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Functional brain networks in epilepsy

Total Cost €


EC-Contrib. €






Project "EPICONNECT" data sheet

The following table provides information about the project.


Organization address
city: GENT
postcode: 9000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website
 Total cost 211˙964 €
 EC max contribution 211˙964 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2018-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 211˙964.00


 Project objective

This proposal for a Marie Sklodowska-Curie Global Fellowship is meant for the training of Dr. Pieter van Mierlo, currently at Ghent University, in the Functional Brain Mapping Laboratory (FBM Lab) of the University of Geneva, one of the world leading brain imaging laboratories. The goal of the project is to explore the communication between brain regions in epilepsy patients to ameliorate their treatment. In the first stage a non-invasive tool, ElectroEncephaloGraphy (EEG), will be used to measure the electric field of the brain through electrodes placed on top of the scalp. By measuring the voltage difference between the EEG electrodes the electric field of the brain can be studied with a high temporal resolution (ms). Recently, high density EEG (hd-EEG) systems have been developed with up to 256 electrodes. These systems allow more accurate measurements compared to the old systems having only ± 32 electrodes. The FBM Lab is one of the few labs that have hd-EEG recordings of epilepsy patients. In this project we will develop an algorithm to investigate the brain networks in epilepsy patients based on hd-EEG recordings. The brain networks will be studied to localize the epileptic focus, the brain region that causes the seizures. In the second stage hd-EEG will be combined with functional Magnetic Resonance Imaging (fMRI) that images the concentration of oxygen in the brain with a high spatial resolution (mm). The simultaneously recorded hd-EEG / fMRI allows studying the brain networks with both a high temporal and spatial resolution. Furthermore, fMRI is more sensitive to record brain activity of deep brain structures compared to hd-EEG. The added value of combining hd-EEG with fMRI to localize the epileptic focus will be assessed. In the third and final stage, the developed algorithms will be implemented at the UGent. A prospective study will be done to quantify the influence of functional connectivity analysis on patients’ treatment management.


year authors and title journal last update
List of publications.
2018 Thibault Verhoeven, Ana Coito, Gijs Plomp, Aljoscha Thomschewski, Francesca Pittau, Eugen Trinka, Roland Wiest, Karl Schaller, Christoph Michel, Margitta Seeck, Joni Dambre, Serge Vulliemoz, Pieter van Mierlo
Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes
published pages: 10-15, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2017.09.021
NeuroImage: Clinical 17 2020-02-24
2017 Pieter van Mierlo, Gregor Strobbe, Vincent Keereman, Gwénael Birot, Stefanie Gadeyne, Markus Gschwind, Evelien Carrette, Alfred Meurs, Dirk Van Roost, Kristl Vonck, Margitta Seeck, Serge Vulliémoz, Paul Boon
Automated long-term EEG analysis to localize the epileptogenic zone
published pages: 322-333, ISSN: 2470-9239, DOI: 10.1002/epi4.12066
Epilepsia Open 2/3 2020-02-24
2018 Pieter van Mierlo, Octavian Lie, Willeke Staljanssens, Ana Coito, Serge Vulliémoz
Influence of Time-Series Normalization, Number of Nodes, Connectivity and Graph Measure Selection on Seizure-Onset Zone Localization from Intracranial EEG
published pages: , ISSN: 0896-0267, DOI: 10.1007/s10548-018-0646-7
Brain Topography 2020-02-24
2017 Octavian V. Lie, Pieter van Mierlo
Seizure-Onset Mapping Based on Time-Variant Multivariate Functional Connectivity Analysis of High-Dimensional Intracranial EEG: A Kalman Filter Approach
published pages: 46-59, ISSN: 0896-0267, DOI: 10.1007/s10548-016-0527-x
Brain Topography 30/1 2020-02-24
2017 Willeke Staljanssens, Gregor Strobbe, Roel Van Holen, Gwénaël Birot, Markus Gschwind, Margitta Seeck, Stefaan Vandenberghe, Serge Vulliémoz, Pieter van Mierlo
Seizure Onset Zone Localization from Ictal High-Density EEG in Refractory Focal Epilepsy
published pages: 257-271, ISSN: 0896-0267, DOI: 10.1007/s10548-016-0537-8
Brain Topography 30/2 2020-02-24
2016 Markus Gschwind, Pieter van Mierlo
Difficulty of Comparing the Multiple Heterogeneous Approaches: Comment to Transcranial Direct Current Stimulation in Epilepsy
published pages: 459-461, ISSN: 1935-861X, DOI: 10.1016/j.brs.2016.03.003
Brain Stimulation 9/3 2020-02-24
2016 Ana Coito, Christoph M. Michel, Pieter van Mierlo, Serge Vulliemoz, Gijs Plomp
Directed Functional Brain Connectivity Based on EEG Source Imaging: Methodology and Application to Temporal Lobe Epilepsy
published pages: 2619-2628, ISSN: 0018-9294, DOI: 10.1109/TBME.2016.2619665
IEEE Transactions on Biomedical Engineering 63/12 2020-02-24
2017 Willeke Staljanssens, Gregor Strobbe, Roel Van Holen, Vincent Keereman, Stefanie Gadeyne, Evelien Carrette, Alfred Meurs, Francesca Pittau, Shahan Momjian, Margitta Seeck, Paul Boon, Stefaan Vandenberghe, Serge Vulliemoz, Kristl Vonck, Pieter van Mierlo
EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy
published pages: 689-698, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2017.09.011
NeuroImage: Clinical 16 2020-02-24

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