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Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing

Total Cost €


EC-Contrib. €






 VascColl project word cloud

Explore the words cloud of the VascColl project. It provides you a very rough idea of what is the project "VascColl" about.

bioagent    macrophage    tools    prepared    escalating    royal    faculty    stimulating    scaffold    am    delay    chronic    trigger    graduate    amputation    collagen    reporting    planning    expert    rcsi    avail    usa    fergal    consequence    hope    me    synchronicity    teach    epidemic    prof    active    maturation    vascular    returned    requisite    scientific    polarisation    supervision    grant    colleagues    devastating    harvard    having    backed    lab    filing    vascularisation    diabetic    bioagents    complementary    group    staff    surgeons    secondment    ultrasound    university    tackle    msca    successfully    input    positive    niche    skillsets    temporally    diabetes    postdoctoral    works    supervise    recruit    limb    college    patent    continue    equipping    run    reintegration    skills    drug    commercialisation    successful    financial    students    lack    fellow    ulcers    brien    foot    additional    training    attain    independent    massachusetts    healing    ireland    wound    dfus    explored    integrate    academic   

Project "VascColl" data sheet

The following table provides information about the project.


Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Having recently returned to the EU following Graduate (Massachusetts Institute of Technology) and Postdoctoral Training (Harvard University) in the USA, I hope to work as a MSCA Reintegration Fellow to tackle a devastating element of the escalating epidemic of diabetes. Specifically, the lack of synchronicity in diabetic wound-healing can lead to chronic diabetic foot ulcers (DFUs), with limb amputation being the devastating consequence in many cases. Thus, the scientific goal of this proposal is to integrate my tools for temporally-controlled drug delivery with the existing collagen-based scaffold developed in Prof. Fergal O’Brien’s group at the Royal College of Surgeons in Ireland (RCSI). The proposed novel scaffold will be used to deliver vascular bioagents to DFUs, with ultrasound used as a trigger to delay the delivery of a vascular maturation bioagent. The target is to improve healing by stimulating vascularisation. The additional positive effects the bioagents may have on macrophage polarisation will be explored during a planned secondment. The training objective of this grant is to attain the requisite scientific and complementary skills so that I am fully prepared to run a research lab and teach in a top academic institution. This will be achieved through the expert supervision and input of Prof. O’Brien – and during a planned secondment – and will be backed up by colleagues in the lab and RCSI’s staff training activities. In addition, by managing the project, I will further develop skills relating to project planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also continue to avail of opportunities to teach and to recruit and supervise students on this project or related works. If successful, this grant will help me establish an independent research niche in active and emerging research fields, while equipping me with the requisite skillsets to successfully work as an independent faculty member.


year authors and title journal last update
List of publications.
2016 Cathal J. Kearney, Abhay Pandit
Special Collection: Closing the Gaps in Skin Wound Healing
published pages: 401-402, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2015.0549
Tissue Engineering Part A 22/5-6 2019-07-24
2017 Darina A. Gilroy, Chris Hobbs, Valeria Nicolosi, Conor T. Buckley, Fergal J. O\'Brien, Cathal J. Kearney
Development of magnetically active scaffolds as intrinsically-deformable bioreactors
published pages: 1-8, ISSN: 2159-6859, DOI: 10.1557/mrc.2017.41
MRS Communications 2019-07-24
2016 Stephen Kennedy, Jennifer Hu, Cathal Kearney, Hadas Skaat, Luo Gu, Marco Gentili, Herman Vandenburgh, David Mooney
Sequential release of nanoparticle payloads from ultrasonically burstable capsules
published pages: 91-101, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.10.008
Biomaterials 75 2019-07-24
2016 Cathal J. Kearney, Christopher R. Lucas, Fergal J. O\'Brien, Carlos E. Castro
DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior
published pages: 5509-5524, ISSN: 0935-9648, DOI: 10.1002/adma.201504733
Advanced Materials 28/27 2019-07-24

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The information about "VASCCOLL" are provided by the European Opendata Portal: CORDIS opendata.

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