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Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing

Total Cost €


EC-Contrib. €






 VascColl project word cloud

Explore the words cloud of the VascColl project. It provides you a very rough idea of what is the project "VascColl" about.

teach    works    stimulating    polarisation    recruit    reporting    rcsi    tackle    msca    scientific    training    colleagues    trigger    graduate    fergal    limb    consequence    run    collagen    patent    positive    diabetes    harvard    integrate    diabetic    postdoctoral    chronic    students    synchronicity    ulcers    temporally    secondment    expert    hope    dfus    continue    supervise    successful    additional    massachusetts    drug    healing    skills    foot    lack    scaffold    devastating    staff    royal    ireland    bioagent    supervision    prof    commercialisation    grant    requisite    reintegration    returned    filing    group    epidemic    input    college    prepared    wound    vascular    university    am    complementary    skillsets    successfully    vascularisation    amputation    backed    equipping    planning    tools    independent    brien    attain    financial    ultrasound    explored    surgeons    having    active    delay    faculty    escalating    niche    me    fellow    lab    maturation    academic    avail    macrophage    bioagents    usa   

Project "VascColl" data sheet

The following table provides information about the project.


Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Having recently returned to the EU following Graduate (Massachusetts Institute of Technology) and Postdoctoral Training (Harvard University) in the USA, I hope to work as a MSCA Reintegration Fellow to tackle a devastating element of the escalating epidemic of diabetes. Specifically, the lack of synchronicity in diabetic wound-healing can lead to chronic diabetic foot ulcers (DFUs), with limb amputation being the devastating consequence in many cases. Thus, the scientific goal of this proposal is to integrate my tools for temporally-controlled drug delivery with the existing collagen-based scaffold developed in Prof. Fergal O’Brien’s group at the Royal College of Surgeons in Ireland (RCSI). The proposed novel scaffold will be used to deliver vascular bioagents to DFUs, with ultrasound used as a trigger to delay the delivery of a vascular maturation bioagent. The target is to improve healing by stimulating vascularisation. The additional positive effects the bioagents may have on macrophage polarisation will be explored during a planned secondment. The training objective of this grant is to attain the requisite scientific and complementary skills so that I am fully prepared to run a research lab and teach in a top academic institution. This will be achieved through the expert supervision and input of Prof. O’Brien – and during a planned secondment – and will be backed up by colleagues in the lab and RCSI’s staff training activities. In addition, by managing the project, I will further develop skills relating to project planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also continue to avail of opportunities to teach and to recruit and supervise students on this project or related works. If successful, this grant will help me establish an independent research niche in active and emerging research fields, while equipping me with the requisite skillsets to successfully work as an independent faculty member.


year authors and title journal last update
List of publications.
2016 Cathal J. Kearney, Abhay Pandit
Special Collection: Closing the Gaps in Skin Wound Healing
published pages: 401-402, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2015.0549
Tissue Engineering Part A 22/5-6 2019-07-24
2017 Darina A. Gilroy, Chris Hobbs, Valeria Nicolosi, Conor T. Buckley, Fergal J. O\'Brien, Cathal J. Kearney
Development of magnetically active scaffolds as intrinsically-deformable bioreactors
published pages: 1-8, ISSN: 2159-6859, DOI: 10.1557/mrc.2017.41
MRS Communications 2019-07-24
2016 Stephen Kennedy, Jennifer Hu, Cathal Kearney, Hadas Skaat, Luo Gu, Marco Gentili, Herman Vandenburgh, David Mooney
Sequential release of nanoparticle payloads from ultrasonically burstable capsules
published pages: 91-101, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.10.008
Biomaterials 75 2019-07-24
2016 Cathal J. Kearney, Christopher R. Lucas, Fergal J. O\'Brien, Carlos E. Castro
DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior
published pages: 5509-5524, ISSN: 0935-9648, DOI: 10.1002/adma.201504733
Advanced Materials 28/27 2019-07-24

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The information about "VASCCOLL" are provided by the European Opendata Portal: CORDIS opendata.

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