid    cell    significance    transported    link    organization    er    surface    requiring    biosensors    optical    reflection    microdomains    luminal    initial    provision    regulation    pase    phosphatase    pools    fluorescence    networks    spatial    employ    combining    encoded    cytosolic    sirna    knockdown    architecture    functional    momentum    expertise    spatiotemporal   

Project "AstroSignals" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.phar.cam.ac.uk/research/taylor/people
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

The functional significance of subcellular compartmentalization in signal transduction has emerged in recent years, a development that is gaining momentum due to significant advances in optical microscopy and genetically encoded biosensors. However, much less attention has been given to the spatial architecture of the metabolic networks that provide energetic support for intracellular processes. This project will investigate spatiotemporal organization of energy metabolism in astrocytes, focusing on two hypotheses: • I propose that within astrocytes, signalling microdomains are energetically supported by local delivery of ATP. I will employ confocal and total internal reflection fluorescence (TIRF) microscopy, using biosensors for ATP, glucose and Ca2 that can be targeted to subcellular locations. My initial focus is on cultured human astrocytes and the provision of ATP for Ca2 signalling. Do the five cellular sources of astrocytic ATP support different ATP pools? Which pools are needed for the many ATP-requiring steps that link cell-surface receptors to Ca2 signals? • I suggest that the ER lumen may provide a glucose reservoir that allows rapid intracellular transfer of glucose to meet local energy needs. The ER of astrocytes contains luminal glucose-6-phosphatase-β (G-6-Pase-β) and a glucose-6-phosphate transporter, which together can generate an ER luminal pool of glucose. The source of glucose-6-phosphate transported into the ER and the function of luminal glucose are unknown. Using cytosolic and ER-targeted glucose sensors, immunocytochemistry and siRNA knockdown of glucose G-6-Pase-β, I will determine the source of the glucose pool and whether it contributes to metabolic support of Ca2 signals. Combining state-of-the-art techniques and expertise in the fields of cell signalling and metabolism, this project will enhance our understanding of metabolic regulation of signal transduction, opening new possibilities for targeted treatments of brain diseases.

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