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MaSCheNav

Mass Spectrometry-Based Chemoproteomic Profiling of Nav1.7, a Voltage-Gated Sodium Channel

Total Cost €

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EC-Contrib. €

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Partnership

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 MaSCheNav project word cloud

Explore the words cloud of the MaSCheNav project. It provides you a very rough idea of what is the project "MaSCheNav" about.

propagation    complexes    once    otherwise    action    gene    function    transmembrane    thereby    fundamental    chemical    potentials    modulators    suffering    validated    lacking    labeling    flux    lines    designed    peptide    excitable    pain    chronic    conjugation    sensing    syndrome    expressed    signal    cellular    dramatically    perfectly    cells    perceive    extreme    tools    vgsc    nine    protein    probe    derives    isolate    linked    sodium    remarkably    disease    paving    nociceptive    photoaffinity    peripheral    selective    types    model    na    nav    channels    inhibitors    membrane    spectrometry    patients    encoding    interaction    congenital    voltage    tandem    subtypes    binding    expressing    nav1    mass    medical    vgscs    patient    bioorthogonal    stimuli    ions    events    chemoproteomics    cell    nervous    solid    treatments    mutations    pharmacological    ligand    neurons    unmet    functional    subtype    channel    generation    translate    attainment    synthesis    indifference    structural    healthy    safe    painful    gated    transmission   

Project "MaSCheNav" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

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 Project objective

Chronic pain represents a major unmet medical need which has been linked to changes in voltage-gated sodium channels (VGSCs). These channels are transmembrane protein-complexes with a key-role in signal transmission in excitable cells, such as neurons, and allow the flux of Na ions through the cellular membrane in response to specific stimuli, thus controlling the generation and propagation of action potentials. Nine VGSC subtypes are known to be expressed in different cell types, and among them subtype Nav1.7 is of extreme interest since it is involved in nociceptive processing (pain-sensing) in the peripheral nervous system. Remarkably, patients suffering from congenital indifference to pain syndrome, which derives from loss-of-function mutations of the gene encoding for Nav1.7, have a dramatically reduced ability to perceive painful stimuli, but are otherwise perfectly healthy. Therefore, Nav1.7 has been recognized as an exciting target for pharmacological treatments of pain. However, detailed structural and functional information is lacking, and its attainment represents a fundamental step in the challenging task of finding Nav subtype-selective modulators. Thus, the main focus of my project is to study ligand-binding events with known modulators, thereby paving the way to the design of safe and selective inhibitors. I will develop, by solid phase peptide synthesis, a chemical probe specifically designed to isolate Nav1.7, using a tandem photoaffinity labeling-bioorthogonal conjugation approach. This probe will be applied in model cell lines expressing the channel, in order to study their binding interaction through mass spectrometry-based chemoproteomics. Once these chemical tools are established and validated in the model system, I will translate them to patient-derived cells, in order to study disease-relevant systems.

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The information about "MASCHENAV" are provided by the European Opendata Portal: CORDIS opendata.

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